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Published in Nature communications (15.10.2020)
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Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors
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Published in ACS medicinal chemistry letters (09.10.2014)
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Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase
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Published in Journal of neuroscience research (01.06.2011)
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Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases
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Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept
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Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Synthesis of Novel Benzo-Fused Heteroaryl Derivatives as Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitors
Komiya, Masafumi, Asano, Shigehiro, Koike, Nobuyuki, Koga, Erina, Igarashi, Junetsu, Nakatani, Shogo, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (2013)
Published in Chemical & pharmaceutical bulletin (2013)
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Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor
Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Horiguchi, Masakuni, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e] [1,4]diazepines with clozapine-like receptor occupancy at dopamine D-1/D-2 receptor
Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Horiguchi, Masakuni, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor
Tsuboi, Katsunori, Kimura, Hidenori, Nakatsuji, Yoshie, Kassai, Momoe, Deai, Yoko, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors
Kimura, Hidenori, Suda, Hitoshi, Kassai, Momoe, Endo, Mika, Deai, Yoko, Yahata, Masahiro, Miyajima, Mari, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
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Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: Potent Interferon Inducing Agents in Monkeys
Kurimoto, Ayumu, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Takaku, Haruo, Ichii, Shinji, Kawakami, Hajime, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Published in Chemical & pharmaceutical bulletin (01.04.2004)
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Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors
Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Nakako, Tomokazu, Horiguchi, Masakuni, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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