Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands
Shibata, Norihito, Miyamoto, Naoki, Nagai, Katsunori, Shimokawa, Kenichiro, Sameshima, Tomoya, Ohoka, Nobumichi, Hattori, Takayuki, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Cancer science (01.08.2017)
Published in Cancer science (01.08.2017)
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In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
Ohoka, Nobumichi, Okuhira, Keiichiro, Ito, Masahiro, Nagai, Katsunori, Shibata, Norihito, Hattori, Takayuki, Ujikawa, Osamu, Shimokawa, Kenichiro, Sano, Osamu, Koyama, Ryokichi, Fujita, Hisashi, Teratani, Mika, Matsumoto, Hirokazu, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in The Journal of biological chemistry (17.03.2017)
Published in The Journal of biological chemistry (17.03.2017)
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Journal Article
Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship
Sakamoto, Kotaro, Sogabe, Satoshi, Kamada, Yusuke, Sakai, Nozomu, Asano, Kouhei, Yoshimatsu, Mie, Ida, Kou, Imaeda, Yasuhiro, Sakamoto, Jun-ichi
Published in Biochemical and biophysical research communications (08.01.2017)
Published in Biochemical and biophysical research communications (08.01.2017)
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Journal Article
Discovery of 3‑Benzyl-1‑(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors
Ito, Masahiro, Tanaka, Toshio, Toita, Akinori, Uchiyama, Noriko, Kokubo, Hironori, Morishita, Nao, Klein, Michael G, Zou, Hua, Murakami, Morio, Kondo, Mitsuyo, Sameshima, Tomoya, Araki, Shinsuke, Endo, Satoshi, Kawamoto, Tomohiro, Morin, Gregg B, Aparicio, Samuel A, Nakanishi, Atsushi, Maezaki, Hironobu, Imaeda, Yasuhiro
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J
Published in Oncotarget (06.04.2018)
Published in Oncotarget (06.04.2018)
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Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein–Protein Interaction Interface
Sameshima, Tomoya, Yamamoto, Takeshi, Sano, Osamu, Sogabe, Satoshi, Igaki, Shigeru, Sakamoto, Kotaro, Ida, Koh, Gotou, Mika, Imaeda, Yasuhiro, Sakamoto, Junichi, Miyahisa, Ikuo
Published in Biochemistry (Easton) (27.02.2018)
Published in Biochemistry (Easton) (27.02.2018)
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Journal Article
Structure-based design of a new series of N-(piperidin-3-yl) pyrimidine-5-carboxamides as renin inhibitors
Imaeda, Yasuhiro, Tawada, Michiko, Suzuki, Shinkichi, Tomimoto, Masaki, Kondo, Mitsuyo, Tarui, Naoki, Sanada, Tsukasa, Kanagawa, Ray, Snell, Gyorgy, Behnke, Craig A., Kubo, Keiji, Kuroita, Takanobu
Published in Bioorganic & medicinal chemistry (15.11.2016)
Published in Bioorganic & medicinal chemistry (15.11.2016)
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Journal Article
Novel approach of fragment-based lead discovery applied to renin inhibitors
Tawada, Michiko, Suzuki, Shinkichi, Imaeda, Yasuhiro, Oki, Hideyuki, Snell, Gyorgy, Behnke, Craig A., Kondo, Mitsuyo, Tarui, Naoki, Tanaka, Toshimasa, Kuroita, Takanobu, Tomimoto, Masaki
Published in Bioorganic & medicinal chemistry (15.11.2016)
Published in Bioorganic & medicinal chemistry (15.11.2016)
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Journal Article
Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor
Imaeda, Yasuhiro, Tokuhara, Hidekazu, Fukase, Yoshiyuki, Kanagawa, Ray, Kajimoto, Yumiko, Kusumoto, Keiji, Kondo, Mitsuyo, Snell, Gyorgy, Behnke, Craig A, Kuroita, Takanobu
Published in ACS medicinal chemistry letters (13.10.2016)
Published in ACS medicinal chemistry letters (13.10.2016)
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Journal Article
Discovery of Imidazo[1,5-c]imidazol-3-ones: Weakly Basic, Orally Active Factor Xa Inhibitors
