Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions
Natsugari, Hideaki, Ikeura, Yoshinori, Kamo, Izumi, Ishimaru, Takenori, Ishichi, Yuji, Fujishima, Akira, Tanaka, Toshimasa, Kasahara, Fumiko, Kawada, Mitsuru, Doi, Takayuki
Published in Journal of medicinal chemistry (23.09.1999)
Published in Journal of medicinal chemistry (23.09.1999)
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Journal Article
Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs
Nagabukuro, Hiroshi, Okanishi, Satoshi, Imai, Shigemitsu, Ishichi, Yuji, Ishihara, Yuji, Doi, Takayuki
Published in European journal of pharmacology (06.02.2004)
Published in European journal of pharmacology (06.02.2004)
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Journal Article
Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements
Ikeura, Yoshinori, Ishichi, Yuji, Tanaka, Toshimasa, Fujishima, Akira, Murabayashi, Mika, Kawada, Mitsuru, Ishimaru, Takenori, Kamo, Izumi, Doi, Takayuki, Natsugari, Hideaki
Published in Journal of medicinal chemistry (22.10.1998)
Published in Journal of medicinal chemistry (22.10.1998)
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Journal Article
Intramolecular carbon-carbon bond formation by the anodic oxidation of unsaturated .alpha.-stannyl heteroatom compounds. Synthesis of fluorine containing heterocyclic compounds
Yoshida, Junichi, Ishichi, Yuji, Isoe, Sachihiko
Published in Journal of the American Chemical Society (01.09.1992)
Published in Journal of the American Chemical Society (01.09.1992)
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Journal Article
Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor
Yukawa, Takafumi, Nakahata, Takashi, Okamoto, Rei, Ishichi, Yuji, Miyamoto, Yasufumi, Nishimura, Satoshi, Oikawa, Tatsuo, Kubo, Kazuki, Adachi, Ryutaro, Satomi, Yoshinori, Nakakariya, Masanori, Amano, Nobuyuki, Kamaura, Masahiro, Matsunaga, Nobuyuki
Published in Bioorganic & medicinal chemistry (01.04.2020)
Published in Bioorganic & medicinal chemistry (01.04.2020)
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Journal Article
Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist
Mochizuki, Michiyo, Kojima, Takuto, Kobayashi, Katsumi, Kotani, Etsuo, Ishichi, Yuji, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Okuda, Teruaki, Kosugi, Yohei, Yano, Takahiko, Sako, Yuu, Tanaka, Maiko, Aso, Kazuyoshi
Published in Bioorganic & medicinal chemistry (01.03.2017)
Published in Bioorganic & medicinal chemistry (01.03.2017)
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Journal Article
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3
Yukawa, Tomoya, Nakada, Yoshihisa, Sakauchi, Nobuki, Kamei, Taku, Yamada, Masami, Ohba, Yusuke, Fujimori, Ikuo, Ueno, Hiroyuki, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Fujioka, Yasushi, Igari, Tomoko, Ishichi, Yuji, Tsukamoto, Tetsuya
Published in Bioorganic & medicinal chemistry (15.08.2016)
Published in Bioorganic & medicinal chemistry (15.08.2016)
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Journal Article
Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine
Yamashita, Masayuki, Taya, Naohiro, Nishitani, Mitsuyoshi, Oda, Katsuaki, Kawamoto, Tetsuji, Kimura, Eiji, Ishichi, Yuji, Terauchi, Jun, Yamano, Toru
Published in Tetrahedron: asymmetry (15.09.2015)
Published in Tetrahedron: asymmetry (15.09.2015)
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Journal Article
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2
