Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis
Wang, Ying-Hua, Israelsen, William J, Lee, Dongjun, Yu, Vionnie W C, Jeanson, Nathaniel T, Clish, Clary B, Cantley, Lewis C, Vander Heiden, Matthew G, Scadden, David T
Published in Cell (11.09.2014)
Published in Cell (11.09.2014)
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Journal Article
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Palsson-McDermott, Eva M., Curtis, Anne M., Goel, Gautam, Lauterbach, Mario A.R., Sheedy, Frederick J., Gleeson, Laura E., van den Bosch, Mirjam W.M., Quinn, Susan R., Domingo-Fernandez, Raquel, Johnston, Daniel G.W., Jiang, Jian-kang, Israelsen, William J., Keane, Joseph, Thomas, Craig, Clish, Clary, Vander Heiden, Matthew, Xavier, Ramnik J., O’Neill, Luke A.J.
Published in Cell metabolism (06.01.2015)
Published in Cell metabolism (06.01.2015)
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Journal Article
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
Qi, Weier, Keenan, Hillary A, Li, Qian, Ishikado, Atsushi, Kannt, Aimo, Sadowski, Thorsten, Yorek, Mark A, Wu, I-Hsien, Lockhart, Samuel, Coppey, Lawrence J, Pfenninger, Anja, Liew, Chong Wee, Qiang, Guifen, Burkart, Alison M, Hastings, Stephanie, Pober, David, Cahill, Christopher, Niewczas, Monika A, Israelsen, William J, Tinsley, Liane, Stillman, Isaac E, Amenta, Peter S, Feener, Edward P, Vander Heiden, Matthew G, Stanton, Robert C, King, George L
Published in Nature medicine (01.06.2017)
Published in Nature medicine (01.06.2017)
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Journal Article
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
Dayton, Talya L, Gocheva, Vasilena, Miller, Kathryn M, Israelsen, William J, Bhutkar, Arjun, Clish, Clary B, Davidson, Shawn M, Luengo, Alba, Bronson, Roderick T, Jacks, Tyler, Vander Heiden, Matthew G
Published in Genes & development (01.05.2016)
Published in Genes & development (01.05.2016)
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Journal Article
Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G.
Published in Molecular cell (08.01.2015)
Published in Molecular cell (08.01.2015)
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Journal Article
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
Davidson, Shawn M, Schmidt, Daniel R, Heyman, Julia E, O'Brien, James P, Liu, Amy C, Israelsen, William J, Dayton, Talya L, Sehgal, Raghav, Bronson, Roderick T, Freinkman, Elizaveta, Mak, Howard H, Fanelli, Giuseppe Nicolò, Malstrom, Scott, Bellinger, Gary, Carracedo, Arkaitz, Pandolfi, Pier Paolo, Courtney, Kevin D, Jha, Abhishek, DePinho, Ronald A, Horner, James W, Thomas, Craig J, Cantley, Lewis C, Loda, Massimo, Vander Heiden, Matthew G
Published in Cancer research (Chicago, Ill.) (05.07.2022)
Published in Cancer research (Chicago, Ill.) (05.07.2022)
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Journal Article
Nesting box imager: Contact-free, real-time measurement of activity, surface body temperature, and respiratory rate applied to hibernating mouse models
Kallmyer, Nathaniel E, Shin, Han Jong, Brem, Ethan A, Israelsen, William J, Reuel, Nigel F
Published in PLoS biology (24.07.2019)
Published in PLoS biology (24.07.2019)
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Journal Article
Pyruvate kinase: Function, regulation and role in cancer
Israelsen, William J., Vander Heiden, Matthew G.
Published in Seminars in cell & developmental biology (01.07.2015)
Published in Seminars in cell & developmental biology (01.07.2015)
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Journal Article
PKM2 is not required for colon cancer initiated by APC loss
Lau, Allison N, Israelsen, William J, Roper, Jatin, Sinnamon, Mark J, Georgeon, Larissa, Dayton, Talya L, Hillis, Alissandra L, Yilmaz, Omer H, Di Vizio, Dolores, Hung, Kenneth E, Vander Heiden, Matthew G
Published in Cancer & metabolism (30.11.2017)
Published in Cancer & metabolism (30.11.2017)
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Journal Article
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Palsson-McDermott, Eva M., Curtis, Anne M., Goel, Gautam, Lauterbach, Mario A.R., Sheedy, Frederick J., Gleeson, Laura E., van den Bosch, Mirjam W.M., Quinn, Susan R., Domingo-Fernandez, Raquel, Johnston, Daniel G.W., Jiang, Jian-kang, Israelsen, William J., Keane, Joseph, Thomas, Craig, Clish, Clary, Vander Heiden, Matthew, Xavier, Ramnik J., O’Neill, Luke A.J.
Published in Cell metabolism (03.02.2015)
Published in Cell metabolism (03.02.2015)
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Journal Article
Fibroblasts as an experimental model system for the study of comparative physiology
Madelaire, Carla B., Klink, Amy C., Israelsen, William J., Hindle, Allyson G.
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01.06.2022)
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01.06.2022)
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Journal Article
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.
Published in Cell (10.10.2013)
Published in Cell (10.10.2013)
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Journal Article
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Vander Heiden, Matthew G.
Published in FEBS letters (01.02.2020)
Published in FEBS letters (01.02.2020)
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Journal Article
Cutaneous Dermatophilosis in a Meadow Jumping Mouse (Zapus hudsonius)
Caron, Tyler J, Artim, Stephen C, Israelsen, William J, Holcombe, Hilda R, Fox, James G, Bakthavatchalu, Vasudevan
Published in Comparative medicine (01.02.2018)
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Published in Comparative medicine (01.02.2018)
Journal Article
2-Oxo- N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Israelsen, William J., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B.
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G
Published in Nature chemical biology (01.10.2012)
Published in Nature chemical biology (01.10.2012)
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Journal Article
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G
Published in Nature chemical biology (26.08.2012)
Published in Nature chemical biology (26.08.2012)
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Journal Article