Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier-Torres, Lucía, Fortner, Karen A., Iruzubieta, Paula, Delgado, Teresa C., Giddings, Emily, Chen, Youdinghuan, Champagne, Devin, Fernández-Ramos, David, Mestre, Daniela, Gomez-Santos, Beatriz, Varela-Rey, Marta, de Juan, Virginia Gutiérrez, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, García-Monzón, Carmelo, González-Rodríguez, Águeda, Oza, Dhaval, Valença-Pereira, Felipe, Fang, Qian, Crespo, Javier, Aspichueta, Patricia, Tremblay, Frederic, Christensen, Brock C., Anguita, Juan, Martínez-Chantar, María Luz, Rincón, Mercedes
Published in Nature communications (03.07.2020)
Published in Nature communications (03.07.2020)
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Deregulated neddylation in liver fibrosis
Zubiete‐Franco, Imanol, Fernández‐Tussy, Pablo, Barbier‐Torres, Lucía, Simon, Jorge, Fernández‐Ramos, David, Lopitz‐Otsoa, Fernando, Gutiérrez‐de Juan, Virginia, de Davalillo, Sergio López, Duce, Antonio Martín, Iruzubieta, Paula, Taibo, Daniel, Crespo, Javier, Caballeria, Juan, Villa, Erica, Aurrekoetxea, Igor, Aspichueta, Patricia, Varela‐Rey, Marta, Lu, Shelly C, Mato, José M., Beraza, Naiara, Delgado, Teresa C., Martínez‐Chantar, María L
Published in Hepatology (Baltimore, Md.) (01.02.2017)
Published in Hepatology (Baltimore, Md.) (01.02.2017)
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Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin‐1
Barbier‐Torres, Lucía, Beraza, Naiara, Fernández‐Tussy, Pablo, Lopitz‐Otsoa, Fernando, Fernández‐Ramos, David, Zubiete‐Franco, Imanol, Varela‐Rey, Marta, Delgado, Teresa C., Gutiérrez, Virginia, Anguita, Juan, Pares, Albert, Banales, Jesús M., Villa, Erica, Caballería, Juan, Alvarez, Luis, Lu, Shelly C., Mato, Jose M., Martínez‐Chantar, María Luz
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Published in Hepatology (Baltimore, Md.) (01.10.2015)
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Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Simon, Jorge, Nuñez-García, Maitane, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gómez-Santos, Beatriz, Buqué, Xabier, Lopitz-Otsoa, Fernando, Goikoetxea-Usandizaga, Naroa, Serrano-Macia, Marina, Rodriguez-Agudo, Rubén, Bizkarguenaga, Maider, Zubiete-Franco, Imanol, Gutiérrez-de Juan, Virginia, Cabrera, Diana, Alonso, Cristina, Iruzubieta, Paula, Romero-Gomez, Manuel, van Liempd, Sebastiaan, Castro, Azucena, Nogueiras, Ruben, Varela-Rey, Marta, Falcón-Pérez, Juan Manuel, Villa, Erica, Crespo, Javier, Lu, Shelly C., Mato, Jose M., Aspichueta, Patricia, Delgado, Teresa C., Martínez-Chantar, María Luz
Published in Cell metabolism (03.03.2020)
Published in Cell metabolism (03.03.2020)
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
Barbier-Torres, Lucía, Iruzubieta, Paula, Fernández-Ramos, David, Delgado, Teresa C., Taibo, Daniel, Guitiérrez-de-Juan, Virginia, Varela-Rey, Marta, Azkargorta, Mikel, Navasa, Nicolas, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, Simon, Jorge, Lopitz-Otsoa, Fernando, Lachiondo-Ortega, Sofia, Crespo, Javier, Masson, Steven, McCain, Misti Vanette, Villa, Erica, Reeves, Helen, Elortza, Felix, Lucena, Maria Isabel, Hernández-Alvarez, Maria Isabel, Zorzano, Antonio, Andrade, Raúl J., Lu, Shelly C., Mato, José M., Anguita, Juan, Rincón, Mercedes, Martínez-Chantar, María Luz
Published in Nature communications (12.12.2017)
Published in Nature communications (12.12.2017)
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A morphological method for ammonia detection in liver
Gutiérrez-de-Juan, Virginia, López de Davalillo, Sergio, Fernández-Ramos, David, Barbier-Torres, Lucía, Zubiete-Franco, Imanol, Fernández-Tussy, Pablo, Simon, Jorge, Lopitz-Otsoa, Fernando, de Las Heras, Javier, Iruzubieta, Paula, Arias-Loste, María Teresa, Villa, Erica, Crespo, Javier, Andrade, Raúl, Lucena, M Isabel, Varela-Rey, Marta, Lu, Shelly C, Mato, José M, Delgado, Teresa Cardoso, Martínez-Chantar, María-Luz
Published in PloS one (20.03.2017)
Published in PloS one (20.03.2017)
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Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
Fernández-Tussy, Pablo, Rodríguez-Agudo, Rubén, Fernández-Ramos, David, Barbier-Torres, Lucía, Zubiete-Franco, Imanol, Davalillo, Sergio López de, Herraez, Elisa, Goikoetxea-Usandizaga, Naroa, Lachiondo-Ortega, Sofia, Simón, Jorge, Lopitz-Otsoa, Fernando, Juan, Virginia Gutiérrez-de, McCain, Misti V., Perugorria, Maria J., Mabe, Jon, Navasa, Nicolás, Rodrigues, Cecilia M. P., Fabregat, Isabel, Boix, Loreto, Sapena, Victor, Anguita, Juan, Lu, Shelly C., Mato, José M., Banales, Jesus M., Villa, Erica, Reeves, Helen L., Bruix, Jordi, Reig, Maria, Marin, Jose J. G., Delgado, Teresa C., Martínez-Chantar, María L.
