Ageing as a risk factor for ALS/FTD
Niccoli, Teresa, Partridge, Linda, Isaacs, Adrian M
Published in Human molecular genetics (01.10.2017)
Published in Human molecular genetics (01.10.2017)
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Journal Article
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates
Laferrière, Florent, Maniecka, Zuzanna, Pérez-Berlanga, Manuela, Hruska-Plochan, Marian, Gilhespy, Larissa, Hock, Eva-Maria, Wagner, Ulrich, Afroz, Tariq, Boersema, Paul J., Barmettler, Gery, Foti, Sandrine C., Asi, Yasmine T., Isaacs, Adrian M., Al-Amoudi, Ashraf, Lewis, Amanda, Stahlberg, Henning, Ravits, John, De Giorgi, Francesca, Ichas, François, Bezard, Erwan, Picotti, Paola, Lashley, Tammaryn, Polymenidou, Magdalini
Published in Nature neuroscience (01.01.2019)
Published in Nature neuroscience (01.01.2019)
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Journal Article
G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
Simone, Roberto, Fratta, Pietro, Neidle, Stephen, Parkinson, Gary N., Isaacs, Adrian M.
Published in FEBS letters (22.06.2015)
Published in FEBS letters (22.06.2015)
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Journal Article
C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
Rohrer, Jonathan D, Dr, Isaacs, Adrian M, PhD, Mizielinska, Sarah, PhD, Mead, Simon, Prof, Lashley, Tammaryn, PhD, Wray, Selina, PhD, Sidle, Katie, PhD, Fratta, Pietro, PhD, Orrell, Richard W, MD, Hardy, John, Prof, Holton, Janice, PhD, Revesz, Tamas, Prof, Rossor, Martin N, Prof, Warren, Jason D, Prof
Published in Lancet neurology (01.03.2015)
Published in Lancet neurology (01.03.2015)
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Journal Article
Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK Population
Beck, Jon, Poulter, Mark, Hensman, Davina, Rohrer, Jonathan D., Mahoney, Colin J., Adamson, Gary, Campbell, Tracy, Uphill, James, Borg, Aaron, Fratta, Pietro, Orrell, Richard W., Malaspina, Andrea, Rowe, James, Brown, Jeremy, Hodges, John, Sidle, Katie, Polke, James M., Houlden, Henry, Schott, Jonathan M., Fox, Nick C., Rossor, Martin N., Tabrizi, Sarah J., Isaacs, Adrian M., Hardy, John, Warren, Jason D., Collinge, John, Mead, Simon
Published in American journal of human genetics (07.03.2013)
Published in American journal of human genetics (07.03.2013)
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Journal Article
Genetic models of C9orf72 : what is toxic?
Moens, Thomas G, Partridge, Linda, Isaacs, Adrian M
Published in Current opinion in genetics & development (01.06.2017)
Published in Current opinion in genetics & development (01.06.2017)
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Journal Article
Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
Falcon, Benjamin, Cavallini, Annalisa, Angers, Rachel, Glover, Sarah, Murray, Tracey K., Barnham, Luanda, Jackson, Samuel, O'Neill, Michael J., Isaacs, Adrian M., Hutton, Michael L., Szekeres, Philip G., Goedert, Michel, Bose, Suchira
Published in The Journal of biological chemistry (09.01.2015)
Published in The Journal of biological chemistry (09.01.2015)
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Journal Article
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci
Mizielinska, Sarah, Lashley, Tammaryn, Norona, Frances E., Clayton, Emma L., Ridler, Charlotte E., Fratta, Pietro, Isaacs, Adrian M.
Published in Acta neuropathologica (01.12.2013)
Published in Acta neuropathologica (01.12.2013)
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Journal Article
Quantitative analysis of cryptic splicing associated with TDP-43 depletion
Humphrey, Jack, Emmett, Warren, Fratta, Pietro, Isaacs, Adrian M, Plagnol, Vincent
Published in BMC medical genomics (26.05.2017)
Published in BMC medical genomics (26.05.2017)
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Journal Article
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Mizielinska, Sarah, Grönke, Sebastian, Niccoli, Teresa, Ridler, Charlotte E., Clayton, Emma L., Devoy, Anny, Moens, Thomas, Norona, Frances E., Woollacott, Ione O. C., Pietrzyk, Julian, Cleverley, Karen, Nicoll, Andrew J., Pickering-Brown, Stuart, Dols, Jacqueline, Cabecinha, Melissa, Hendrich, Oliver, Fratta, Pietro, Fisher, Elizabeth M. C., Partridge, Linda, Isaacs, Adrian M.
Published in Science (American Association for the Advancement of Science) (05.09.2014)
Published in Science (American Association for the Advancement of Science) (05.09.2014)
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Journal Article
G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
Simone, Roberto, Balendra, Rubika, Moens, Thomas G, Preza, Elisavet, Wilson, Katherine M, Heslegrave, Amanda, Woodling, Nathan S, Niccoli, Teresa, Gilbert‐Jaramillo, Javier, Abdelkarim, Samir, Clayton, Emma L, Clarke, Mica, Konrad, Marie‐Therese, Nicoll, Andrew J, Mitchell, Jamie S, Calvo, Andrea, Chio, Adriano, Houlden, Henry, Polke, James M, Ismail, Mohamed A, Stephens, Chad E, Vo, Tam, Farahat, Abdelbasset A, Wilson, W David, Boykin, David W, Zetterberg, Henrik, Partridge, Linda, Wray, Selina, Parkinson, Gary, Neidle, Stephen, Patani, Rickie, Fratta, Pietro, Isaacs, Adrian M
Published in EMBO molecular medicine (01.01.2018)
Published in EMBO molecular medicine (01.01.2018)
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Journal Article
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
Humphrey, Jack, Birsa, Nicol, Milioto, Carmelo, McLaughlin, Martha, Ule, Agnieszka M, Robaldo, David, Eberle, Andrea B, Kräuchi, Rahel, Bentham, Matthew, Brown, Anna-Leigh, Jarvis, Seth, Bodo, Cristian, Garone, Maria G, Devoy, Anny, Soraru, Gianni, Rosa, Alessandro, Bozzoni, Irene, Fisher, Elizabeth M C, Mühlemann, Oliver, Schiavo, Giampietro, Ruepp, Marc-David, Isaacs, Adrian M, Plagnol, Vincent, Fratta, Pietro
Published in Nucleic acids research (09.07.2020)
Published in Nucleic acids research (09.07.2020)
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Journal Article
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
Fratta, Pietro, Mizielinska, Sarah, Nicoll, Andrew J., Zloh, Mire, Fisher, Elizabeth M. C., Parkinson, Gary, Isaacs, Adrian M.
Published in Scientific reports (21.12.2012)
Published in Scientific reports (21.12.2012)
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Journal Article
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
Yamada, Shizuka B., Gendron, Tania F., Niccoli, Teresa, Genuth, Naomi R., Grosely, Rosslyn, Shi, Yingxiao, Glaria, Idoia, Kramer, Nicholas J., Nakayama, Lisa, Fang, Shirleen, Dinger, Tai J. I., Thoeng, Annora, Rocha, Gabriel, Barna, Maria, Puglisi, Joseph D., Partridge, Linda, Ichida, Justin K., Isaacs, Adrian M., Petrucelli, Leonard, Gitler, Aaron D.
Published in Nature neuroscience (01.09.2019)
Published in Nature neuroscience (01.09.2019)
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