A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J, Doolittle, Madison L, Zhang, Xu, LeBrasseur, Nathan K, Pignolo, Robert J, Robbins, Paul D, Niedernhofer, Laura J, Ikeno, Yuji, Jurk, Diana, Passos, João F, Hickson, LaTonya J, Xue, Ailing, Monroe, David G, Tchkonia, Tamara, Kirkland, James L, Farr, Joshua N, Khosla, Sundeep
Published in Nature communications (16.08.2022)
Published in Nature communications (16.08.2022)
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Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
Mitchell, Sarah J., Bernier, Michel, Mattison, Julie A., Aon, Miguel A., Kaiser, Tamzin A., Anson, R. Michael, Ikeno, Yuji, Anderson, Rozalyn M., Ingram, Donald K., de Cabo, Rafael
Published in Cell metabolism (08.01.2019)
Published in Cell metabolism (08.01.2019)
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Laberge, Remi-Martin, Sun, Yu, Orjalo, Arturo V, Patil, Christopher K, Freund, Adam, Zhou, Lili, Curran, Samuel C, Davalos, Albert R, Wilson-Edell, Kathleen A, Liu, Su, Limbad, Chandani, Demaria, Marco, Li, Patrick, Hubbard, Gene B, Ikeno, Yuji, Javors, Martin, Desprez, Pierre-Yves, Benz, Christopher C, Kapahi, Pankaj, Nelson, Peter S, Campisi, Judith
Published in Nature cell biology (01.08.2015)
Published in Nature cell biology (01.08.2015)
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Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
Mao, Kai, Quipildor, Gabriela Farias, Tabrizian, Tahmineh, Novaj, Ardijana, Guan, Fangxia, Walters, Ryan O, Delahaye, Fabien, Hubbard, Gene B, Ikeno, Yuji, Ejima, Keisuke, Li, Peng, Allison, David B, Salimi-Moosavi, Hossein, Beltran, Pedro J, Cohen, Pinchas, Barzilai, Nir, Huffman, Derek M
Published in Nature communications (19.06.2018)
Published in Nature communications (19.06.2018)
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Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Hofmann, Jeffrey W., Zhao, Xiaoai, De Cecco, Marco, Peterson, Abigail L., Pagliaroli, Luca, Manivannan, Jayameenakshi, Hubbard, Gene B., Ikeno, Yuji, Zhang, Yongqing, Feng, Bin, Li, Xiaxi, Serre, Thomas, Qi, Wenbo, Van Remmen, Holly, Miller, Richard A., Bath, Kevin G., de Cabo, Rafael, Xu, Haiyan, Neretti, Nicola, Sedivy, John M.
Published in Cell (29.01.2015)
Published in Cell (29.01.2015)
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A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence
Zhang, Yiqiang, Unnikrishnan, Archana, Deepa, Sathyaseelan S., Liu, Yuhong, Li, Yan, Ikeno, Yuji, Sosnowska, Danuta, Van Remmen, Holly, Richardson, Arlan
Published in Redox biology (01.04.2017)
Published in Redox biology (01.04.2017)
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep
Published in The Journal of clinical investigation (17.04.2023)
Published in The Journal of clinical investigation (17.04.2023)
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Sexual dimorphic impact of adult‐onset somatopause on life span and age‐induced osteoarthritis
Poudel, Sher Bahadur, Dixit, Manisha, Yildirim, Gozde, Cordoba‐Chacon, Jose, Gahete, Manuel D., Yuji, Ikeno, Kirsch, Thorsten, Kineman, Rhonda D., Yakar, Shoshana
Published in Aging cell (01.08.2021)
Published in Aging cell (01.08.2021)
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Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?