Published in Cell death & disease (28.05.2021)
Published in Cell death & disease (28.05.2021)
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Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
Barbier-Torres, Lucía, Delgado, Teresa C, García-Rodríguez, Juan L, Zubiete-Franco, Imanol, Fernández-Ramos, David, Buqué, Xabier, Cano, Ainara, Gutiérrez-de Juan, Virginia, Fernández-Domínguez, Itziar, Lopitz-Otsoa, Fernando, Fernández-Tussy, Pablo, Boix, Loreto, Bruix, Jordi, Villa, Erica, Castro, Azucena, Lu, Shelly C, Aspichueta, Patricia, Xirodimas, Dimitris, Varela-Rey, Marta, Mato, José M, Beraza, Naiara, Martínez-Chantar, María L
Published in Oncotarget (10.02.2015)
Published in Oncotarget (10.02.2015)
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Famotidine increases cellular phospho-tyrosine levels
Zubiete-Franco, Imanol, Tonks, Nicholas K.
Published in Biochemical and biophysical research communications (19.11.2024)
Published in Biochemical and biophysical research communications (19.11.2024)
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Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis
Zubiete-Franco, Imanol, García-Rodríguez, Juan Luis, Martínez-Uña, Maite, Martínez-Lopez, Nuria, Woodhoo, Ashwin, Juan, Virginia Gutiérrez-De, Beraza, Naiara, Lage-Medina, Sergio, Andrade, Fernando, Fernandez, Marta Llarena, Aldámiz-Echevarría, Luis, Fernández-Ramos, David, Falcon-Perez, Juan Manuel, Lopitz-Otsoa, Fernando, Fernandez-Tussy, Pablo, Barbier-Torres, Lucía, Luka, Zigmund, Wagner, Conrad, García-Monzón, Carmelo, Lu, Shelly C, Aspichueta, Patricia, Mato, José María, Martínez-Chantar, María Luz, Varela-Rey, Marta
Published in Journal of hepatology (01.02.2016)
Published in Journal of hepatology (01.02.2016)
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MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Fernández-Ramos, David, Fernández-Tussy, Pablo, Lopitz-Otsoa, Fernando, Gutiérrez-de-Juan, Virginia, Navasa, Nicolás, Barbier-Torres, Lucía, Zubiete-Franco, Imanol, Simón, Jorge, Fernández, Agustín F., Arbelaiz, Ander, Aransay, Ana M., Lavín, José Luis, Beraza, Naiara, Perugorria, María J., Banales, Jesus M., Villa, Erica, Fraga, Mario F., Anguita, Juan, Avila, Matias A., Berasain, Carmen, Iruzibieta, Paula, Crespo, Javier, Lu, Shelly C., Varela-Rey, Marta, Mato, José M., Delgado, Teresa C., Martínez-Chantar, María L.