Imaeda, Yasuhiro, Kuroita, Takanobu, Sakamoto, Hiroki, Kawamoto, Tetsuji, Tobisu, Mamoru, Konishi, Noriko, Hiroe, Katsuhiko, Kawamura, Masaki, Tanaka, Toshimasa, Kubo, Keiji
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
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Journal Article
Experimental study on strength and deformational properties of high strength bolted frictional joints under cyclic tensile loading
Kaneshiro, Shoken, Wani, Masaaki, Araki, Takeru, Uchida, Kenichi, Ogawa, Kei, Imaeda, Yasuhiro
Published in Journal of Structural Engineering, A (2024)
Published in Journal of Structural Engineering, A (2024)
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Journal Article
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands
Shibata, Norihito, Nagai, Katsunori, Morita, Yoko, Ujikawa, Osamu, Ohoka, Nobumichi, Hattori, Takayuki, Koyama, Ryokichi, Sano, Osamu, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Discovery of a B‑Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
Kamada, Yusuke, Sakai, Nozomu, Sogabe, Satoshi, Ida, Koh, Oki, Hideyuki, Sakamoto, Kotaro, Lane, Weston, Snell, Gyorgy, Iida, Motoo, Imaeda, Yasuhiro, Sakamoto, Junichi, Matsui, Junji
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Discovery of selective ATP-competitive eIF4A3 inhibitors
Ito, Masahiro, Iwatani, Misa, Kamada, Yusuke, Sogabe, Satoshi, Nakao, Shoichi, Tanaka, Toshio, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Imaeda, Yasuhiro
Published in Bioorganic & medicinal chemistry (01.04.2017)
Published in Bioorganic & medicinal chemistry (01.04.2017)
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Journal Article
Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins
Tanaka, Yuta, Aikawa, Katsuji, Nishida, Goushi, Homma, Misaki, Sogabe, Satoshi, Igaki, Shigeru, Hayano, Yumi, Sameshima, Tomoya, Miyahisa, Ikuo, Kawamoto, Tomohiro, Tawada, Michiko, Imai, Yumi, Inazuka, Masakazu, Cho, Nobuo, Imaeda, Yasuhiro, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Journal Article
Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors
Ito, Masahiro, Tanaka, Toshio, Cary, Douglas R, Iwatani-Yoshihara, Misa, Kamada, Yusuke, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Imaeda, Yasuhiro
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays
Nakao, Shoichi, Nogami, Masahiro, Iwatani, Misa, Imaeda, Toshihiro, Ito, Masahiro, Tanaka, Toshio, Tawada, Michiko, Endo, Satoshi, Cary, Douglas R., Ohori, Momoko, Imaeda, Yasuhiro, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Araki, Shinsuke
Published in Biochemical and biophysical research communications (12.03.2020)
Published in Biochemical and biophysical research communications (12.03.2020)
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Journal Article
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay
Iwatani-Yoshihara, Misa, Ito, Masahiro, Ishibashi, Yoshihiro, Oki, Hideyuki, Tanaka, Toshio, Morishita, Daisuke, Ito, Takashi, Kimura, Hiromichi, Imaeda, Yasuhiro, Aparicio, Samuel, Nakanishi, Atsushi, Kawamoto, Tomohiro
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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Journal Article
Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design
Yasui, Takeshi, Yamamoto, Takeshi, Sakai, Nozomu, Asano, Kouhei, Takai, Takafumi, Yoshitomi, Yayoi, Davis, Melinda, Takagi, Terufumi, Sakamoto, Kotaro, Sogabe, Satoshi, Kamada, Yusuke, Lane, Weston, Snell, Gyorgy, Iwata, Masashi, Goto, Masayuki, Inooka, Hiroshi, Sakamoto, Jun-ichi, Nakada, Yoshihisa, Imaeda, Yasuhiro
Published in Bioorganic & medicinal chemistry (01.09.2017)
Published in Bioorganic & medicinal chemistry (01.09.2017)
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