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Yamazawa, Toshiko, Kobayashi, Takuya, Kurebayashi, Nagomi, Konishi, Masato, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U., Nishino, Ichizo, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kagechika, Hiroyuki, Uryash, Arkady, Adams, Jose, Lopez, Jose R., Liu, Xiaochen, Diggle, Christine, Allen, Paul D., Kakizawa, Sho, Ikeda, Keigo, Lin, Bangzhong, Ikemi, Yui, Nunomura, Kazuto, Nakagawa, Shinsaku, Sakurai, Takashi, Murayama, Takashi
Published in Nature communications (13.07.2021)
Published in Nature communications (13.07.2021)
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Journal Article
Development of a water-soluble ryanodine receptor 1 inhibitor
Ishida, Ryosuke, Mori, Shuichi, Murayama, Takashi, Nakamichi, Ayaka, Chai, Xikun, Kurebayashi, Nagomi, Iinuma, Hiroto, Kagechika, Hiroyuki
Published in Bioorganic & medicinal chemistry (15.11.2022)
Published in Bioorganic & medicinal chemistry (15.11.2022)
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Journal Article
A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
Ishida, Ryosuke, Kurebayashi, Nagomi, Iinuma, Hiroto, Zeng, Xi, Mori, Shuichi, Kodama, Masami, Murayama, Takashi, Masuno, Hiroyuki, Takeda, Fumi, Kawahata, Masatoshi, Tanatani, Aya, Miura, Aya, Nishio, Hajime, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (15.12.2023)
Published in European journal of medicinal chemistry (15.12.2023)
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Journal Article
Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay
Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Ishigami-Yuasa, Mari, Murayama, Takashi, Nishijima, Yoshiaki, Sakurai, Akiko, Arai, Ryota, Kurebayashi, Nagomi, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke
Yamazawa, Toshiko, Kobayashi, Takuya, Kurebayashi, Nagomi, Konishi, Masato, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U, Nishino, Ichizo, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kagechika, Hiroyuki, Uryas, Arkady, Adams, Jose, Lopez, Jose R, Liu, Xiaochen, Diggle, Christine, Allen, Paul D, Kakizawa, Sho, Ikeda, Keigo, Lin, Bangzhong, Ikemi, Yui, Nunomura, Kazuto, Nakagawa, Shinsaku, Sakurai, Takashi, Murayama, Takashi
Published in bioRxiv (06.02.2021)
Published in bioRxiv (06.02.2021)
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Paper
Structure Development of Oxolinic Acid, a Novel Inhibitor of Type 1 Ryanodine Receptor (RyR1) Ca2+ Release Channel
Nishijima, Yoshiaki, Murayama, Takashi, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kurebayashi, Nagomi, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
TYPE 2 RYANODINE RECEPTOR ACTIVITY INHIBITOR
MURAYAMA, Takashi, MORI, Shuichi, KUNIHIRO, Nagomi Kurebayashi, IINUMA, Hiroto, YUASA, Mari, KAGECHIKA, Hiroyuki
Year of Publication 19.08.2021
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Year of Publication 19.08.2021
Patent
CPVTモデルマウスに対するRyR2特異的阻害薬の効果
呉林, なごみ, 村山, 尚, 石井, 光一郎, 小西, 真人, 杉原, 匡美, 森, 修一, 飯沼, 大翔, 石上-湯浅, 磨里, 村越, 伸行, 影近, 弘之, 櫻井, 隆
Published in 日本薬理学会年会要旨集 (2021)
Published in 日本薬理学会年会要旨集 (2021)
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Journal Article
Structural development of a type-1 ryanodine receptor (RyR1) Ca 2+ -release channel inhibitor guided by endoplasmic reticulum Ca 2+ assay
Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Ishigami-Yuasa, Mari, Murayama, Takashi, Nishijima, Yoshiaki, Sakurai, Akiko, Arai, Ryota, Kurebayashi, Nagomi, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (29.06.2019)
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Published in European journal of medicinal chemistry (29.06.2019)
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新規1型リアノジン受容体阻害薬オキソリン酸の構造展開
村山, 尚, 西島, 由朗, 森, 修一, 飯沼, 大翔, 間中, 紀暁, 呉林, なごみ, 湯浅(石上), 磨里, 影近, 弘之, 櫻井, 隆
Published in 日本薬理学会年会要旨集 (2019)
Published in 日本薬理学会年会要旨集 (2019)
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Journal Article
TYPE 2 RYANODINE RECEPTOR ACTIVITY INHIBITOR
MURAYAMA, Takashi, MORI, Shuichi, KUNIHIRO, Nagomi Kurebayashi, IINUMA, Hiroto, YUASA, Mari, KAGECHIKA, Hiroyuki
Year of Publication 01.05.2024
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Year of Publication 01.05.2024
Patent
TYPE 2 RYANODINE RECEPTOR ACTIVITY INHIBITOR
MURAYAMA, Takashi, MORI, Shuichi, KUNIHIRO, Nagomi Kurebayashi, IINUMA, Hiroto, YUASA, Mari, KAGECHIKA, Hiroyuki
Year of Publication 18.05.2023
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Year of Publication 18.05.2023
Patent
Effects of RyR2 specific inhibitors on arrhythmia in CPVT model mice
Kurebayashi, Nagomi, Murayama, Takashi, Ishii, Koichiro, Konishi, Masato, Sugihara, Masami, Mori, Shuichi, Iinuma, Hiroto, Ishigami-Yuasa, Mari, Murakoshi, Nobuyuki, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2021)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2021)
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Journal Article
TYPE 2 RYANODINE RECEPTOR ACTIVITY INHIBITOR
MURAYAMA, Takashi, MORI, Shuichi, KUNIHIRO, Nagomi Kurebayashi, IINUMA, Hiroto, YUASA, Mari, KAGECHIKA, Hiroyuki
Year of Publication 21.12.2022
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Year of Publication 21.12.2022
Patent
Structure development of oxolinic acid, a novel inhibitor of type 1 ryanodine receptor
Murayama, Takashi, Nishijima, Yoshiaki, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kurebayashi, Nagomi, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
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Journal Article