Loading…
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans
Baker, Suzanne L, Provost, Karine, Thomas, Wesley, Whitman, AJ, Janabi, Mustafa, Schmidt, Mark E, Timmers, Maarten, Kolb, Hartmuth C, Rabinovici, Gil D, Jagust, William J
Published in Journal of cerebral blood flow and metabolism (01.12.2021)
Published in Journal of cerebral blood flow and metabolism (01.12.2021)
Get full text
Journal Article
Loading…
First‐in‐human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS‐962212, a direct, reversible, small molecule factor XIa inhibitor in non‐Japanese and Japanese healthy subjects
Perera, Vidya, Luettgen, Joseph M., Wang, Zhaoqing, Frost, Charles E., Yones, Cynthia, Russo, Cesare, Lee, John, Zhao, Yue, LaCreta, Frank P., Ma, Xuewen, Knabb, Robert M., Seiffert, Dietmar, DeSouza, Mary, Mugnier, Pierre, Cirincione, Brenda, Ueno, Takayo, Frost, Robert J. A.
Published in British Journal of Clinical Pharmacology (01.05.2018)
Published in British Journal of Clinical Pharmacology (01.05.2018)
Get full text
Journal Article
Loading…
Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans
Spencer, Andrew G, Labonte, Eric D, Rosenbaum, David P, Plato, Craig F, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Bell, Noah, Tabora, Jocelyn, Joly, Kristin M, Navre, Marc, Jacobs, Jeffrey W, Charmot, Dominique
Published in Science translational medicine (12.03.2014)
Published in Science translational medicine (12.03.2014)
Get more information
Journal Article
Loading…
Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Transiently Alters the Morphology of Corneal Endothelial Cells
Okumura, Naoki, Okazaki, Yugo, Inoue, Ryota, Nakano, Shinichiro, Fullwood, Nigel J., Kinoshita, Shigeru, Koizumi, Noriko
Published in Investigative ophthalmology & visual science (01.11.2015)
Published in Investigative ophthalmology & visual science (01.11.2015)
Get full text
Journal Article
Loading…
HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients
Canini, Laetitia, Imamura, Michio, Kawakami, Yoshiiku, Uprichard, Susan L., Cotler, Scott J., Dahari, Harel, Chayama, Kazuaki
Published in PloS one (07.12.2017)
Published in PloS one (07.12.2017)
Get full text
Journal Article
Loading…
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Kielbasa, William
Published in Clinical pharmacology in drug development (01.04.2021)
Published in Clinical pharmacology in drug development (01.04.2021)
Get full text
Journal Article
Loading…
Safety, Pharmacokinetic, and Pharmacodynamic Evaluation After Single and Multiple Ascending Doses of a Novel Selective Androgen Receptor Modulator in Healthy Subjects
Bhattacharya, Indranil, Tarabar, Sanela, Liang, Yali, Pradhan, Vivek, Owens, Jane, Oemar, Barry
Published in Clinical therapeutics (01.06.2016)
Published in Clinical therapeutics (01.06.2016)
Get full text
Journal Article
Loading…
Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195
Kang, Yeona, Schlyer, David, Kaunzner, Ulrike W., Kuceyeski, Amy, Kothari, Paresh J., Gauthier, Susan A.
Published in PloS one (09.08.2018)
Published in PloS one (09.08.2018)
Get full text
Journal Article
Loading…
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
Chen, Ruoli L., Ogunshola, O. O., Yeoh, Karkheng K., Jani, Anant, Papadakis, Michalis, Nagel, Simon, Schofield, Christopher J., Buchan, Alastair M.
Published in Journal of neurochemistry (01.10.2014)
Published in Journal of neurochemistry (01.10.2014)
Get full text
Journal Article
Loading…
Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study
Nakagawa, Hiroko, Koizumi, Noriko, Okumura, Naoki, Suganami, Hideki, Kinoshita, Shigeru
Published in PloS one (14.09.2015)
Published in PloS one (14.09.2015)
Get full text
Journal Article
Loading…
Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C
Pasquinelli, Claudio, McPhee, Fiona, Eley, Timothy, Villegas, Criselda, Sandy, Katrina, Sheridan, Pamela, Persson, Anna, Huang, Shu-Pang, Hernandez, Dennis, Sheaffer, Amy K., Scola, Paul, Marbury, Thomas, Lawitz, Eric, Goldwater, Ronald, Rodriguez-Torres, Maribel, DeMicco, Michael, Wright, David, Charlton, Michael, Kraft, Walter K., Lopez-Talavera, Juan-Carlos, Grasela, Dennis M.
