Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
Brown, Emily E, DeWeerd, Alexander J, Ildefonso, Cristhian J, Lewin, Alfred S, Ash, John D
Published in Redox biology (01.06.2019)
Published in Redox biology (01.06.2019)
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A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis
Ahmed, Chulbul M, Ildefonso, Cristhian J, Johnson, Howard M, Lewin, Alfred S
Published in PloS one (26.02.2020)
Published in PloS one (26.02.2020)
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Journal Article
Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics
Yaron, Jordan R, Zhang, Liqiang, Guo, Qiuyun, Burgin, Michelle, Schutz, Lauren N, Awo, Enkidia, Wise, Lyn, Krause, Kurt L, Ildefonso, Cristhian J, Kwiecien, Jacek M, Juby, Michael, Rahman, Masmudur M, Chen, Hao, Moyer, Richard W, Alcami, Antonio, McFadden, Grant, Lucas, Alexandra R
Published in Journal of clinical medicine (31.03.2020)
Published in Journal of clinical medicine (31.03.2020)
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Journal Article
Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration
Choudhary, Mayur, Ildefonso, Cristhian J, Lewin, Alfred S, Malek, Goldis
Published in Journal of ocular pharmacology and therapeutics (01.06.2022)
Published in Journal of ocular pharmacology and therapeutics (01.06.2022)
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Journal Article
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis
Ahmed, Chulbul M., Massengill, Michael T., Brown, Emily E., Ildefonso, Cristhian J., Johnson, Howard M., Lewin, Alfred S.
Published in Experimental eye research (01.12.2018)
Published in Experimental eye research (01.12.2018)
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Journal Article
Binocular benefit following monocular subretinal AAV injection in a mouse model of autosomal dominant retinitis pigmentosa (adRP)
Ahmed, Chulbul M., Massengill, Michael T., Ildefonso, Cristhian J., Jalligampala, Archana, Zhu, Ping, Li, Hong, Patel, Anil P., McCall, Maureen A., Lewin, Alfred S.
Published in Vision research (Oxford) (01.05.2023)
Published in Vision research (Oxford) (01.05.2023)
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Journal Article
Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD
Biswal, Manas R, Han, Pingyang, Zhu, Ping, Wang, Zhaoyang, Li, Hong, Ildefonso, Cristhian J, Lewin, Alfred S
Published in Investigative ophthalmology & visual science (01.02.2017)
Published in Investigative ophthalmology & visual science (01.02.2017)
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Journal Article
Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa
Massengill, Michael T, Young, Brianna, Patel, Deep, Jafri, Farwa, Sabogal, Ernesto, Ash, Neil, Li, Hong, Ildefonso, Cristhian J, Lewin, Alfred S
Published in Investigative ophthalmology & visual science (01.11.2018)
Published in Investigative ophthalmology & visual science (01.11.2018)
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Journal Article
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress
Biswal, Manas R., Ahmed, Chulbul M., Ildefonso, Cristhian J., Han, Pingyang, Li, Hong, Jivanji, Hiral, Mao, Haoyu, Lewin, Alfred S.
Published in Experimental eye research (01.11.2015)
Published in Experimental eye research (01.11.2015)
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Journal Article
Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders
Massengill, Michael T, Young, Brianna M, Lewin, Alfred S, Ildefonso, Cristhian J
Published in Methods in molecular biology (Clifton, N.J.) (2019)
Published in Methods in molecular biology (Clifton, N.J.) (2019)
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Journal Article
Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide
Ildefonso, Cristhian J, Jaime, Henrique, Brown, Emily E, Iwata, Ryo L, Ahmed, Chulbul M, Massengill, Michael T, Biswal, Manas R, Boye, Shannon E, Hauswirth, William W, Ash, John D, Li, Qiuhong, Lewin, Alfred S
Published in Investigative ophthalmology & visual science (01.02.2016)
Published in Investigative ophthalmology & visual science (01.02.2016)
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Journal Article
Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways
Akinfenwa, Patricia Y., Bond, Wesley S., Ildefonso, Cristhian J., Hurwitz, Mary Y., Hurwitz, Richard L.
Published in The Journal of biological chemistry (01.09.2017)
Published in The Journal of biological chemistry (01.09.2017)
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