Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate
Ito, Sumito, Lee, Wooin, Park, Ji Eun, Yasunaga, Masa, Mori, Ayano, Ohtsuki, Sumio, Sugiyama, Yuichi
Published in Journal of pharmaceutical sciences (01.01.2021)
Published in Journal of pharmaceutical sciences (01.01.2021)
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Journal Article
Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney
Kito, Tomoko, Ito, Sumito, Mizuno, Tadahaya, Maeda, Kazuya, Kusuhara, Hiroyuki
Published in Drug metabolism and pharmacokinetics (01.02.2019)
Published in Drug metabolism and pharmacokinetics (01.02.2019)
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Journal Article
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine
Ito, Sumito, Kusuhara, Hiroyuki, Kuroiwa, Yushun, Wu, Chunyong, Moriyama, Yoshinori, Inoue, Katsuhisa, Kondo, Tsunenori, Yuasa, Hiroaki, Nakayama, Hideki, Horita, Shigeru, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
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Journal Article
Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins
Kato, Koji, Mori, Haruyuki, Kito, Tomoko, Yokochi, Miyu, Ito, Sumito, Inoue, Katsuhisa, Yonezawa, Atsushi, Katsura, Toshiya, Kumagai, Yuji, Yuasa, Hiroaki, Moriyama, Yoshinori, Inui, Ken-ichi, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in Pharmaceutical research (01.01.2014)
Published in Pharmaceutical research (01.01.2014)
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Journal Article
Possible Role of Organic Cation Transporters in the Distribution of [ 11 C]Sulpiride, a Dopamine D 2 Receptor Antagonist
Takano, Harumasa, Ito, Sumito, Zhang, Xuan, Ito, Hiroshi, Zhang, Ming-Rong, Suzuki, Hiroshi, Maeda, Kazuya, Kusuhara, Hiroyuki, Suhara, Tetsuya, Sugiyama, Yuichi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Journal Article
Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration
Liu, Houfu, Yu, Na, Lu, Sijie, Ito, Sumito, Zhang, Xuan, Prasad, Bhagwat, He, Enuo, Lu, Xinyan, Li, Yang, Wang, Fei, Xu, Han, An, Gang, Unadkat, Jashvant D, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Sahi, Jasminder
Published in Drug metabolism and disposition (01.07.2015)
Published in Drug metabolism and disposition (01.07.2015)
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Journal Article
Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction
Takayama, Kazuo, Negoro, Ryosuke, Yamashita, Tomoki, Kawai, Kanae, Ichikawa, Moe, Mori, Takanori, Nakatsu, Noriyuki, Harada, Kazuo, Ito, Sumito, Yamada, Hiroshi, Yamaura, Yoshiyuki, Hirata, Kazumasa, Ishida, Seiichi, Mizuguchi, Hiroyuki
Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
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Journal Article
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
Ito, Sumito, Kusuhara, Hiroyuki, Yokochi, Miyu, Toyoshima, Junko, Inoue, Katsuhisa, Yuasa, Hiroaki, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
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Journal Article
Relationship Between the Urinary Excretion Mechanisms of Drugs and Their Physicochemical Properties
Ito, Sumito, Ando, Hirotaka, Ose, Atsushi, Kitamura, Yoshiaki, Ando, Tomohiro, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in Journal of pharmaceutical sciences (01.09.2013)
Published in Journal of pharmaceutical sciences (01.09.2013)
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Journal Article
Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist
Takano, Harumasa, Ito, Sumito, Zhang, Xuan, Ito, Hiroshi, Zhang, Ming-Rong, Suzuki, Hiroshi, Maeda, Kazuya, Kusuhara, Hiroyuki, Suhara, Tetsuya, Sugiyama, Yuichi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Journal Article
Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals
Kato, Koji, Kusuhara, Hiroyuki, Kumagai, Yuji, Ieiri, Ichiro, Mori, Haruyuki, Ito, Sumito, Nakai, Yasuhiro, Maeda, Kazuya, Sugiyama, Yuichi
Published in Pharmacogenetics and genomics (01.05.2012)
Published in Pharmacogenetics and genomics (01.05.2012)
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Journal Article
The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function
Higashikuni, Yasutomi, Sainz, Julie, Nakamura, Kazuto, Takaoka, Minoru, Enomoto, Soichiro, Iwata, Hiroshi, Sahara, Makoto, Tanaka, Kimie, Koibuchi, Nobutaka, Ito, Sumito, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Hirata, Yasunobu, Nagai, Ryozo, Sata, Masataka
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2010)
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Journal Article
Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: Therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development
Takahara, Noriko, Saga, Tsuneo, Inubushi, Masayuki, Kusuhara, Hiroyuki, Seki, Chie, Ito, Sumito, Oyama, Nobuyuki, Yokoyama, Osamu, Sugiyama, Yuichi, Fujibayashi, Yasuhisa
Published in Nuclear medicine and biology (01.07.2013)
Published in Nuclear medicine and biology (01.07.2013)
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Journal Article
Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 TransductionSummary
Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi
Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
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Published in Cellular and molecular gastroenterology and hepatology (01.01.2019)
Journal Article
Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban
Tsuruya, Yuri, Nakanishi, Takeo, Komori, Hisakazu, Wang, Xinying, Ishiguro, Naoki, Kito, Tomoko, Ikukawa, Kouji, Kishimoto, Wataru, Ito, Sumito, Schaefer, Olaf, Ebner, Thomas, Yamamura, Norio, Kusuhara, Hiroyuki, Tamai, Ikumi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Journal Article
Evaluation of [11C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection
Seki, Chie, Oh-Nishi, Arata, Nagai, Yuji, Minamimoto, Takafumi, Obayashi, Shigeru, Higuchi, Makoto, Takei, Makoto, Furutsuka, Kenji, Ito, Takehito, Zhang, Ming-Rong, Ito, Hiroshi, Ito, Mototsugu, Ito, Sumito, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Suhara, Tetsuya
Published in EJNMMI research (02.07.2014)
Published in EJNMMI research (02.07.2014)
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