Published in Cell death & disease (20.09.2018)
Published in Cell death & disease (20.09.2018)
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Targeting hepatic Glutaminase 1 ameliorates Non-Alcoholic Steatohepatitis by restoring Very-Low Density Lipoproteins triglyceride assembly
Simon, Jorge, Nuñez-García, Maitane, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gómez-Santos, Beatriz, Buqué, Xabier, Lopitz-Otsoa, Fernando, Goikoetxea-Usandizaga, Naroa, Serrano-Macia, Marina, Rodriguez-Agudo, Rubén, Bizkarguenaga, Maider, Zubiete-Franco, Imanol, Juan, Virginia Gutiérrez-de, Cabrera, Diana, Alonso, Cristina, Iruzubieta, Paula, Romero-Gomez, Manuel, van Liempd, Sebastiaan, Castro, Azucena, Nogueiras, Ruben, Varela-Rey, Marta, Falcón-Pérez, Juan Manuel, Villa, Erica, Crespo, Javier, Lu, Shelly C., Mato, Jose M., Aspichueta, Patricia, Delgado, Teresa Cardoso, Martínez-Chantar, María Luz
Published in Cell metabolism (21.02.2020)
Published in Cell metabolism (21.02.2020)
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SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
Zubiete-Franco, Imanol, García-Rodríguez, Juan L., Lopitz-Otsoa, Fernando, Serrano-Macia, Marina, Simon, Jorge, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gutiérrez-de-Juan, Virginia, López de Davalillo, Sergio, Carlevaris, Onintza, Beguiristain Gómez, Adolfo, Villa, Erica, Calvisi, Diego, Martín, César, Berra, Edurne, Aspichueta, Patricia, Beraza, Naiara, Varela-Rey, Marta, Ávila, Matias, Rodríguez, Manuel S., Mato, José M., Díaz-Moreno, Irene, Díaz-Quintana, Antonio, Delgado, Teresa C., Martínez-Chantar, María L.
Published in EBioMedicine (01.02.2019)
Published in EBioMedicine (01.02.2019)
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PS-015-Role of methylation-controlled J-protein, endogenous repressor of the mitochondrial respiratory chain, in cholestatic liver disease
Iruzubieta, Paula, Barbier-Torres, Lucía, Goikoetxea, Naroa, Delgado, Teresa Cardoso, Ramos, David Fernández, Varela-Rey, Marta, Juan, Virginia Gutiérrez de, Tussy, Pablo Fernández, Zubiete-Franco, Imanol, Simón, Jorge, Congregado, Daniela Mestre, Otsoa, Fernando Lopitz, Santos, Beatriz Gómez, Buque, Xabier, López-Hoyos, Marcos, Apichueta, Patricia, Mato, José M., Anguita, Juan, Rincón, Mercedes, Crespo, Javier, Martínez-Chantar, María Luz
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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THU-477-Sumoylation/acetylation drives forward oncogenic role of LKB1 in Liver
Otsoa, Fernando Lopitz, Zubiete-FRanco, Imanol, Rodríguez, Juan Luis García, Serrano-Macia, Marina, Simón, Jorge, Tussy, Pablo Fernández, Torres, Lucía Barbier, Fernandez-Ramos, David, de Juan, Virginia Gutiérrez, de Davalillo, Sergio López, Carlevaris, Onintza, Gomez, Adolfo Beguiristain, arrizabalaga, Julio, Calvisi, Diego F, Martin, Cesar, Berra, Edurne, Aspichueta, Patricia, Beraza, Naiara, Varela-Rey, Marta, Avila, Matías A, Rodriguez, Manuel S, Mato, José M., Diaz-Moreno, Irene, Diaz-Quintana, Antonio, Delgado, Teresa Cardoso, Martínez-Chantar, María Luz
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Neddylation, a novel paradigm in liver cancer
Delgado, Teresa Cardoso, Barbier-Torres, Lúcia, Zubiete-Franco, Imanol, Lopitz-Otsoa, Fernando, Varela-Rey, Marta, Fernández-Ramos, David, Martínez-Chantar, María-Luz
Published in Translational gastroenterology and hepatology (01.06.2018)
Published in Translational gastroenterology and hepatology (01.06.2018)
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TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernández-Álvarez, Sara, Gutiérrez-de Juan, Virginia, Zubiete-Franco, Imanol, Barbier-Torres, Lucia, Lahoz, Agustín, Parés, Albert, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C, Mato, José M, Martínez-Chantar, María L, Beraza, Naiara
Published in Laboratory investigation (01.02.2015)
Published in Laboratory investigation (01.02.2015)
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Journal Article
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancerResearch in context
Imanol Zubiete-Franco, Juan L. García-Rodríguez, Fernando Lopitz-Otsoa, Marina Serrano-Macia, Jorge Simon, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Virginia Gutiérrez-de-Juan, Sergio López de Davalillo, Onintza Carlevaris, Adolfo Beguiristain Gómez, Erica Villa, Diego Calvisi, César Martín, Edurne Berra, Patricia Aspichueta, Naiara Beraza, Marta Varela-Rey, Matias Ávila, Manuel S. Rodríguez, José M. Mato, Irene Díaz-Moreno, Antonio Díaz-Quintana, Teresa C. Delgado, María L. Martínez-Chantar
Published in EBioMedicine (01.02.2019)
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Published in EBioMedicine (01.02.2019)
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