Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A., Nikas, Spyros P., Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W., Benchama, Othman, Stahl, Edward L., Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Liu, Zhi-Jie
Published in Cell (20.02.2020)
Published in Cell (20.02.2020)
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Journal Article
Effects of Cannabinoid Agonists and Antagonists in Rats Discriminating Fentanyl
Alkhelb, Dalal A, Kirunda, Andre, Papanastasiou, Ioannis, Jiang, Shan, Iliopoulos-Tsoutsouvas, Christos, Zvonok, Alexander, Nikas, Spyridon P, Vemuri, Kiran, Makriyannis, Alexandros, Desai, Rajeev I
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Altered sleep during spontaneous cannabinoid withdrawal in male mice
Missig, Galen, Mehta, Niyati, Robbins, James O, Good, Cameron H, Iliopoulos-Tsoutsouvas, Christos, Makriyannis, Alex, Nikas, Spyros P, Bergman, Jack, Carlezon, Jr, William A, Paronis, Carol A
Published in Behavioural pharmacology (01.04.2022)
Published in Behavioural pharmacology (01.04.2022)
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Journal Article
5-Chloro-6-oxo-6H-xantheno[4,3-d]thiazole-2-carbonitrile
Paraskevas, Konstantinos, Iliopoulos-Tsoutsouvas, Christos, Georgiou, Eleftheria A., Kostakis, Ioannis K.
Published in MolBank (01.12.2022)
Published in MolBank (01.12.2022)
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Journal Article
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
Sadybekov, Arman A., Sadybekov, Anastasiia V., Liu, Yongfeng, Iliopoulos-Tsoutsouvas, Christos, Huang, Xi-Ping, Pickett, Julie, Houser, Blake, Patel, Nilkanth, Tran, Ngan K., Tong, Fei, Zvonok, Nikolai, Jain, Manish K., Savych, Olena, Radchenko, Dmytro S., Nikas, Spyros P., Petasis, Nicos A., Moroz, Yurii S., Roth, Bryan L., Makriyannis, Alexandros, Katritch, Vsevolod
Published in Nature (London) (20.01.2022)
Published in Nature (London) (20.01.2022)
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Journal Article
Evidence for spontaneous cannabinoid withdrawal in mice
Paronis, Carol, Iliopoulos-Tsoutsouvas, Christos, Papanastasiou, Ioannis, Makriyannis, Alex, Bergman, Jack, Nikas, Spyros P
Published in Behavioural pharmacology (01.04.2022)
Published in Behavioural pharmacology (01.04.2022)
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Journal Article
Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201
AlKhelb, Dalal, Burke, Emily L, Zvonok, Alexander, Iliopoulos-Tsoutsouvas, Christos, Georgiadis, Markos-Orestis, Jiang, Shan, Ho, Thanh C, Nikas, Spyros P, Makriyannis, Alexandros, Desai, Rajeev I
Published in European journal of pharmacology (05.12.2023)
Published in European journal of pharmacology (05.12.2023)
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Journal Article
Differential Enantiomer-Specific Signaling of Cannabidiol at CB1 Receptors
Bosquez-Berger, Taryn, Wilson, Sierra, Iliopoulos-Tsoutsouvas, Christos, Jiang, Shan, Wager-Miller, Jim, Nikas, Spyros P., Mackie, Ken P., Makriyannis, Alexandros, Straiker, Alex
Published in Molecular pharmacology (01.12.2022)
Published in Molecular pharmacology (01.12.2022)
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Journal Article
Differential Enantiomer-Specific Signaling of Cannabidiol at CB 1 Receptors
Bosquez-Berger, Taryn, Wilson, Sierra, Iliopoulos-Tsoutsouvas, Christos, Jiang, Shan, Wager-Miller, Jim, Nikas, Spyros P, Mackie, Ken P, Makriyannis, Alexandros, Straiker, Alex
Published in Molecular pharmacology (01.12.2022)
Published in Molecular pharmacology (01.12.2022)