Bokov, Alex F, Garg, Neha, Ikeno, Yuji, Thakur, Sachin, Musi, Nicolas, DeFronzo, Ralph A, Zhang, Ning, Erickson, Rebecca C, Gelfond, Jon, Hubbard, Gene B, Adamo, Martin L, Richardson, Arlan
Published in PloS one (23.11.2011)
Published in PloS one (23.11.2011)
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The paradoxical role of thioredoxin on oxidative stress and aging
Cunningham, Geneva M., Roman, Madeline G., Flores, Lisa C., Hubbard, Gene B., Salmon, Adam B., Zhang, Yiqiang, Gelfond, Jonathan, Ikeno, Yuji
Published in Archives of biochemistry and biophysics (15.06.2015)
Published in Archives of biochemistry and biophysics (15.06.2015)
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Measures of Healthspan as Indices of Aging in Mice-A Recommendation
Richardson, Arlan, Fischer, Kathleen E, Speakman, John R, de Cabo, Rafael, Mitchell, Sarah J, Peterson, Charlotte A, Rabinovitch, Peter, Chiao, Ying A, Taffet, George, Miller, Richard A, Rentería, René C, Bower, James, Ingram, Donald K, Ladiges, Warren C, Ikeno, Yuji, Sierra, Felipe, Austad, Steven N
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2016)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2016)
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IGF‐1 Regulates Vertebral Bone Aging Through Sex‐Specific and Time‐Dependent Mechanisms
Ashpole, Nicole M, Herron, Jacquelyn C, Mitschelen, Matthew C, Farley, Julie A, Logan, Sreemathi, Yan, Han, Ungvari, Zoltan, Hodges, Erik L, Csiszar, Anna, Ikeno, Yuji, Humphrey, Mary Beth, Sonntag, William E
Published in Journal of bone and mineral research (01.02.2016)
Published in Journal of bone and mineral research (01.02.2016)
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Author Correction: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Laberge, Remi-Martin, Sun, Yu, Orjalo, Arturo V, Patil, Christopher K, Freund, Adam, Zhou, Lili, Curran, Samuel C, Davalos, Albert R, Wilson-Edell, Kathleen A, Liu, Su, Limbad, Chandani, Demaria, Marco, Li, Patrick, Hubbard, Gene B, Ikeno, Yuji, Javors, Martin, Desprez, Pierre-Yves, Benz, Christopher C, Kapahi, Pankaj, Nelson, Peter S, Campisi, Judith
Published in Nature cell biology (01.05.2021)
Published in Nature cell biology (01.05.2021)
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Reductions in serum IGF‐1 during aging impair health span
Gong, Zhenwei, Kennedy, Oran, Sun, Hui, Wu, YingJie, Williams, Garry A, Klein, Laura, Cardoso, Luis, Matheny, Ronald W., Hubbard, Gene B., Ikeno, Yuji, Farrar, Roger P., Schaffler, Mitchell B, Adamo, Martin L, Muzumdar, Radhika H, Yakar, Shoshana
Published in Aging cell (01.06.2014)
Published in Aging cell (01.06.2014)
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Lifespan extension in genetically modified mice
Ladiges, Warren, Van Remmen, Holly, Strong, Randy, Ikeno, Yuji, Treuting, Piper, Rabinovitch, Peter, Richardson, Arlan
Published in Aging cell (01.08.2009)
Published in Aging cell (01.08.2009)
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Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice
List, Edward O, Berryman, Darlene E, Ikeno, Yuji, Hubbard, Gene B, Funk, Kevin, Comisford, Ross, Young, Jonathan A, Stout, Michael B, Tchkonia, Tamar, Masternak, Michal M, Bartke, Andrzej, Kirkland, James L, Miller, Richard A, Kopchick, John J
Published in Aging (Albany, NY.) (01.07.2015)
Published in Aging (Albany, NY.) (01.07.2015)
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Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress
Pérez, Viviana I., Lew, Christie M., Cortez, Lisa A., Webb, Celeste R., Rodriguez, Marisela, Liu, Yuhong, Qi, Wenbo, Li, Yan, Chaudhuri, Asish, Van Remmen, Holly, Richardson, Arlan, Ikeno, Yuji
Published in Free radical biology & medicine (01.03.2008)
Published in Free radical biology & medicine (01.03.2008)
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Long-term IGF-I exposure decreases autophagy and cell viability
Bitto, Alessandro, Lerner, Chad, Torres, Claudio, Roell, Michaela, Malaguti, Marco, Perez, Viviana, Lorenzini, Antonello, Hrelia, Silvana, Ikeno, Yuji, Matzko, Michelle Elizabeth, McCarter, Roger, Sell, Christian
Published in PloS one (07.09.2010)
Published in PloS one (07.09.2010)
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San Antonio Nathan Shock Center: your one-stop shop for aging research
Salmon, Adam B., Nelson, James F., Gelfond, Jonathan A. L., Javors, Martin, Ginsburg, Brett, Lopez-Cruzan, Marisa, Galvan, Veronica, Fernandez, Elizabeth, Musi, Nicolas, Ikeno, Yuji, Hubbard, Gene, Lechleiter, James, Hornsby, Peter J., Strong, Randy
Published in GeroScience (01.10.2021)
Published in GeroScience (01.10.2021)
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The implications of mitochondria in doxorubicin treatment of cancer in the context of traditional and modern medicine
da Cunha Menezes Souza, Leonardo, Chen, Meng, Ikeno, Yuji, Salvadori, Daisy Maria Fávero, Bai, Yidong
Published in Traditional medicine and modern medicine (01.12.2020)
Published in Traditional medicine and modern medicine (01.12.2020)
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