The multifunctional role of filaggrin in allergic skin disease
McAleer, Maeve A., MRCP, Irvine, Alan D., MD, FRCPI
Published in Journal of allergy and clinical immunology (01.02.2013)
Published in Journal of allergy and clinical immunology (01.02.2013)
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Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year
Kennedy, Elizabeth A., BS, Connolly, Jennifer, MSc, Hourihane, Jonathan O'B., DM, Fallon, Padraic G., PhD, McLean, W.H. Irwin, DSc, FRS, Murray, Deirdre, PhD, Jo, Jay-Hyun, PhD, Segre, Julia A., PhD, Kong, Heidi H., MD, MHSc, Irvine, Alan D., MD, DSc
Published in Journal of allergy and clinical immunology (01.01.2017)
Published in Journal of allergy and clinical immunology (01.01.2017)
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Journal Article
Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year
Kelleher, Maeve, MB, Dunn-Galvin, Audrey, PhD, Hourihane, Jonathan O'B., DM, Murray, Deirdre, MD, Campbell, Linda E., BSc, McLean, W.H. Irwin, DSc, FRS, Irvine, Alan D., MD
Published in Journal of allergy and clinical immunology (01.04.2015)
Published in Journal of allergy and clinical immunology (01.04.2015)
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Journal Article
Skin barrier impairment at birth predicts food allergy at 2 years of age
Kelleher, Maeve M., MD, Dunn-Galvin, Audrey, PhD, Gray, Claire, RN, Murray, Deirdre M., MD, PhD, Kiely, Mairead, PhD, Kenny, Louise, PhD, McLean, W.H. Irwin, PhD, FRS, Irvine, Alan D., MD, PhD, Hourihane, Jonathan O'B., DM
Published in Journal of allergy and clinical immunology (01.04.2016)
Published in Journal of allergy and clinical immunology (01.04.2016)
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Journal Article
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 ( STAT1 ) mutation
Higgins, Eleanor, MRCPI, Al Shehri, Tariq, MSc, McAleer, Maeve A., MRCPI, Conlon, Niall, PhD, FRCPath, Feighery, Conleth, MD, Lilic, Desa, MD, PhD, Irvine, Alan D., MD
Published in Journal of allergy and clinical immunology (01.02.2015)
Published in Journal of allergy and clinical immunology (01.02.2015)
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
Schmitt, Jochen, MD, MPH, Schwarz, Kristin, MSc, Baurecht, Hansjörg, MSc, Hotze, Melanie, MSc, Fölster-Holst, Regina, MD, Rodríguez, Elke, PhD, Lee, Young A.E., MD, Franke, Andre, PhD, Degenhardt, Frauke, MSc, Lieb, Wolfgang, PhD, Gieger, Christian, PhD, Kabesch, Michael, MD, Nöthen, Markus M., MD, Irvine, Alan D., MD, McLean, W.H. Irwin, PhD, Deckert, Stefanie, MPH, Stephan, Victoria, Schwarz, Peter, MD, Aringer, Martin, MD, Novak, Natalija, MD, Weidinger, Stephan, MD, MaHM
Published in Journal of allergy and clinical immunology (01.01.2016)
Published in Journal of allergy and clinical immunology (01.01.2016)
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Journal Article
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity
Saunders, Sean P., PhD, Moran, Tara, BSc, Floudas, Achilleas, PhD, Wurlod, Felicity, MSc, Kaszlikowska, Agnieszka, BSc, Salimi, Maryam, PhD, Quinn, Emma M., PhD, Oliphant, Christopher J., PhD, Núñez, Gabriel, MD, McManus, Ross, PhD, Hams, Emily, PhD, Irvine, Alan D., MD, McKenzie, Andrew N.J., PhD, Ogg, Graham S., MD, Fallon, Padraic G., PhD
Published in Journal of allergy and clinical immunology (01.02.2016)
Published in Journal of allergy and clinical immunology (01.02.2016)
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Journal Article
Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease