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Journal Article
5-Chloro-6-oxo-6IH/I-xantheno[4,3-Id/I]thiazole-2-carbonitrile
Paraskevas, Konstantinos, Iliopoulos-Tsoutsouvas, Christos, Georgiou, Eleftheria A, Kostakis, Ioannis K
Published in MolBank (01.11.2022)
Published in MolBank (01.11.2022)
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Journal Article
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
Jiang, Shan, Iliopoulos-Tsoutsouvas, Christos, Tong, Fei, Brust, Christina A, Keenan, Catherine M, Raghav, Jimit Girish, Hua, Tian, Wu, Simiao, Ho, Jo-Hao, Wu, Yiran, Grim, Travis W, Zvonok, Nikolai, Thakur, Ganesh A, Liu, Zhi-Jie, Sharkey, Keith A, Bohn, Laura M, Nikas, Spyros P, Makriyannis, Alexandros
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists
Papanastasiou, Ioannis P., Georgiadis, Markos-Orestis, Iliopoulos-Tsoutsouvas, Christos, Paronis, Carol A., Brust, Christina A., Tran, Ngan K., Ji, Lipin, Ma, Xiaoyu, Wood, JodiAnne T., Zvonok, Nikolai, Tong, Fei, Bohn, Laura M., Nikas, Spyros P., Makriyannis, Alexandros
Published in European journal of medicinal chemistry (15.02.2022)
Published in European journal of medicinal chemistry (15.02.2022)
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Journal Article
Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations
Brust, Christina A., Swanson, Matthew A., Tsoutsouvas, Christos Iliopoulos, Dimova, Snezana T., Dang, Vuong Q., Stahl, Edward L., Ho, Jo-Hao, Nikas, Spyros P., Makriyannis, Alexandros, Bohn, Laura M.
Published in Receptors (06.08.2024)
Published in Receptors (06.08.2024)
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Journal Article
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G i Complex Structures
Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A, Nikas, Spyros P, Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W, Benchama, Othman, Stahl, Edward L, Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Liu, Zhi-Jie
Published in Cell (20.02.2020)
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Published in Cell (20.02.2020)
Journal Article
Structural basis of Δ 9 -THC analog activity at the Cannabinoid 1 receptor
Gloriam, David, Thorsen, Thor, Kulkarni, Yashraj, Sykes, David, Bøggild, Andreas, Drace, Taner, Hompluem, Pattarin, Iliopoulos-Tsoutsouvas, Christos, Nikas, Spyros, Daver, Henrik, Makriyannis, Alexandros, Nissen, Poul, Gajhede, Michael, Veprintsev, Dmitry, Boesen, Thomas, Kastrup, Jette
Published in Research square (21.05.2024)
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Published in Research square (21.05.2024)
Journal Article
Labelled cannabinergic ligands and related analogs
Iliopoulos Tsoutsouvas, Christos, Nikas, Spyridon P, Ji, Lipin, Kulkarni, Shashank, Makriyannis, Alexandros
Year of Publication 05.09.2023
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Year of Publication 05.09.2023
Patent
Large library docking for cannabinoid-1 receptor agonists with reduced side effects
Tummino, Tia A, Iliopoulos-Tsoutsouvas, Christos, Braz, Joao M, O'Brien, Evan S, Stein, Reed M, Craik, Veronica, Tran, Ngan K, Ganapathy, Suthakar, Liu, Fangyu, Shiimura, Yuki, Tong, Fei, Ho, Thanh C, Radchenko, Dmytro S, Moroz, Yurii S, Rosado, Sian Rodriguez, Bhardwaj, Karnika, Benitez, Jorge, Liu, Yongfeng, Kandasamy, Herthana, Normand, Claire, Semache, Meriem, Sabbagh, Laurent, Glenn, Isabella, Irwin, John J, Kumar, Kaavya Krishna, Makriyannis, Alexandros, Basbaum, Allan I, Shoichet, Brian K
Published in bioRxiv (28.02.2024)
Published in bioRxiv (28.02.2024)
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