Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface
Liu, Lei, Fan, Zhiran, Rovira, Xavier, Xue, Li, Roux, Salomé, Brabet, Isabelle, Xin, Mingxia, Pin, Jean-Philippe, Rondard, Philippe, Liu, Jianfeng
Published in eLife (06.12.2021)
Published in eLife (06.12.2021)
Get full text
Journal Article
Virtual Screening Workflow Development Guided by the “Receiver Operating Characteristic” Curve Approach. Application to High-Throughput Docking on Metabotropic Glutamate Receptor Subtype 4
Triballeau, Nicolas, Acher, Francine, Brabet, Isabelle, Pin, Jean-Philippe, Bertrand, Hugues-Olivier
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
Get full text
Journal Article
Allosteric modulation of metabotropic glutamate receptors by chloride ions
Tora, Amélie S, Rovira, Xavier, Dione, Ibrahima, Bertrand, Hugues-Olivier, Brabet, Isabelle, De Koninck, Yves, Doyon, Nicolas, Pin, Jean-Philippe, Acher, Francine, Goudet, Cyril
Published in The FASEB journal (01.10.2015)
Published in The FASEB journal (01.10.2015)
Get more information
Journal Article
Molecular Determinants Involved in the Allosteric Control of Agonist Affinity in the GABAB Receptor by the GABAB2 Subunit
Liu, Jianfeng, Maurel, Damien, Etzol, Sébastien, Brabet, Isabelle, Ansanay, Hervé, Pin, Jean-Philippe, Rondard, Philippe
Published in The Journal of biological chemistry (16.04.2004)
Published in The Journal of biological chemistry (16.04.2004)
Get full text
Journal Article
Closure of the Venus Flytrap Module of mGlu8 Receptor and the Activation Process: Insights from Mutations Converting Antagonists into Agonists
Bessis, Anne-Sophie, Rondard, Philippe, Gaven, Florence, Brabet, Isabelle, Triballeau, Nicolas, Prézeau, Laurent, Acher, Francine, Pin, Jean-Philippe
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2002)
Get full text
Journal Article
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15
Masdeu, Christelle, Faure, Hélène, Coulombe, Josée, Schoenfelder, Angèle, Mann, André, Brabet, Isabelle, Pin, Jean-Philippe, Traiffort, Elisabeth, Ruat, Martial
Published in Biochemical and biophysical research communications (20.10.2006)
Published in Biochemical and biophysical research communications (20.10.2006)
Get full text
Journal Article
Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8
Corti, Corrado, Restituito, Sophie, Rimland, Joseph M., Brabet, Isabelle, Corsi, Mauro, Pin, Jean Philippe, Ferraguti, Francesco
Published in The European journal of neuroscience (01.12.1998)
Published in The European journal of neuroscience (01.12.1998)
Get full text
Journal Article
Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes
Acher, Francine C, Tellier, Frédérique J, Azerad, Robert, Brabet, Isabelle N, Fagni, Laurent, Pin, Jean-Philippe R
Published in Journal of medicinal chemistry (12.09.1997)
Published in Journal of medicinal chemistry (12.09.1997)
Get full text
Journal Article
Design, Synthesis, Pharmacology, and In Silico Studies of (1 S ,2 S ,3 S )-2-(( S )-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu 2 Receptor Agonist
Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine C, Staudt, Markus, Bunch, Lennart
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
Get full text
Journal Article
Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)‑2-((S)‑Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist
Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine C., Staudt, Markus, Bunch, Lennart
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
Get full text
Journal Article
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
Pin, Jean-Philippe, Mouillac, Bernard, Durroux, Thierry, Albizu, Laura, Cottet, Martin, Kralikova, Michaela, Stoev, Stoytcho, Seyer, René, Brabet, Isabelle, Roux, Thomas, Bazin, Hervé, Bourrier, Emmanuel, Lamarque, Laurent, Breton, Christophe, Rives, Marie-Laure, Newman, Amy, Javitch, Jonathan, Trinquet, Eric, Manning, Maurice
Published in Nature chemical biology (01.08.2010)
Published in Nature chemical biology (01.08.2010)
Get full text
Journal Article
Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain
Cristiano, Nunzia, Cabayé, Alexandre, Brabet, Isabelle, Glatthar, Ralf, Tora, Amelie, Goudet, Cyril, Bertrand, Hugues-Olivier, Goupil-Lamy, Anne, Flor, Peter J., Pin, Jean-Philippe, McCort-Tranchepain, Isabelle, Acher, Francine C.
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
Get full text
Journal Article
Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor
Hajj, Mariana, De Vita, Teresa, Vol, Claire, Renassia, Charlotte, Bologna, Jean-Charles, Brabet, Isabelle, Cazade, Magali, Pastore, Manuela, Blahos, Jaroslav, Labesse, Gilles, Pin, Jean-Philippe, Prézeau, Laurent
Published in Molecular pharmacology (01.08.2019)
Published in Molecular pharmacology (01.08.2019)
Get full text
Journal Article
Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR
Hajj, Mariana, de Vita, Teresa, Vol, Claire, Renassia, Charlotte, Bologna, Jean-Charles, Brabet, Isabelle, Cazade, Magali, Pastore, Manuela, Blahos, Jaroslav, Labesse, Gilles, Pin, Jean-Philippe, Prézeau, Laurent
Published in Molecular pharmacology (12.06.2019)
Published in Molecular pharmacology (12.06.2019)
Get full text
Journal Article
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential
Goudet, Cyril, Vilar, Bruno, Courtiol, Tiphanie, Deltheil, Thierry, Bessiron, Thomas, Brabet, Isabelle, Oueslati, Nadia, Rigault, Delphine, Bertrand, Hugues-Olivier, McLean, Heather, Daniel, Hervé, Amalric, Marianne, Acher, Francine, Pin, Jean-Philippe
Published in The FASEB journal (01.04.2012)
Published in The FASEB journal (01.04.2012)
Get more information
Journal Article
LSP5-2157 a new inhibitor of vesicular glutamate transporters
Poirel, Odile, Mamer, Lauren E., Herman, Melissa A., Arnulf-Kempcke, Marie, Kervern, Myriam, Potier, Brigitte, Miot, Stephanie, Wang, Jing, Favre-Besse, Franck-Cyril, Brabet, Isabelle, Laras, Younès, Bertrand, Hugues-Olivier, Acher, Francine, Pin, Jean-Philippe, Puel, Jean-Luc, Giros, Bruno, Epelbaum, Jacques, Rosenmund, Christian, Dutar, Patrick, Daumas, Stephanie, El Mestikawy, Salah, Pietrancosta, Nicolas
Published in Neuropharmacology (01.03.2020)
Published in Neuropharmacology (01.03.2020)
Get full text
Journal Article
A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists
Selvam, Chelliah, Oueslati, Nadia, Lemasson, Isabelle A, Brabet, Isabelle, Rigault, Delphine, Courtiol, Tiphanie, Cesarini, Sara, Triballeau, Nicolas, Bertrand, Hugues-Olivier, Goudet, Cyril, Pin, Jean-Philippe, Acher, Francine C
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
Get full text
Journal Article