Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure
NDAO, Momar, BEAULIEU, Christian, BLACK, W. Cameron, ISABEL, Elise, VASQUEZ-CAMARGO, Fabio, NATH-CHOWDHURY, Milli, MASSE, Frédéric, MELLON, Christophe, METHOT, Nathalie, NICOLL-GRIFFITH, Deborah A
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
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Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
Beaulieu, Christian, Isabel, Elise, Fortier, Angélique, Massé, Frédéric, Mellon, Christophe, Méthot, Nathalie, Ndao, Momar, Nicoll-Griffith, Deborah, Lee, Doris, Park, Hyeram, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Preparation, Solid-State Structure, and Synthetic Applications of Isolable and Storable Haloalkylzinc Reagents
Charette, André B, Marcoux, Jean-François, Molinaro, Carmela, Beauchemin, André, Brochu, Christian, Isabel, Élise
Published in Journal of the American Chemical Society (10.05.2000)
Published in Journal of the American Chemical Society (10.05.2000)
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Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series
Lachance, Nicolas, Gareau, Yves, Guiral, Sébastien, Huang, Zheng, Isabel, Elise, Leclerc, Jean-Philippe, Léger, Serge, Martins, Evelyn, Nadeau, Christian, Oballa, Renata M., Ouellet, Stéphane G., Powell, David A., Ramtohul, Yeeman K., Tranmer, Geoffrey K., Trinh, Thao, Wang, Hao, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy
Powell, David A., Black, W. Cameron, Bleasby, Kelly, Chan, Chi-Chung, Deschenes, Denis, Gagnon, Marc, Gordon, Rob, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J., Huang, Zheng, Isabel, Elise, Leblanc, Yves, Styhler, Angela, Xu, Li-Jing, Zhang, Lei, Oballa, Renata M.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Journal Article
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors
Isabel, Elise, Powell, David A., Black, W. Cameron, Chan, Chi-Chung, Crane, Sheldon, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Huang, Zheng, Robichaud, Joël, Skorey, Kathryn, Tawa, Paul, Xu, Lijing, Zhang, Lei, Oballa, Renata
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors
Ramtohul, Yeeman K., Powell, David, Leclerc, Jean-Philippe, Leger, Serge, Oballa, Renata, Black, Cameron, Isabel, Elise, Li, Chun Sing, Crane, Sheldon, Robichaud, Joel, Guay, Jocelyne, Guiral, Sébastien, Zhang, Lei, Huang, Zheng
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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High-throughput scintillation proximity assay for stearoyl-CoA desaturase-1
Tawa, Paul, Falgueyret, Jean-Pierre, Guiral, Sebastien, Isabel, Elise, Powell, David A, Zuck, Paul, Skorey, Kathryn
Published in Journal of biomolecular screening (01.06.2011)
Published in Journal of biomolecular screening (01.06.2011)
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Journal Article
Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis
Robichaud, Jöel, Black, W. Cameron, Thérien, Michel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Wang, Qingping, Isabel, Elise, Léger, Serge, Mellon, Christophe, Kimmel, Donald B, Wesolowski, Gregg, Percival, M. David, Massé, Fréderic, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Crane, Sheldon N
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones
Isabel, Elise, Aspiotis, Renee, Black, W. Cameron, Colucci, John, Fortin, Réjean, Giroux, André, Grimm, Erich L., Han, Yongxin, Mellon, Christophe, Nicholson, Donald W., Rasper, Dita M., Renaud, Johanne, Roy, Sophie, Tam, John, Tawa, Paul, Vaillancourt, John P., Xanthoudakis, Steven, Zamboni, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors
MELLON, Christophe, ASPIOTIS, Reneé, RASPER, Dita M, ROY, Sophie, TAM, John, THORNBERRY, Nancy A, VAILLANCOURT, John P, XANTHOUDAKIS, Steven, ZAMBONI, Robert, BLACK, Cameron W, BAYLY, Christopher I, GRIMM, Erich L, GIROUX, André, YONGXIN HAN, ISABEL, Elise, MCKAY, Daniel J, NICHOLSON, Donald W
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
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Journal Article
Nicotinyl aspartyl ketones as inhibitors of caspase-3
Isabel, Elise, Black, W.Cameron, Bayly, Christopher I, Grimm, Erich L, Janes, Marc K, McKay, Daniel J, Nicholson, Donald W, Rasper, Dita M, Renaud, Johanne, Roy, Sophie, Tam, John, Thornberry, Nancy A, Vaillancourt, John P, Xanthoudakis, Steven, Zamboni, Robert
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
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Journal Article
Lipophilic versus hydrogen-bonding effect in P 3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors
Mellon, Christophe, Aspiotis, Reneé, Black, Cameron W., Bayly, Christopher I., Grimm, Erich L., Giroux, André, Han, Yongxin, Isabel, Elise, McKay, Daniel J., Nicholson, Donald W., Rasper, Dita M., Roy, Sophie, Tam, John, Thornberry, Nancy A., Vaillancourt, John P., Xanthoudakis, Steven, Zamboni, Robert
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
Published in Bioorganic & medicinal chemistry letters (01.09.2005)
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