Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
Dračínská, Helena, Indra, Radek, Jelínková, Sandra, Černá, Věra, Arlt, Volker, Stiborová, Marie
Published in International journal of molecular sciences (01.08.2021)
Published in International journal of molecular sciences (01.08.2021)
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The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers
Šulc, Miroslav, Indra, Radek, Moserová, Michaela, Schmeiser, Heinz H., Frei, Eva, Arlt, Volker M., Stiborová, Marie
Published in Environmental and molecular mutagenesis (01.04.2016)
Published in Environmental and molecular mutagenesis (01.04.2016)
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Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib
Jáklová, Kateřina, Feglarová, Tereza, Rex, Simona, Heger, Zbyněk, Eckschlager, Tomáš, Hraběta, Jan, Hodek, Petr, Kolárik, Matúš, Indra, Radek
Published in International journal of molecular sciences (20.04.2021)
Published in International journal of molecular sciences (20.04.2021)
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Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
Indra, Radek, Pompach, Petr, Martínek, Václav, Takácsová, Paulína, Vavrová, Katarína, Heger, Zbyněk, Adam, Vojtěch, Eckschlager, Tomáš, Kopečková, Kateřina, Arlt, Volker Manfred, Stiborová, Marie
Published in International journal of molecular sciences (10.07.2019)
Published in International journal of molecular sciences (10.07.2019)
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Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions
Stiborová, Marie, Moserová, Michaela, Černá, Věra, Indra, Radek, Dračínský, Martin, Šulc, Miroslav, Henderson, Colin J., Wolf, C. Roland, Schmeiser, Heinz H., Phillips, David H., Frei, Eva, Arlt, Volker M.
Published in Toxicology (Amsterdam) (06.04.2014)
Published in Toxicology (Amsterdam) (06.04.2014)
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Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity
Indra, Radek, Vavrová, Katarína, Pompach, Petr, Heger, Zbyněk, Hodek, Petr
Published in Biomedicines (28.11.2020)
Published in Biomedicines (28.11.2020)
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver
Indra, Radek, Jelínková, Sandra, Kollárová, Katarína, Zahumenská, Petra, Dvořák, Josef, Dušková, Šárka, Dračínská, Helena
Published in Acta pharmaceutica (Zagreb, Croatia) (01.09.2024)
Published in Acta pharmaceutica (Zagreb, Croatia) (01.09.2024)
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Benzoapyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
Dračínská, Helena, Indra, Radek, Jelínková, Sandra, Černá, Věra, Arlt, Volker Manfred, Stiborová, Marie
Published in International journal of molecular sciences (28.07.2021)
Published in International journal of molecular sciences (28.07.2021)
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NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene
Stiborová, Marie, Indra, Radek, Moserová, Michaela, Frei, Eva, Schmeiser, Heinz H, Kopka, Klaus, Phillips, David H, Arlt, Volker M
Published in Chemical research in toxicology (15.08.2016)
Published in Chemical research in toxicology (15.08.2016)
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Construction of an apoferritin nanocarrier with encapsulated ellipticine and examination of its properties
Indra, Radek, Wilhelm, Marek, Černá, Tereza, Heger, Zbyněk, Dostalová, Simona, Adam, Vojtěch, Eckschlager, Tomáš, Stiborová, Marie
Published in Toxicology letters (20.10.2017)
Published in Toxicology letters (20.10.2017)
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Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b 5 Activity
Indra, Radek, Vavrová, Katarína, Pompach, Petr, Heger, Zbyněk, Hodek, Petr
Published in Biomedicines (28.11.2020)
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Published in Biomedicines (28.11.2020)
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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
Reed, Lindsay, Indra, Radek, Mrizova, Iveta, Moserova, Michaela, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Published in Toxicology and applied pharmacology (01.03.2019)
Published in Toxicology and applied pharmacology (01.03.2019)
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Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice
Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Published in Archives of toxicology (2018)
Published in Archives of toxicology (2018)
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The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells
Willis, Alexandra J., Indra, Radek, Wohak, Laura E., Sozeri, Osman, Feser, Kerstin, Mrizova, Iveta, Phillips, David H., Stiborova, Marie, Arlt, Volker M.
Published in Toxicology (Amsterdam) (01.04.2018)
Published in Toxicology (Amsterdam) (01.04.2018)
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The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
Sborchia, Mateja, De Prez, Eric G., Antoine, Marie-Hélène, Bienfait, Lucie, Indra, Radek, Valbuena, Gabriel, Phillips, David H., Nortier, Joëlle L., Stiborová, Marie, Keun, Hector C., Arlt, Volker M.
Published in Archives of toxicology (01.11.2019)
Published in Archives of toxicology (01.11.2019)
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Modulation of cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADH and cytochrome b5
Indra, Radek, Moserova, Michaela, Volker, Arlt M., Stiborova, Marie
Published in Toxicology letters (10.09.2014)
Published in Toxicology letters (10.09.2014)
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Journal Article
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells
Indra, Radek, Černá, Tereza, Heger, Zbyněk, Hraběta, Jan, Wilhelm, Marek, Dostálová, Simona, Lengálová, Alžběta, Martínková, Markéta, Adam, Vojtěch, Eckschlager, Tomáš, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie
Published in Toxicology (Amsterdam) (01.05.2019)
Published in Toxicology (Amsterdam) (01.05.2019)
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Journal Article
Application of hepatic cytochrome b 5 /P450 reductase null (HBRN) mice to study the role of cytochrome b 5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
Reed, Lindsay, Indra, Radek, Mrizova, Iveta, Moserova, Michaela, Schmeiser, Heinz H, Wolf, C Roland, Henderson, Colin J, Stiborova, Marie, Phillips, David H, Arlt, Volker M
Published in Toxicology and applied pharmacology (01.03.2019)
Published in Toxicology and applied pharmacology (01.03.2019)
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Journal Article
Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
Indra, Radek, Pompach, Petr, Vavrová, Katarína, Jáklová, Kateřina, Heger, Zbyněk, Adam, Vojtěch, Eckschlager, Tomáš, Kopečková, Kateřina, Arlt, Volker Manfred, Stiborová, Marie
Published in Environmental toxicology and pharmacology (01.02.2020)
Published in Environmental toxicology and pharmacology (01.02.2020)
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