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Get full text
Journal Article
Loading…
Effect of Kidney Function and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
Groenendaal-van de Meent, Dorien, Kerbusch, Virginie, Kaspera, Rudiger, Barroso-Fernandez, Begona, Galletti, Piergiorgio, Klein, Gernot K., den Adel, Martin
Published in European journal of drug metabolism and pharmacokinetics (01.01.2021)
Published in European journal of drug metabolism and pharmacokinetics (01.01.2021)
Get full text
Journal Article
Loading…
Investigation of the effect of the dual orexin receptor antagonist almorexant on ophthalmological, spermatogenic, and hormonal variables in healthy male subjects
Dingemanse, Jasper, Charef, Pascal, Black, Jed, Gouws, Chris
Published in Biomedicine & pharmacotherapy (01.01.2021)
Published in Biomedicine & pharmacotherapy (01.01.2021)
Get full text
Journal Article
Loading…
Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant
Hoever, P, de Haas, S, Winkler, J, Schoemaker, R C, Chiossi, E, van Gerven, J, Dingemanse, J
Published in Clinical pharmacology and therapeutics (01.05.2010)
Published in Clinical pharmacology and therapeutics (01.05.2010)
Get more information
Journal Article
Loading…
Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects
Groenendaal-van de Meent, Dorien, den Adel, Martin, van Dijk, Jan, Barroso-Fernandez, Begona, El Galta, Rachid, Golor, Georg, Schaddelee, Marloes
Published in European journal of drug metabolism and pharmacokinetics (01.12.2018)
Published in European journal of drug metabolism and pharmacokinetics (01.12.2018)
Get full text
Journal Article
Loading…
Effects of HM30181, a P‐glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers
Kim, Tae‐Eun, Lee, Howard, Lim, Kyoung Soo, Lee, SeungHwan, Yoon, Seo‐Hyun, Park, Kyung‐Mi, Han, Hyesun, Shin, Sang‐Goo, Jang, In‐Jin, Yu, Kyung‐Sang, Cho, Joo‐Youn
Published in British journal of clinical pharmacology (01.09.2014)
Published in British journal of clinical pharmacology (01.09.2014)
Get full text
Journal Article
Loading…
Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C
Kato, Keizo, Shimada, Noritomo, Atsukawa, Masanori, Abe, Hiroshi, Itokawa, Norio, Matsumoto, Yoshihiro, Agata, Rie, Tsubota, Akihito
Published in PloS one (10.07.2019)
Published in PloS one (10.07.2019)
Get full text
Journal Article
Loading…
Descemet Endothelial Thickness Comparison Trial II (DETECT II): multicentre, outcome assessor-masked, placebo-controlled trial comparing Descemet membrane endothelial keratoplasty (DMEK) to Descemet stripping only (DSO) with adjunctive ripasudil for Fuchs dystrophy
Lin, Charles C, Chamberlain, Winston, Benetz, Beth Ann, Gensheimer, William, Li, Jennifer Y, Jeng, Bennie H, Clover, Jameson, Varnado, Nicole, Abdelrahman, Sarah, Srinivasan, Amrita, Syed, Zeba A, Koo, Ellen H, Arnold, Benjamin F, Lietman, Thomas M, Lass, Jonathan, Rose-Nussbaumer, Jennifer
Published in BMJ open ophthalmology (01.10.2024)
Published in BMJ open ophthalmology (01.10.2024)
Get full text
Journal Article
Loading…
Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study
Muhlisah, Aisyah, Hirooka, Kazuyuki, Nurtania, Ariyanie, Onoe, Hiromitsu, Okumichi, Hideaki, Nitta, Eri, Baba, Tetsuya, Tanito, Masaki, Matsuoka, Yotaro, Nakakura, Shunsuke, Kiuchi, Yoshiaki
Published in BMJ open ophthalmology (02.07.2024)
Published in BMJ open ophthalmology (02.07.2024)
Get full text
Journal Article