An online resource for GPCR structure determination and analysis
Munk, Christian, Mutt, Eshita, Isberg, Vignir, Nikolajsen, Louise F, Bibbe, Janne M, Flock, Tilman, Hanson, Michael A, Stevens, Raymond C, Deupi, Xavier, Gloriam, David E
Published in Nature methods (01.02.2019)
Published in Nature methods (01.02.2019)
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Journal Article
GPCRdb: an information system for G protein-coupled receptors
Isberg, Vignir, Mordalski, Stefan, Munk, Christian, Rataj, Krzysztof, Harpsøe, Kasper, Hauser, Alexander S, Vroling, Bas, Bojarski, Andrzej J, Vriend, Gert, Gloriam, David E
Published in Nucleic acids research (04.01.2016)
Published in Nucleic acids research (04.01.2016)
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Journal Article
Generic GPCR residue numbers – aligning topology maps while minding the gaps
Isberg, Vignir, de Graaf, Chris, Bortolato, Andrea, Cherezov, Vadim, Katritch, Vsevolod, Marshall, Fiona H, Mordalski, Stefan, Pin, Jean-Philippe, Stevens, Raymond C, Vriend, Gerrit, Gloriam, David E
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2015)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2015)
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Journal Article
GPCRDB: an information system for G protein-coupled receptors
Isberg, Vignir, Vroling, Bas, van der Kant, Rob, Li, Kang, Vriend, Gert, Gloriam, David
Published in Nucleic acids research (01.01.2014)
Published in Nucleic acids research (01.01.2014)
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Journal Article
GPCRdb: an information system for G protein-coupled receptors
Isberg, Vignir, Mordalski, Stefan, Munk, Christian, Rataj, Krzysztof, Harpsøe, Kasper, Hauser, Alexander S, Vroling, Bas, Bojarski, Andrzej J, Vriend, Gert, Gloriam, David E
Published in Nucleic acids research (17.03.2017)
Published in Nucleic acids research (17.03.2017)
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Journal Article
Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants
Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G, Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H, Bräuner-Osborne, Hans, Gloriam, David E
Published in Scientific reports (11.09.2015)
Published in Scientific reports (11.09.2015)
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Journal Article
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site
Nøhr, Anne Cathrine, Jespers, Willem, Shehata, Mohamed A, Floryan, Leonard, Isberg, Vignir, Andersen, Kirsten Bayer, Åqvist, Johan, Gutiérrez-de-Terán, Hugo, Bräuner-Osborne, Hans, Gloriam, David E
Published in Scientific reports (25.04.2017)
Published in Scientific reports (25.04.2017)
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Journal Article
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Frandsen, Ida Osborn, Boesgaard, Michael W., Fidom, Kimberley, Hauser, Alexander S., Isberg, Vignir, Bräuner-Osborne, Hans, Wellendorph, Petrine, Gloriam, David E.
Published in Scientific reports (06.07.2017)
Published in Scientific reports (06.07.2017)
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Journal Article
G Protein- and Agonist-Bound Serotonin 5-HT2A Receptor Model Activated by Steered Molecular Dynamics Simulations
Ísberg, Vignir, Balle, Thomas, Sander, Tommy, Jørgensen, Flemming Steen, Gloriam, David E
Published in Journal of chemical information and modeling (28.02.2011)
Published in Journal of chemical information and modeling (28.02.2011)
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Journal Article
Integrating structural and mutagenesis data to elucidate GPCR ligand binding
Munk, Christian, Harpsøe, Kasper, Hauser, Alexander S, Isberg, Vignir, Gloriam, David E
Published in Current opinion in pharmacology (01.10.2016)
Published in Current opinion in pharmacology (01.10.2016)
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Journal Article
Computer-Aided Discovery of Aromatic l‑α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139
Isberg, Vignir, Andersen, Kirsten B, Bisig, Christoph, Dietz, Gunnar P. H, Bräuner-Osborne, Hans, Gloriam, David E
Published in Journal of chemical information and modeling (23.06.2014)
Published in Journal of chemical information and modeling (23.06.2014)
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Journal Article
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
Nøhr, Anne Cathrine, Shehata, Mohamed A., Hauser, Alexander S., Isberg, Vignir, Mokrosinski, Jacek, Andersen, Kirsten B., Farooqi, I. Sadaf, Pedersen, Daniel Sejer, Gloriam, David E., Bräuner-Osborne, Hans
Published in Neurochemistry international (01.01.2017)
Published in Neurochemistry international (01.01.2017)
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Journal Article
A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors
Fidom, Kimberley, Isberg, Vignir, Hauser, Alexander S., Mordalski, Stefan, Lehto, Thomas, Bojarski, Andrzej J., Gloriam, David E.
Published in Methods (San Diego, Calif.) (01.01.2015)
Published in Methods (San Diego, Calif.) (01.01.2015)
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Journal Article
Design, Synthesis, and Pharmacological Characterization of N- and O‑Substituted 5,6,7,8-Tetrahydro‑4H‑isoxazolo[4,5‑d]azepin-3-ol Analogues: Novel 5‑HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties
Jensen, Anders A, Plath, Niels, Pedersen, Martin H. F, Isberg, Vignir, Krall, Jacob, Wellendorph, Petrine, Stensbøl, Tine B, Gloriam, David E, Krogsgaard-Larsen, Povl, Frølund, Bente
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
Shehata, Mohamed A, Nøhr, Anne C, Lissa, Delphine, Bisig, Christoph, Isberg, Vignir, Andersen, Kirsten B, Harpsøe, Kasper, Björkling, Fredrik, Bräuner-Osborne, Hans, Gloriam, David E
Published in Scientific reports (10.11.2016)
Published in Scientific reports (10.11.2016)
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Journal Article
Computer-Aided Discovery of Aromatic l-[alpha]-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139
Isberg, Vignir, Andersen, Kirsten B, Bisig, Christoph, Dietz, Gunnar PH, Bräuner-Osborne, Hans, Gloriam, David E
Published in Journal of chemical information and modeling (23.06.2014)
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Published in Journal of chemical information and modeling (23.06.2014)
Journal Article
Generic GPCR Residue Numbers - Aligning Topology Maps Minding The Gaps
Isberg, Vignir, de Graaf, Chris, Bortolato, Andrea, Cherezov, Vadim, Katritch, Vsevolod, Marshall, Fiona H., Mordalski, Stefan, Pin, Jean-Philippe, Stevens, Raymond C., Vriend, Gerrit, Gloriam, David E.
Published in Trends in pharmacological sciences (Regular ed.) (22.12.2014)
Published in Trends in pharmacological sciences (Regular ed.) (22.12.2014)
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Journal Article