Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT
Miyauchi, Yuu, Kurita, Ayumi, Yamashita, Ryohei, Takamatsu, Tomoyuki, Ikushiro, Shin’ichi, Mackenzie, Peter I., Tanaka, Yoshitaka, Ishii, Yuji
Published in Biochemical and biophysical research communications (30.04.2020)
Published in Biochemical and biophysical research communications (30.04.2020)
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Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants
Ishii, Yuji, Koba, Hiroki, Kinoshita, Kousuke, Oizaki, Toshiya, Iwamoto, Yuki, Takeda, Shuso, Miyauchi, Yuu, Nishimura, Yoshio, Egoshi, Natsuki, Taura, Futoshi, Morimoto, Satoshi, Ikushiro, Shin'ichi, Nagata, Kiyoshi, Yamazoe, Yasushi, Mackenzie, Peter I, Yamada, Hideyuki
Published in Drug metabolism and disposition (01.02.2014)
Published in Drug metabolism and disposition (01.02.2014)
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Comparison of metabolism and biological properties among positional isomers of quercetin glucuronide in LPS- and RANKL-challenged RAW264.7 cells
Nishikawa, Miyu, Kada, Yuriko, Kimata, Mirai, Sakaki, Toshiyuki, Ikushiro, Shinichi
Published in Bioscience, biotechnology, and biochemistry (23.11.2022)
Published in Bioscience, biotechnology, and biochemistry (23.11.2022)
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Effect of Wheat-Derived Arabinoxylan on the Gut Microbiota Composition and Colonic Regulatory T Cells
Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro
Published in Molecules (Basel, Switzerland) (30.03.2023)
Published in Molecules (Basel, Switzerland) (30.03.2023)
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Beneficial Effects of Dietary Fiber in Young Barley Leaf on Gut Microbiota and Immunity in Mice
Chudan, Seita, Kurakawa, Takuto, Nishikawa, Miyu, Nagai, Yoshinori, Tabuchi, Yoshiaki, Ikushiro, Shinichi, Furusawa, Yukihiro
Published in Molecules (Basel, Switzerland) (01.04.2024)
Published in Molecules (Basel, Switzerland) (01.04.2024)
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Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D
Takita, Teisuke, Sakuma, Hiro, Ohashi, Ren, Nilouyal, Somaye, Nemoto, Sho, Wada, Moeka, Yogo, Yuya, Yasuda, Kaori, Ikushiro, Shinichi, Sakaki, Toshiyuki, Yasukawa, Kiyoshi
Published in Bioscience, biotechnology, and biochemistry (21.03.2022)
Published in Bioscience, biotechnology, and biochemistry (21.03.2022)
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Regioselective Glucuronidation of Flavones at C5, C7, and C4′ Positions in Human Liver and Intestinal Microsomes: Comparison among Apigenin, Acacetin, and Genkwanin
Hanioka, Nobumitsu, Tanaka-Kagawa, Toshiko, Mori, Yoko, Ikushiro, Shinichi, Jinno, Hideto, Ohkawara, Susumu, Isobe, Takashi
Published in Biological & pharmaceutical bulletin (01.08.2022)
Published in Biological & pharmaceutical bulletin (01.08.2022)
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Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation
Kurita, Ayumi, Miyauchi, Yuu, Ikushiro, Shin'ichi, Mackenzie, Peter I, Yamada, Hideyuki, Ishii, Yuji
Published in The Journal of pharmacology and experimental therapeutics (01.05.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2017)
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Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Kise, Satoko, Iijima, Ayano, Nagao, Chika, Okada, Tadashi, Nishikawa, Miyu, Ikushiro, Shinichi, Nakanishi, Tomoko, Sato, Shigeto, Yasuda, Kaori, Sakaki, Toshiyuki
Published in Scientific reports (28.10.2023)
Published in Scientific reports (28.10.2023)
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Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice
Ishibashi, Riko, Furusawa, Yukihiro, Honda, Hiroe, Watanabe, Yasuharu, Fujisaka, Shiho, Nishikawa, Miyu, Ikushiro, Shinichi, Kurihara, Shin, Tabuchi, Yoshiaki, Tobe, Kazuyuki, Takatsu, Kiyoshi, Nagai, Yoshinori
Published in Molecular nutrition & food research (01.05.2022)
Published in Molecular nutrition & food research (01.05.2022)
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Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis
Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro
Published in Food & function (21.02.2023)
Published in Food & function (21.02.2023)
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Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator
Mano, Hiroki, Takano, Masashi, Ikushiro, Shinichi, Kittaka, Atsushi, Sakaki, Toshiyuki
Published in Biochemical and biophysical research communications (28.10.2018)
Published in Biochemical and biophysical research communications (28.10.2018)
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Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique
Mano, Hiroki, Ikushiro, Shinichi, Saito, Nozomi, Kittaka, Atsushi, Sakaki, Toshiyuki
Published in The Journal of steroid biochemistry and molecular biology (01.04.2018)
Published in The Journal of steroid biochemistry and molecular biology (01.04.2018)
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Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats
Nishikawa, Miyu, Murose, Naruhiro, Mano, Hiroki, Yasuda, Kaori, Isogai, Yasuhiro, Kittaka, Atsushi, Takano, Masashi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Published in Scientific reports (22.07.2022)
Published in Scientific reports (22.07.2022)
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Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin
Tanaka, Seiya, Oyama, Manami, Nishikawa, Miyu, Ikushiro, Shinichi, Hara, Hiroshi
Published in Bioscience, biotechnology, and biochemistry (02.12.2018)
Published in Bioscience, biotechnology, and biochemistry (02.12.2018)
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Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina
Sato, Yoshinori, Dong, Wenjing, Nakamura, Tatsuro, Mizoguchi, Naohiro, Nawaji, Tasuku, Nishikawa, Miyu, Onaga, Takenori, Ikushiro, Shinichi, Kobayashi, Makoto, Teraoka, Hiroki
Published in International journal of molecular sciences (16.02.2023)
Published in International journal of molecular sciences (16.02.2023)
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Journal Article
Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery
Yasuda, Kaori, Nishikawa, Miyu, Mano, Hiroki, Takano, Masashi, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Published in International journal of molecular sciences (31.10.2021)
Published in International journal of molecular sciences (31.10.2021)
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Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system
Yasuda, Kaori, Nishikawa, Miyu, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Yamaguchi, Mana, Okon, Risa, Nakagawa, Kimie, Tsugawa, Naoko, Okano, Toshio, Kawagoe, Fumihiro, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions
Nishikawa, Miyu, Yasuda, Kaori, Takamatsu, Masashi, Abe, Keisuke, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Nakagawa, Kimie, Tsugawa, Naoko, Hirota, Yoshihisa, Horie, Tetsuhiro, Hinoi, Eiichi, Okano, Toshio, Ikushiro, Shinichi, Sakaki, Toshiyuki
Published in Scientific reports (30.03.2020)
Published in Scientific reports (30.03.2020)
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