Rodríguez, Elke, MSc, Baurecht, Hansjörg, MSc, Herberich, Esther, Wagenpfeil, Stefan, PhD, Brown, Sara J., MD, Cordell, Heather J., BA, MSc, DPhil, Irvine, Alan D., MD, Weidinger, Stephan, MD
Published in Journal of allergy and clinical immunology (01.06.2009)
Published in Journal of allergy and clinical immunology (01.06.2009)
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Journal Article
Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis
Riethmuller, Christoph, PhD, McAleer, Maeve A., MRCP, Koppes, Sjors A., MD, Abdayem, Rawad, MSc, Franz, Jonas, Haftek, Marek, MD, PhD, Campbell, Linda E., MSc, MacCallum, Stephanie F., BSc, McLean, W.H. Irwin, PhD, DSc, FRS, FRSE, FMedSci, Irvine, Alan D., MD, Kezic, Sanja, PhD
Published in Journal of allergy and clinical immunology (01.12.2015)
Published in Journal of allergy and clinical immunology (01.12.2015)
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Journal Article
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis
Cole, Christian, PhD, Kroboth, Karin, MSc, Schurch, Nicholas J., PhD, Sandilands, Aileen, PhD, Sherstnev, Alexander, PhD, O'Regan, Grainne M., MRCPI, Watson, Rosemarie M., MD, Irwin McLean, W.H., DSc, Barton, Geoffrey J., PhD, Irvine, Alan D., MD, Brown, Sara J., MD
Published in Journal of allergy and clinical immunology (01.07.2014)
Published in Journal of allergy and clinical immunology (01.07.2014)
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Journal Article
Systemic therapies for severe atopic dermatitis in children and adults
Flohr, Carsten, MD, PhD, Irvine, Alan D., MD, FRCPI
Published in Journal of allergy and clinical immunology (01.09.2013)
Published in Journal of allergy and clinical immunology (01.09.2013)
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Journal Article
Filaggrin in atopic dermatitis
O'Regan, Grainne M., MB, Sandilands, Aileen, PhD, McLean, W.H. Irwin, PhD, DSc, Irvine, Alan D., MD, FRCPI
Published in Journal of allergy and clinical immunology (01.10.2008)
Published in Journal of allergy and clinical immunology (01.10.2008)
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Journal Article
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
Brown, Sara J., MD, Asai, Yuka, MD, Cordell, Heather J., DPhil, Campbell, Linda E., MSc, Zhao, Yiwei, MD, PhD, Liao, Haihui, MD, PhD, Northstone, Kate, PhD, Henderson, John, MD, Alizadehfar, Reza, MD, Ben-Shoshan, Moshe, MD, Morgan, Kenneth, PhD, Roberts, Graham, DM, Masthoff, Laury J.N., MD, Pasmans, Suzanne G.M.A., MD, PhD, van den Akker, Peter C., MD, Wijmenga, Cisca, PhD, Hourihane, Jonathan O’B., PhD, Palmer, Colin N.A., PhD, Lack, Gideon, PhD, Clarke, Ann, MD, MSc, Hull, Peter R., MD, PhD, Irvine, Alan D., MD, McLean, W. H. Irwin, PhD, DSc
Published in Journal of allergy and clinical immunology (01.03.2011)
Published in Journal of allergy and clinical immunology (01.03.2011)
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Journal Article
Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes
Domínguez-Hüttinger, Elisa, PhD, Christodoulides, Panayiotis, MEng, Miyauchi, Kosuke, PhD, Irvine, Alan D., MD, DSc, Okada-Hatakeyama, Mariko, PhD, Kubo, Masato, PhD, Tanaka, Reiko J., PhD
Published in Journal of allergy and clinical immunology (01.06.2017)
Published in Journal of allergy and clinical immunology (01.06.2017)
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Journal Article
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
