A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response
Gambardella, G., Viscido, G., Tumaini, B., Isacchi, A., Bosotti, R., di Bernardo, D.
Published in Nature communications (31.03.2022)
Published in Nature communications (31.03.2022)
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NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies
Ardini, E, Lombardi Borgia, A, Texido, G, Alzani, R, Avanzi, N, Amboldi, N, Cribioli, S, Mancini, L, Casero, D, Pastori, W, Montemartini, M, Montagnoli, A, Donati, D, Galvani, A, Isacchi, A, Ciomei, M
Published in European journal of cancer (1990) (01.12.2016)
Published in European journal of cancer (1990) (01.12.2016)
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PATRI, a Genomics Data Integration Tool for Biomarker Discovery
Callari, Maurizio, Cesarini, M., Della Vedova, G., Daidone, Maria Grazia, Pettenella, M., Isacchi, A., Bosotti, R., Leone, A., Vescovi, M., Pirchio, M. R., Di Bella, S., Rossi, P., Raddrizzani, L., Melloni, G. E. M., Ukmar, G., Somaschini, A.
Published in BioMed research international (01.01.2018)
Published in BioMed research international (01.01.2018)
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517 Identification and characterization of selective MELK kinase inhibitors
Carpinelli, P, Amboldi, N, Ballinari, D, Re Depaolini, S, Cucchi, U, Canevari, G, Caruso, M, Galli, R, Donati, D, Isacchi, A, Felder, E.R, Montagnoli, A, Galvani, A
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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309 Characterization of a Novel, Highly Potent and Selective RET Inhibitor with Antitumor Efficacy in RET Dependent Models
Ardini, E, Amboldi, N, Avanzi, N, Banfi, P, Cristiani, C, Donati, D, Galvani, A, Isacchi, A, Pesenti, E, Menichincheri, M
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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231 A Novel siRNA Screening Approach for Target Identification in Oncology: Focus On Purinome Enzymes
Gasparri, F, Carugo, A, Galvani, A, Gianellini, L.M, Giorgini, M.L, Isacchi, A, Lupi, R, Perrera, C, Raddrizzani, L, Colombo, R
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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Journal Article
Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling
Di Bartolo, V, Mège, D, Germain, V, Pelosi, M, Dufour, E, Michel, F, Magistrelli, G, Isacchi, A, Acuto, O
Published in The Journal of biological chemistry (05.03.1999)
Published in The Journal of biological chemistry (05.03.1999)
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Thermodynamics of the high-affinity interaction of TCF4 with β-catenin
Knapp, S, Zamai, M, Volpi, D, Nardese, V, Avanzi, N, Breton, J, Plyte, S, Flocco, M, Marconi, M, Isacchi, A, Caiolfa, V.R
Published in Journal of molecular biology (09.03.2001)
Published in Journal of molecular biology (09.03.2001)
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Early Th1 Response in Unprimed Nonobese Diabetic Mice to the Tyrosine Phosphatase-Like Insulinoma-Associated Protein 2, an Autoantigen in Type 1 Diabetes
Trembleau, Sylvie, Penna, Giuseppe, Gregori, Silvia, Magistrelli, Giovanni, Isacchi, Antonella, Adorini, Luciano
Published in The Journal of immunology (1950) (15.12.2000)
Published in The Journal of immunology (1950) (15.12.2000)
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385 A first in human phase 1 study of the safety and pharmacokinetics of a novel Cdc7 inhibitor NMS-1116354, administered orally to patients with solid tumors
Papadopoulos, K, Crippa, S, Hanssen, A, Montagnoli, A, Fiorentini, F, Tolcher, A.W, Martignoni, M, Isacchi, A, Laffranchi, B, Patnaik, A
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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147 Pharmacological characterization of NMS-P506, a novel second generation HSP90 inhibitor
Fogliatto, G, Mantegani, S, Amboldi, N, Ponti, A. De, Gianellini, L, Guanci, M, Paolucci, M, Donati, D, Pesenti, E, Isacchi, A
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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102 Identification and preclinical characterization of NMS-P626, a potent, selective and orally bioavailable TrkA inhibitor with anti-tumor activity in a TrkA-dependent colorectal cancer
Ardini, E, Borgia, A. Lombardi, Ponti, C. De, Amboldi, N, Ballinari, D, Saccardo, M.B, Magnaghi, P, Pesenti, E, Isacchi, A, Galvani, A
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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136 Activity of the Cdc7 inhibitor NMS-1116354 as single agent and in combination in breast cancer models
Montagnoli, A, Ballinari, D, Ciavolella, A, Rainoldi, S, Menichincheri, M, Pesenti, E, Galvani, A, Isacchi, A, Moll, J
Published in European journal of cancer supplements (2010)
Published in European journal of cancer supplements (2010)
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Journal Article
NMS-01940153E, an MPS1 inhibitor with anti-tumor activity in relapsed or refractory unresectable Hepatocellular carcinoma
Reig, M., Damian, S., Roberti, D., Maruzzelli, S., Crivori, P., Gianellini, L., De Pietro, M.T., Personeni, N., Sanduzzi-Zamparelli, M., Duca, M., Disconzi, L., Montagnoli, A., Galvani, A., Ardini, E., Isacchi, A., Colajori, E., Davite, C., Mahnke, L., Rimassa, L.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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Journal Article
NMS-173, a potent, covalent second generation IDH1/IDH2 inhibitor
Magnaghi, P., Casuscelli, F., Ardini, E., Parazzoli, A., Troiani, S., Valsasina, B., Texido, G., Casale, E., Avanzi, N., Orsini, P., Nuvoloni, S., Salom, B., Lombardi Borgia, A., Salsi, E., Saturno, G.S., Re Depaolini, S., Stellato, C., Montagnoli, A., Galvani, A., Isacchi, A.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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Expression of PTP35, the Murine Homolog of the Protein Tyrosine Phosphatase-Related Sequence IA-2, Is Regulated during Cell Growth and Stimulated by Mitogens in 3T3 Fibroblasts
Magistrelli, G., Covini, N., Mosca, M., Lippoli, G., Isacchi, A.
Published in Biochemical and biophysical research communications (05.12.1995)
Published in Biochemical and biophysical research communications (05.12.1995)
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FAT: a novel domain in PIK-related kinases
Bosotti, R, Isacchi, A, Sonnhammer, E L
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.05.2000)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.05.2000)
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Journal Article
A Six-Amino Acid Deletion in Basic Fibroblast Growth Factor Dissociates its Mitogenic Activity from its Plasminogen Activator-Inducing Capacity
Isacchi, Antonella, Statuto, Massimo, Chiesa, Roberta, Bergonzoni, Laura, Rusnati, Marco, Sarmientos, Paolo, Ragnotti, Giovanni, Presta, Marco
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1991)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1991)
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Journal Article
Basic fibroblast growth factor in Dupuytren's contracture
Gonzalez, AM, Buscaglia, M, Fox, R, Isacchi, A, Sarmientos, P, Farris, J, Ong, M, Martineau, D, Lappi, DA, Baird, A
Published in The American journal of pathology (01.09.1992)
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Published in The American journal of pathology (01.09.1992)
Journal Article
388 - NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies
Ardini, E., Lombardi Borgia, A., Texido, G., Alzani, R., Avanzi, N., Amboldi, N., Cribioli, S., Mancini, L., Casero, D., Pastori, W., Montemartini, M., Montagnoli, A., Donati, D., Galvani, A., Isacchi, A., Ciomei, M.
Published in European journal of cancer (1990) (01.12.2016)
Published in European journal of cancer (1990) (01.12.2016)
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