FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer
Oliveira, M., Saura, C., Nuciforo, P., Calvo, I., Andersen, J., Passos-Coelho, J.L., Gil Gil, M., Bermejo, B., Patt, D.A., Ciruelos, E., de la Peña, L., Xu, N., Wongchenko, M., Shi, Z., Singel, S.M., Isakoff, S.J.
Published in Annals of oncology (01.08.2019)
Published in Annals of oncology (01.08.2019)
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Neoadjuvant niraparib in patients with HER2-negative, BRCA-mutated resectable breast cancer
Spring, L.M., Han, H., Hamilton, E., Irie, H., Santa-Maria, C.A., Reeves, J., Pan, P., Shan, M., Tang, Y., Graham, J.R., Hazard, S., Ellisen, L.W., Isakoff, S.J.
Published in Breast (Edinburgh) (01.04.2021)
Published in Breast (Edinburgh) (01.04.2021)
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Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study
Han, H.S., Diéras, V., Robson, M., Palácová, M., Marcom, P.K., Jager, A., Bondarenko, I., Citrin, D., Campone, M., Telli, M.L., Domchek, S.M., Friedlander, M., Kaufman, B., Garber, J.E., Shparyk, Y., Chmielowska, E., Jakobsen, E.H., Kaklamani, V., Gradishar, W., Ratajczak, C.K., Nickner, C., Qin, Q., Qian, J., Shepherd, S.P., Isakoff, S.J., Puhalla, S.
Published in Annals of oncology (01.01.2018)
Published in Annals of oncology (01.01.2018)
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Phase I trial of olaparib in combination with cisplatin for the treatment of patients with advanced breast, ovarian and other solid tumors
Balmaña, J., Tung, N.M., Isakoff, S.J., Graña, B., Ryan, P.D., Saura, C., Lowe, E.S., Frewer, P., Winer, E., Baselga, J., Garber, J.E.
Published in Annals of oncology (01.08.2014)
Published in Annals of oncology (01.08.2014)
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A Phase I Study of Adjuvant Niraparib Administered Concurrently with Postoperative Radiation Therapy in Patients with Localized Triple Negative Breast Cancer
Keenan, J.C., Dunn, S.A., Collins, M.E., Taghian, A.G., Spring, L.M., Moy, B., Bardia, A., Kuter, I., Cho, H.L., Gadd, M.A., Vidula, N., Shin, J.A., Peppercorn, J.M., Bellon, J.R., Wong, J.S., Punglia, R.S., Tolaney, S., Isakoff, S.J., Ho, A.Y.
Published in International journal of radiation oncology, biology, physics (01.11.2022)
Published in International journal of radiation oncology, biology, physics (01.11.2022)
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Response-guided neoadjuvant sacituzumab govitecan for localized triple-negative breast cancer: results from the NeoSTAR trial
Spring, L.M., Tolaney, S.M., Fell, G., Bossuyt, V., Abelman, R.O., Wu, B., Maheswaran, S., Trippa, L., Comander, A., Mulvey, T., McLaughlin, S., Ryan, P., Ryan, L., Abraham, E., Rosenstock, A., Garrido-Castro, A.C., Lynce, F., Moy, B., Isakoff, S.J., Tung, N., Mittendorf, E.A., Ellisen, L.W., Bardia, A.
Published in Annals of oncology (01.03.2024)
Published in Annals of oncology (01.03.2024)
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Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors
Isakoff, S.J., Tabernero, J., Molife, L.R., Soria, J.-C., Cervantes, A., Vogelzang, N.J., Patel, M.R., Hussain, M., Baron, A., Argilés, G., Conkling, P.R., Sampath, D., Maslyar, D., Patel, P., Chan, W., Gendreau, S., Musib, L., Xu, N., Ma, H., Lin, K., Bendell, J.
Published in Annals of oncology (01.05.2020)
Published in Annals of oncology (01.05.2020)
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A Prospective Phase I trial of Concurrent Cisplatin (CIS) and Radiation Therapy (RT) in Women with Stage II and III Triple-negative Breast Cancer (TNBC)
Bellon, J.R., Chen, Y.H., Rees, R., Taghian, A.G., Wong, J.S., Punglia, R.S., Shiloh, R., Krishnan, M.S., Andrews, C., Isakoff, S.J., Winer, E., Tolaney, S.
Published in International journal of radiation oncology, biology, physics (01.09.2019)
Published in International journal of radiation oncology, biology, physics (01.09.2019)
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Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer
Diéras, V., Campone, M., Yardley, D.A., Romieu, G., Valero, V., Isakoff, S.J., Koeppen, H., Wilson, T.R., Xiao, Y., Shames, D.S., Mocci, S., Chen, M., Schmid, P.
