STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
Totten, Stephanie P., Im, Young Kyuen, Cepeda Cañedo, Eduardo, Najyb, Ouafa, Nguyen, Alice, Hébert, Steven, Ahn, Ryuhjin, Lewis, Kyle, Lebeau, Benjamin, La Selva, Rachel, Sabourin, Valérie, Martínez, Constanza, Savage, Paul, Kuasne, Hellen, Avizonis, Daina, Santos Martínez, Nancy, Chabot, Catherine, Aguilar-Mahecha, Adriana, Goulet, Marie-Line, Dankner, Matthew, Witcher, Michael, Petrecca, Kevin, Basik, Mark, Pollak, Michael, Topisirovic, Ivan, Lin, Rongtuan, Siegel, Peter M., Kleinman, Claudia L., Park, Morag, St-Pierre, Julie, Ursini-Siegel, Josie
Published in Nature communications (03.06.2021)
Published in Nature communications (03.06.2021)
Get full text
Journal Article
The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
Ahn, Ryuhjin, Sabourin, Valérie, Bolt, Alicia M., Hébert, Steven, Totten, Stephanie, De Jay, Nicolas, Festa, Maria Carolina, Young, Yoon Kow, Im, Young Kyuen, Pawson, Tony, Koromilas, Antonis E., Muller, William J., Mann, Koren K., Kleinman, Claudia L., Ursini-Siegel, Josie
Published in Nature communications (09.03.2017)
Published in Nature communications (09.03.2017)
Get full text
Journal Article
The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression
AHN, Ryuhjin, SABOURIN, Valerie, SIEGEL, Peter M, PAWSON, Tony, URSINI-SIEGEL, Josie, HA, Jacqueline R, CORY, Sean, MARIC, Gordana, YOUNG KYUEN IM, HARDY, W. Rod, HONG ZHAO, PARK, Morag, HALLETT, Michael
Published in Cancer research (Chicago, Ill.) (15.07.2013)
Published in Cancer research (Chicago, Ill.) (15.07.2013)
Get full text
Journal Article
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in Cell metabolism (04.12.2018)
Published in Cell metabolism (04.12.2018)
Get full text
Journal Article
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer
Im, Young Kyuen, Najyb, Ouafa, Gravel, Simon-Pierre, McGuirk, Shawn, Ahn, Ryuhjin, Avizonis, Daina Z, Chénard, Valérie, Sabourin, Valerie, Hudson, Jesse, Pawson, Tony, Topisirovic, Ivan, Pollak, Michael, St-Pierre, Julie, Ursini-Siegel, Josie
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Get full text
Journal Article
Abstract 322: Distinct pools of ShcA coupled tyrosine kinase signaling influences breast tumor heterogeneity and therapeutic responsiveness
Ha, Jacqueline R., Ahn, Ryuhjin, Im, Young Kyuen, Sabourin, Valerie, Smith, Harvey W., Topisirovic, Ivan, Pawson, Tony, Siegel, Peter, Muller, William J., Ursini-Siegel, Josie
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance
Ha, Jacqueline R, Ahn, Ryuhjin, Smith, Harvey W, Sabourin, Valerie, Hébert, Steven, Cepeda Cañedo, Eduardo, Im, Young Kyuen, Kleinman, Claudia L, Muller, William J, Ursini-Siegel, Josie
Published in Molecular cancer research (01.05.2018)
Published in Molecular cancer research (01.05.2018)
Get full text
Journal Article
Translational and HIF-1α-dependent metabolic reprogramming underpin metabolic plasticity and determine responses to kinase inhibitors and biguanides
Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in Cell metabolism (20.09.2018)
Published in Cell metabolism (20.09.2018)
Get full text
Journal Article
Translational and HIF1 -dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides
Hulea, Laura, Simon-Pierre Gravel, Morita, Masahiro, Cargnello, Marie, Oro Uchenunu, Young Kyuen Im, Mclaughlan, Shannon, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaelle, Avizonis, Daina, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in bioRxiv (08.07.2017)
Published in bioRxiv (08.07.2017)
Get full text
Paper