Yukawa, Tomoya, Fujimori, Ikuo, Kamei, Taku, Nakada, Yoshihisa, Sakauchi, Nobuki, Yamada, Masami, Ohba, Yusuke, Ueno, Hiroyuki, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Fujioka, Yasushi, Igari, Tomoko, Ishichi, Yuji, Tsukamoto, Tetsuya
Published in Bioorganic & medicinal chemistry (15.07.2016)
Published in Bioorganic & medicinal chemistry (15.07.2016)
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Journal Article
Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor
Fujimori, Ikuo, Yukawa, Tomoya, Kamei, Taku, Nakada, Yoshihisa, Sakauchi, Nobuki, Yamada, Masami, Ohba, Yusuke, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Hamada, Teruki, Igari, Tomoko, Okuda, Teruaki, Yamamoto, Satoshi, Tsukamoto, Tetsuya, Ishichi, Yuji, Ueno, Hiroyuki
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
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Journal Article
Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors
Honda, Eiji, Ishichi, Yuji, Kimura, Eiji, Yoshikawa, Masato, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Terao, Yasuko, Suzuki, Atsuko, Kawai, Takayuki, Arakawa, Yuuichi, Ohta, Hiroyuki, Terauchi, Jun
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds
Ishichi, Yuji, Kimura, Eiji, Honda, Eiji, Yoshikawa, Masato, Nakahata, Takashi, Terao, Yasuko, Suzuki, Atsuko, Kawai, Takayuki, Arakawa, Yuuichi, Ohta, Hiroyuki, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Terauchi, Jun
Published in Bioorganic & medicinal chemistry (01.08.2013)
Published in Bioorganic & medicinal chemistry (01.08.2013)
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Journal Article
HETEROCYCLIC COMPOUND
ISHICHI YUJI, KINA ASATO, SASAKI MINORU, TAKAKURA NOBUYUKI, KUBO OSAMU, YAMAZAKI TAKESHI, WATABE HIROSHI, SATO KENJIRO, MORIMOTO YUKIE, NISHIKAWA YOICHI, YAMASHITA TORU, TAKADA HIROYUKI, FUJIMOTO TAKUYA, IKOMA MINORU, KITAZAKI TOMOYUKI, KIKUCHI SHIRO
Year of Publication 25.06.2020
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Year of Publication 25.06.2020
Patent
HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
SUGIMOTO, Hiromichi, MARUI, Shogo, TOKUNAGA, Norihito, MIYAZAKI, Tohru, ODA, Tsuneo, TOMATA, Yoshihide, BANNO, Yoshihiro, ISHICHI, Yuji, MIYANOHANA, Yuhei, HATTORI, Yasushi, RIKIMARU, Kentaro, MATSUMOTO, Takahiro, FUJIMOTO, Tatsuhiko, FUKUDA, Koichiro, HOASHI, Yasutaka, KOIKE, Tatsuki, KAJITA, Yuichi
Year of Publication 02.01.2020
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Year of Publication 02.01.2020
Patent
Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF 1 receptor antagonist
Mochizuki, Michiyo, Kojima, Takuto, Kobayashi, Katsumi, Kotani, Etsuo, Ishichi, Yuji, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Okuda, Teruaki, Kosugi, Yohei, Yano, Takahiko, Sako, Yuu, Tanaka, Maiko, Aso, Kazuyoshi
Published in Bioorganic & medicinal chemistry (01.03.2017)
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Published in Bioorganic & medicinal chemistry (01.03.2017)
Journal Article
HETEROCYCLIC COMPOUND
KUBO, Osamu, IKOMA, Minoru, TAKADA, Hiroyuki, FUKUSHI, Hideto, TAKAKURA, Nobuyuki, SATO, Kenjiro, ISHICHI, Yuji, SASAKI, Minoru, MAEKAWA, Tsuyoshi, YAMASAKI, Takeshi, MORIMOTO, Sachie, HARA, Ryoma, YAMASHITA, Toru, KITAZAKI, Tomoyuki, KIKUCHI, Fumiaki, MATSUMOTO, Shigemitsu, KINA, Asato, NOGUCHI, Naoyoshi, WATANABE, Koji, NISHIKAWA, Yoichi, FUJIMOTO, Takuya, KOBAYASHI, Toshitake
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
Patent