Published in Annals of oncology (01.09.2015)
Published in Annals of oncology (01.09.2015)
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Local Therapy Outcomes and Toxicity From the ATEMPT Trial (TBCRC 033), a Phase II Randomized Trial of Adjuvant T-DM1 vs. TH in Women With Stage I HER2 Positive Breast Cancer
Bellon, J.R., Tayob, N., Burstein, H.J., Partridge, A., Demeo, M.K., Tralins, J., Yang, D.D., Dang, C., Isakoff, S.J., Yardley, D., Valero, V., Winer, E., Krop, I., Tolaney, S.
Published in International journal of radiation oncology, biology, physics (01.11.2021)
Published in International journal of radiation oncology, biology, physics (01.11.2021)
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139O Final results of the double-blind placebo (PBO)-controlled randomised phase II LOTUS trial of first-line ipatasertib (IPAT) + paclitaxel (PAC) for inoperable locally advanced/metastatic triple-negative breast cancer (mTNBC)
Dent, R., Oliveira, M., Isakoff, S.J., Im, S-A., Espié, M., Blau, S., Tan, A.R., Saura, C., Wongchenko, M., Xu, N., Bradley, D., Reilly, S-J., Mani, A., Kim, S-B.
Published in Annals of oncology (01.05.2020)
Published in Annals of oncology (01.05.2020)
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P095 - Neoadjuvant niraparib in patients with HER2-negative, BRCA-mutated resectable breast cancer
Spring, L.M., Han, H., Hamilton, E., Irie, H., Santa-Maria, C.A., Reeves, J., Pan, P., Shan, M., Tang, Y., Graham, J.R., Hazard, S., Ellisen, L.W., Isakoff, S.J.
Published in Breast (Edinburgh) (01.04.2021)
Published in Breast (Edinburgh) (01.04.2021)
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A systematic rapid autopsy program tracks temporal and spatial heterogeneity of human tumors and identifies mechanisms of resistance to targeted therapies
Walmsley, C.S., Juric, D., Bardia, A., Henderson, L., Gurski, J., Stone, J.R., Pinto, C., Isakoff, S.J., Fitzgerald, D.M., Gainor, J.F., Goyal, L., Broudo, M.
Published in Annals of oncology (01.09.2017)
Published in Annals of oncology (01.09.2017)
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446PDPHASE IB DOSE-ESCALATION STUDY OF THE AKT INHIBITOR IPATASERTIB (IPAT) WITH PACLITAXEL (P) IN PATIENTS (PTS) WITH ADVANCED SOLID TUMORS
Isakoff, S.J., Infante, J.R., Juric, D., Chan, W.Y., Jia, S., Musib, L., Zhu, J., Meng, R., Patel, P.H., Bendell, J.C.
Published in Annals of oncology (01.09.2014)
Published in Annals of oncology (01.09.2014)
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Phase Ib Dose-Escalation Study of the Akt Inhibitor Ipatasertib (Ipat) with Paclitaxel (P) in Patients (Pts) with Advanced Solid Tumors
Isakoff, S.J., Infante, J.R., Juric, D., Chan, W.Y., Jia, S., Musib, L., Zhu, J., Meng, R., Patel, P.H., Bendell, J.C.
Published in Annals of oncology (01.09.2014)
Published in Annals of oncology (01.09.2014)
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PI3K/AKT Activation and Response in Phase IB: AKT Inhibitor GDC-0068 with Docetaxel (D) Or MFOLFOX6 (F) in Refractory Solid Tumors
Meng, R., Molife, L.R., de Mattos-Arruda, L., Hollebecque, A., Isakoff, S.J., Roda, D., Yan, Y., Cervantes, A., Soria, J.C., Mateo, J., Argiles, G., Bendell, J.C.
Published in Annals of oncology (01.03.2013)
Published in Annals of oncology (01.03.2013)
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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
Isakoff, S.J, Cardozo, T, Andreev, J, Li, Z, Ferguson, K.M, Abagyan, R, Lemmon, M.A, Aronheim, A, Skolnick, E.Y
Published in The EMBO journal (15.09.1998)
Published in The EMBO journal (15.09.1998)
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The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake
Isakoff, S.J. (New York University Medical Center, New York, NY.), Taha, C, Rose, E, Marcusohn, J, Klip, A, Skolnik, E.Y
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.1995)
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The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes
Marcusohn, J., Isakoff, S.J., Rose, E., Symons, M., Skolnik, E.Y.
Published in Current biology (01.11.1995)
Published in Current biology (01.11.1995)
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