STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C
Published in eLife (08.01.2020)
Published in eLife (08.01.2020)
Get full text
Journal Article
EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.
Published in Nature (London) (15.03.2018)
Published in Nature (London) (15.03.2018)
Get full text
Journal Article
Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Morgan, Ann M, Alexe, Gabriela, Schauer, Nathan J, Liu, Xiaoxi, Bird, Gregory H, Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J, Walensky, Loren D, Stegmaier, Kimberly
Published in The Journal of experimental medicine (06.08.2018)
Published in The Journal of experimental medicine (06.08.2018)
Get full text
Journal Article
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53
Yi, Joanna S., Sias-Garcia, Oscar, Nasholm, Nicole, Hu, Xiaoyu, Iniguez, Amanda Balboni, Hall, Matthew D., Davis, Mindy, Guha, Rajarshi, Moreno-Smith, Myrthala, Barbieri, Eveline, Duong, Kevin, Koach, Jessica, Qi, Jun, Bradner, James E., Stegmaier, Kimberly, Weiss, William A., Gustafson, W. Clay
Published in Neoplasia (New York, N.Y.) (01.06.2021)
Published in Neoplasia (New York, N.Y.) (01.06.2021)
Get full text
Journal Article
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly
Published in Nature genetics (01.09.2018)
Published in Nature genetics (01.09.2018)
Get full text
Journal Article
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Young, Richard A., Gray, Nathanael S., Stegmaier, Kimberly
Published in Cancer cell (12.02.2018)
Published in Cancer cell (12.02.2018)
Get full text
Journal Article
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly
Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
Get full text
Journal Article
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles Wm, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly
Published in The Journal of clinical investigation (02.01.2018)
Published in The Journal of clinical investigation (02.01.2018)
Get full text
Journal Article
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
Jiang, Baishan, Jiang, Jie, Kaltheuner, Ines H., Iniguez, Amanda Balboni, Anand, Kanchan, Ferguson, Fleur M., Ficarro, Scott B., Seong, Bo Kyung Alex, Greifenberg, Ann Katrin, Dust, Sofia, Kwiatkowski, Nicholas P., Marto, Jarrod A., Stegmaier, Kimberly, Zhang, Tinghu, Geyer, Matthias, Gray, Nathanael S.
Published in European journal of medicinal chemistry (05.10.2021)
Published in European journal of medicinal chemistry (05.10.2021)
Get full text
Journal Article
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly
Published in Cancer cell (14.06.2021)
Published in Cancer cell (14.06.2021)
Get full text
Journal Article
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen
Published in Nature communications (03.06.2019)
Published in Nature communications (03.06.2019)
Get full text
Journal Article
EWSFLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A, Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R, Toretsky, Jeffrey A, Stegmaier, Kimberly, Lessnick, Stephen L, Chen, Yidong, Bishop, Alexander J. R
Published in Nature (London) (15.03.2018)
Published in Nature (London) (15.03.2018)
Get full text
Journal Article
MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION
Clymer, Jessica, Gionet, Gabrielle, Gonzalez, Elizabeth, Buchan, Graham, Qian, Kenin, Ho, Patricia, O’Rourke, Ryan, Balboni-Iniguez, Amanda, Stegmaier, Kimberley, Ligon, Keith, Piccioni, Federica, Johannessen, Cory, Beroukhim, Rameen, Bandopadhayay, Pratiti
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
Get full text
Journal Article
Author Correction: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
Get full text
Journal Article
Abstract 2062: Selective gene dependencies in MYCN -amplified neuroblastoma include the core transcriptional regulatory circuitry
Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Balboni-Iniguez, Amanda, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 2352: Defining a pediatric cancer dependency map
Dharia, Neekesh V., Malone, Clare, Iniguez, Amanda Balboni, Guenther, Lillian, Chen, Liying, Alexe, Gabriela, Durbin, Adam D., Zimmerman, Mark W., Hong, Andrew, Bandopadhayay, Pratiti, Filbin, Mariella G., Howard, Thomas, Paolella, Brenton, Fung, Iris, Lee, Josephine, Montgomery, Phil, Krill-Burger, John M., Abraham, Brian J., Roth, Jennifer, Root, David E., Young, Richard A., Look, A. Thomas, Beroukhim, Rameen, Boehm, Jesse S., Hahn, William C., Golub, Todd R., Tsherniak, Aviad, Vazquez, Francisca, Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
MEDU-37. NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA
Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth, Gionet, Gabrielle, Qian, Kenin, Clymer, Jessica, Balboni-Iniguez, Amanda, Lam, Fred, Shapira, Ofer, Greenwald, Noah, Rashid, Rumana, Tiv, Hong, Coy, Shannon, Yaffe, Michael, Kieran, Mark, Gokhale, Prafulla, Stegmaier, Kimberley, Santagata, Sandro, Ligon, Keith, Johanneseen, Cory, Beroukhim, Rameen
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
Get full text
Journal Article
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W. Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles W.M, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly
Published in The Journal of clinical investigation (01.01.2018)
Published in The Journal of clinical investigation (01.01.2018)
Get full text
Journal Article
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation
Hahn, William C, Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Amanda Balboni Iniguez, Swanson, Selene K, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, Decaprio, James
Published in bioRxiv (29.10.2019)
Published in bioRxiv (29.10.2019)
Get full text
Paper