Development of GSK's NMR guides – a tool to encourage the use of more sustainable solvents
Gottlieb, Hugo E, Graczyk-Millbrandt, Grazyna, Inglis, Graham GA, Nudelman, Abraham, Perez, David, Qian, Yanqiu, Shuster, Leanna E, Sneddon, Helen F, Upton, Richard J
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2016)
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2016)
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Journal Article
Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza
Macdonald, Simon J. F, Cameron, Rachel, Demaine, Derek A, Fenton, Rob J, Foster, Graham, Gower, David, Hamblin, J. Nicole, Hamilton, Stephanie, Hart, Graham J, Hill, Alan P, Inglis, Graham G. A, Jin, Betty, Jones, Haydn T, McConnell, Darryl B, McKimm-Breschkin, Jennifer, Mills, Gail, Nguyen, Van, Owens, Ian J, Parry, Nigel, Shanahan, Stephen E, Smith, Donna, Watson, Keith G, Wu, Wen-Yang, Tucker, Simon P
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Journal Article
Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen
MACDONALD, Simon J. F, WATSON, Keith G, INGLIS, Graham G. A, JIN, Betty, JONES, Haydn T, MCCONNELL, Darryl B, MASON, Andy M, NGUYEN, Van, OWENS, Ian J, PARRY, Nigel, REECE, Phillip A, SHANAHAN, Stephen E, CAMERON, Rachel, SMITH, Donna, WU, Wen-Yang, TUCKER, Simon P, CHALMERS, David K, DEMAINE, Derek A, FENTON, Rob J, GOWER, David, HAMBLIN, J. Nicole, HAMILTON, Stephanie, HART, Graham J
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
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Journal Article
Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Journal Article
An extremely fast and efficient acylation reaction of alcohols with acid anhydrides in the presence of trimethylsilyl trifluoromethanesulfonate as catalyst
Procopiou, PA, Baugh, SPD, Flack, SS, Inglis, GGA
Published in Chemical communications (Cambridge, England) (1996)
Published in Chemical communications (Cambridge, England) (1996)
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Journal Article
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
Macdonald, Simon J.F, Dowle, Michael D, Harrison, Lee A, Shah, Pritom, Johnson, Martin R, Inglis, Graham G.A, Clarke, Geoffrey D.E, Smith, Robin A, Humphreys, Davina, Molloy, Christopher R, Amour, Augustin, Dixon, Mary, Murkitt, Graham, Godward, Rosalind E, Padfield, Tony, Skarzynski, Tadeusz, Singh, Onkar M.P, Kumar, K.Abhhilash, Fleetwood, Gill, Hodgson, Simon T, Hardy, George W, Finch, Harry
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
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Journal Article
A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology
Macdonald, Simon J. F, Clarke, Geoffrey D. E, Dowle, Michael D, Harrison, Lee A, Hodgson, Simon T, Inglis, Graham G. A, Johnson, Martin R, Shah, Prit, Upton, Richard J, Walls, Steven B
Published in Journal of organic chemistry (09.07.1999)
Published in Journal of organic chemistry (09.07.1999)
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Journal Article
The use of cellulose (chromatography paper) as a cheap, versatile and non-covalent support for organic molecules during multi-step synthesis
Shanahan, SE, Byrne, DD, Inglis, GGA, Alam, M, Macdonald, SJF
Published in Chemical communications (Cambridge, England) (18.10.2002)
Published in Chemical communications (Cambridge, England) (18.10.2002)
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Journal Article
Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
MACDONALD, Simon J. F, DOWLE, Michael D, MOLLOY, Christopher R, DIXON, Mary, MURKITT, Graham, GODWARD, Rosalind E, SKARZYNSKI, Tadeusz, SINGH, Onkar M. P, KUMAR, K. Abhhilash, HODGSON, Simon T, MCDONALD, Edward, HARDY, George W, HARRISON, Lee A, FINCH, Harry, SPOONER, Julie E, SHAH, Pritom, JOHNSON, Martin R, INGLIS, Graham G. A, CLARKE, Geoffrey D. E, BELTON, David J, SMITH, Robin A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Journal Article
Structurally simplified squalestatins : a convenient route to a 6,7-unsubstituted derivative
LESTER, M. G, GIBLIN, G. M. P, INGLIS, G. G. A, PROCOPIOU, P. A, ROSS, B. C, WATSON, N. S
Published in Tetrahedron letters (02.07.1993)
Published in Tetrahedron letters (02.07.1993)
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Journal Article
Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors
Procopiou, Panayiotis A, Draper, Christopher D, Hutson, Julie L, Inglis, Graham G. A, Ross, Barry C, Watson, Nigel S
Published in Journal of medicinal chemistry (12.11.1993)
Published in Journal of medicinal chemistry (12.11.1993)
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Journal Article
The squalestatins: C-3 Decarboxylation studies and rearrangement to the 6,8-dioxabicyclo[3.2.1]octane ring system
Chan, Chuen, Inglis, Graham Ga, Procopiou, Panayiotis A., Ross, Barry C., Srikantha, Anton Rp, Watson, Nigel S.
Published in Tetrahedron letters (17.09.1993)
Published in Tetrahedron letters (17.09.1993)
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Journal Article
Novel squalestatin derivatives arising from reactions at the allylic centre of the C1-side chain
Procopiou, PA, Dymock, BW, Inglis, GGA, Lester, MG, Roberts, AD, Sidebottom, PJ, Spooner, SJ, Srikantha, ARP, Watson, NS
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.01.1998)
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.01.1998)
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Journal Article
THE SQUALESTATINS - CLEAVAGE OF THE BICYCLIC CORE VIA THE NOVEL 6,8-DIOXABICYCLO[3.2.1]OCTANE RING-SYSTEM
PROCOPIOU, PA, BAILEY, EJ, CHAN, C, INGLIS, GGA, LESTER, MG, SRIKANTHA, ARP, SIDEBOTTOM, PJ, WATSON, NS
Published in Journal of the Chemical Society, Perkin Transactions 1 (1995)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1995)
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