Kezic, Sanja, PhD, O’Regan, Gráinne M., MRCPI, Lutter, René, PhD, Jakasa, Ivone, PhD, Koster, Ellen S., PhD, Saunders, Sean, BSc, Caspers, Peter, PhD, Kemperman, Patrick M.J.H., MD, Puppels, Gerwin J., PhD, Sandilands, Aileen, PhD, Chen, Huijia, PhD, Campbell, Linda E., BSc, Kroboth, Karin, MSc, Watson, Rosemarie, MD, Fallon, Padraic G., PhD, McLean, W. H. Irwin, DSc, FMedSci, Irvine, Alan D., MD, FRCPI
Published in Journal of allergy and clinical immunology (01.04.2012)
Published in Journal of allergy and clinical immunology (01.04.2012)
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Journal Article
Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin
McAleer, Maeve A., MB, MRCP, Pohler, Elizabeth, PhD, Smith, Frances J.D., PhD, Wilson, Neil J., MSc, Cole, Christian, PhD, MacGowan, Stuart, PhD, Koetsier, Jennifer L., BS, Godsel, Lisa M., PhD, Harmon, Robert M., PhD, Gruber, Robert, MD, Crumrine, Debra, BS, Elias, Peter M., MD, McDermott, Michael, FRCPath, Butler, Karina, FRCPI, Broderick, Annemarie, MRCPI, Sarig, Ofer, PhD, Sprecher, Eli, MD, PhD, Green, Kathleen J., PhD, McLean, W.H. Irwin, PhD, DSc, FRS, FRSE, FMedSci, Irvine, Alan D., MD
Published in Journal of allergy and clinical immunology (01.11.2015)
Published in Journal of allergy and clinical immunology (01.11.2015)
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Journal Article
IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis
Hussain, Safia, BSc, Berki, Dorottya M., BSc, Choon, Siew-Eng, MRCP, Burden, A. David, MD, FRCP, Allen, Michael H., PhD, Arostegui, Juan I., MD, PhD, Chaves, Antonio, MD, Duckworth, Michael, Irvine, Alan D., MD, Mockenhaupt, Maja, MD, PhD, Navarini, Alexander A., MD, PhD, Seyger, Marieke M.B., MD, PhD, Soler-Palacin, Pere, MD, PhD, Prins, Christa, MD, Valeyrie-Allanore, Laurence, MD, Vicente, M. Asuncion, MD, Trembath, Richard C., FMedSci, Smith, Catherine H., MD, FRCP, Barker, Jonathan N., MD, FRCP, Capon, Francesca, PhD
Published in Journal of allergy and clinical immunology (01.04.2015)
Published in Journal of allergy and clinical immunology (01.04.2015)
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Journal Article
The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study
Henderson, John, MD, Northstone, Kate, MSc, Lee, Simon P., MSc, Liao, Haihui, MD, Zhao, Yiwei, MD, Pembrey, Marcus, MD, Mukhopadhyay, Somnath, MD, Smith, George Davey, MD, DSc, Palmer, Colin N.A., PhD, McLean, W. H. Irwin, PhD, DSc, Irvine, Alan D., MD
Published in Journal of allergy and clinical immunology (01.04.2008)
Published in Journal of allergy and clinical immunology (01.04.2008)
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Journal Article
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
Saunders, Sean P., PhD, Goh, Christabelle S.M., BSc, Brown, Sara J., MD, Palmer, Colin N.A., PhD, Porter, Rebecca M., PhD, Cole, Christian, PhD, Campbell, Linda E., MSc, Gierlinski, Marek, PhD, Barton, Geoffrey J., PhD, Schneider, Georg, PhD, Balmain, Allan, PhD, Prescott, Alan R., PhD, Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, PhD, Kabesch, Michael, MD, Gieger, Christian, PhD, Lee, Young-Ae, MD, Tavendale, Roger, PhD, Mukhopadhyay, Somnath, MD, Turner, Stephen W., MD, Madhok, Vishnu B., MD, Sullivan, Frank M., MD, Relton, Caroline, PhD, Burn, John, MD, Meggitt, Simon, MD, Smith, Catherine H., MD, Allen, Michael A., PhD, Barker, Jonathan N.W. N., MD, Reynolds, Nick J., MD, Cordell, Heather J., DPhil, Irvine, Alan D., MD, McLean, W.H. Irwin, DSc, Sandilands, Aileen, PhD, Fallon, Padraic G., PhD
Published in Journal of allergy and clinical immunology (01.11.2013)
Published in Journal of allergy and clinical immunology (01.11.2013)
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