Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interaction
Singh, Rajinder, Sran, Arvinder, Carroll, David C., Huang, Jianing, Tsvetkov, Lyuben, Zhou, Xiulan, Sheung, Julie, McLaughlin, John, Issakani, Sarkiz D., Payan, Donald G., Shaw, Simon J.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators
Shaw, Simon J., Goff, Dane A., Boralsky, Luke A., Singh, Rajinder, Sweeny, David J., Park, Gary, Sun, Tian-Qiang, Jenkins, Yonchu, Markovtsov, Vadim, Issakani, Sarkiz D., Payan, Donald G., Hitoshi, Yasumichi
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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Journal Article
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419
Shaw, Simon J., Goff, Dane A., Carroll, David C., Singh, Rajinder, Sweeny, David J., Park, Gary, Jenkins, Yonchu, Markovtsov, Vadim, Sun, Tian-Qiang, Issakani, Sarkiz D., Hitoshi, Yasumichi, Payan, Donald G.
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication
Huang, Peiyong, Goff, Dane A, Huang, Qi, Martinez, Anthony, Xu, Xiang, Crowder, Scott, Issakani, Sarkiz D, Anderson, Emily, Sheng, Ning, Achacoso, Philip, Yen, Ann, Kinsella, Todd, Darwish, Ihab S, Kolluri, Rao, Hong, Hui, Qu, Kunbin, Stauffer, Emily, Goldstein, Eileen, Singh, Rajinder, Payan, Donald G, Lu, H Henry
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Journal Article
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L, Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J, McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J, Xu, Xiang, Issakani, Sarkiz D, Carroll, David C, Goff, Dane A, Shaw, Simon J, Singh, Rajinder, Boros, Laszlo G, Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G, Kinsella, Todd M, Hitoshi, Yasumichi
Published in PloS one (05.12.2013)
Published in PloS one (05.12.2013)
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Journal Article
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling
Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Sylvain, Catherine, Clough, Jeffrey, Carroll, David, Keim, Holger, Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Herlaar, Ellen, Issakani, Sarkiz D., Wong, Brian R., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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Journal Article
Application of cultured human mast cells (CHMC) for the design and structure–activity relationship of IgE-mediated mast cell activation inhibitors
Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Carroll, David, Clough, Jeffrey, Keim, Holger, Sylvain, Catherine, Rossi, Alexander B., Coquilla, Christina, Issakani, Sarkiz D., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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Journal Article
Identification of the Syk kinase inhibitor R112 by a human mast cell screen
Rossi, Alexander B., Herlaar, Ellen, Braselmann, Sylvia, Huynh, Stacey, Taylor, Vanessa, Frances, Roy, Issakani, Sarkiz D., Argade, Ankush, Singh, Rajinder, Payan, Donald G., Masuda, Esteban S.
Published in Journal of Allergy and Clinical Immunology (01.09.2006)
Published in Journal of Allergy and Clinical Immunology (01.09.2006)
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Journal Article
Abstract 3021: Development of small molecule direct AMPK activators for the treatment of cancer
Hitoshi, Yasumichi, Jenkins, Yonchu, Li, Yingwu, Sampang, Elmer, Xu, Xiang, Dong, Guodong, Huang, Jianing, Lin, Nan, Goff, Dane, Shaw, Simon, Boralsky, Luke, Singh, Rajinder, Issakani, Sarkiz D., Payan, Donald G.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Identification of the SyR kinase inhibitor R112 by a human mast cell screen
ROSSI, Alexander B, HERLAAR, Ellen, MASUDA, Esteban S, BRASELMANN, Sylvia, HUYNH, Stacey, TAYLOR, Vanessa, FRANCES, Roy, ISSAKANI, Sarkiz D, ARGADE, Ankush, SINGH, Rajinder, PAYAN, Donald G
Published in Journal of allergy and clinical immunology (2006)
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Published in Journal of allergy and clinical immunology (2006)
Journal Article
Rhodanine compositions for use as antiviral agents
Singh, Rajinder, Ramesh, Usha, Issakani, Sarkiz D, Look, Gary Charles
Year of Publication 28.07.2009
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Year of Publication 28.07.2009
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