Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT
Nishimura, Takashi, Mitsunaga, Makoto, Ito, Kimihiro, Kobayashi, Hisataka, Saruta, Masayuki
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.01.2020)
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.01.2020)
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Journal Article
Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody–Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer
Ito, Kimihiro, Mitsunaga, Makoto, Nishimura, Takashi, Saruta, Masayuki, Iwamoto, Takeo, Kobayashi, Hisataka, Tajiri, Hisao
Published in Bioconjugate chemistry (17.05.2017)
Published in Bioconjugate chemistry (17.05.2017)
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Journal Article
Acquired resistance to trastuzumab/pertuzumab or to T‐DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728
Irie, Hiroki, Kawabata, Rumi, Fujioka, Yayoi, Nakagawa, Fumio, Itadani, Hiraku, Nagase, Hideki, Ito, Kimihiro, Uchida, Junji, Ohkubo, Shuichi, Matsuo, Kenichi
Published in Cancer science (01.06.2020)
Published in Cancer science (01.06.2020)
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Journal Article
TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways
Miura, Akihiro, Sootome, Hiroshi, Fujita, Naoya, Suzuki, Takamasa, Fukushima, Hiroto, Mizuarai, Shinji, Masuko, Norio, Ito, Kimihiro, Hashimoto, Akihiro, Uto, Yoshihiro, Sugimoto, Tetsuya, Takahashi, Hidekazu, Mitsuya, Morihiro, Hirai, Hiroshi
Published in Investigational new drugs (01.06.2021)
Published in Investigational new drugs (01.06.2021)
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Journal Article
TAS-121, A Selective Mutant EGFR Inhibitor, Shows Activity Against Tumors Expressing Various EGFR Mutations Including T790M and Uncommon Mutations G719X
Ito, Kimihiro, Nishio, Makoto, Kato, Masanori, Murakami, Haruyasu, Aoyagi, Yoshimi, Ohe, Yuichiro, Okayama, Takashige, Hashimoto, Akihiro, Ohsawa, Hirokazu, Tanaka, Gotaro, Nonoshita, Katsumasa, Ito, Satoru, Matsuo, Kenichi, Miyadera, Kazutaka
Published in Molecular cancer therapeutics (01.05.2019)
Published in Molecular cancer therapeutics (01.05.2019)
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Journal Article
Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens
Mitsunaga, Makoto, Ito, Kimihiro, Nishimura, Takashi, Miyata, Hironori, Miyakawa, Kei, Morita, Takeshi, Ryo, Akihide, Kobayashi, Hisataka, Mizunoe, Yoshimitsu, Iwase, Tadayuki
Published in Communications biology (04.07.2022)
Published in Communications biology (04.07.2022)
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Journal Article
Abstract 3600: The prominent safety profile of TAS-115, a novel c-Met + VEGFR dual kinase inhibitor can lead to potentiate the efficacy via durable inhibition of angiogenesis
Ochiiwa, Hiroaki, Fujita, Hidenori, Ito, Kimihiro, Takenaka, Toru, Huang, Jinhong, Ito, Satoko, Suzuki, Takamasa, Egami, Kousuke, Suefuji, Takashi, Sato, Ayako, Sato, Tsudoi, Fujioka, Yayoi, Kato, Masanori, Aoyagi, Yoshimi, Hashimoto, Akihiro, Kazuno, Hideki, Miyadera, Kazutaka, Suda, Yoshimitsu, Yonekura, Kazuhiko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
L-Type Fatty Acid Binding Protein Transgenic Mouse as a Novel Tool to Explore Cytotoxicity to Renal Proximal Tubules
Nakamura, Kazuo, Ito, Kimihiro, Kato, Yukio, Sugaya, Takeshi, Kubo, Yoshiyuki, Tsuji, Akira
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
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Journal Article
Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors
Sootome, Hiroshi, Fujita, Hidenori, Ito, Kenjiro, Ochiiwa, Hiroaki, Fujioka, Yayoi, Ito, Kimihiro, Miura, Akihiro, Sagara, Takeshi, Ito, Satoru, Ohsawa, Hirokazu, Otsuki, Sachie, Funabashi, Kaoru, Yashiro, Masakazu, Matsuo, Kenichi, Yonekura, Kazuhiko, Hirai, Hiroshi
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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Journal Article
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses
Iwase, Tadayuki, Ito, Kimihiro, Nishimura, Takashi, Miyakawa, Kei, Ryo, Akihide, Kobayashi, Hisataka, Mitsunaga, Makoto
Published in Nature protocols (01.11.2023)
Published in Nature protocols (01.11.2023)
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Journal Article
Abstract 5767: Vascular endothelial growth factor receptor 2 targeted photoimmunotherapy
Mitsunaga, Makoto, Nishimura, Takashi, Ito, Kimihiro
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Combination photoimmunotherapy with monoclonal antibodies recognizing different epitopes of human epidermal growth factor receptor 2: an assessment of phototherapeutic effect based on fluorescence molecular imaging
Ito, Kimihiro, Mitsunaga, Makoto, Nishimura, Takashi, Kobayashi, Hisataka, Tajiri, Hisao
Published in Oncotarget (22.03.2016)
Published in Oncotarget (22.03.2016)
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Journal Article
Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms
Ito, Kimihiro, Mitsunaga, Makoto, Arihiro, Seiji, Saruta, Masayuki, Matsuoka, Mika, Kobayashi, Hisataka, Tajiri, Hisao
Published in BMC cancer (25.01.2016)
Published in BMC cancer (25.01.2016)
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Journal Article
Abstract A126: Acquired resistance to trastuzumab/pertuzumab, or to T-DM1 in vivo can be overcome by HER2 inhibition with TAS0728
Irie, Hiroki, Kawabata, Rumi, Fujioka, Yayoi, Nakagawa, Fumio, Nagase, Hideki, Itadani, Hiraku, Ito, Kimihiro, Uchida, Junji, Ohkubo, Shuichi, Matsuo, Kenichi, Sagara, Takeshi, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
Irie, Hiroki, Ito, Kimihiro, Fujioka, Yayoi, Oguchi, Kei, Fujioka, Akio, Hashimoto, Akihiro, Ohsawa, Hirokazu, Tanaka, Kenji, Funabashi, Kaoru, Araki, Hikari, Kawai, Yuichi, Shimamura, Tadashi, Wadhwa, Renu, Ohkubo, Shuichi, Matsuo, Kenichi
Published in Molecular cancer therapeutics (01.04.2019)
Published in Molecular cancer therapeutics (01.04.2019)
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