The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist
Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
Iglarz, Marc, Binkert, Christoph, Morrison, Keith, Fischli, Walter, Gatfield, John, Treiber, Alexander, Weller, Thomas, Bolli, Martin H, Boss, Christoph, Buchmann, Stephan, Capeleto, Bruno, Hess, Patrick, Qiu, Changbin, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension
Iglarz, Marc, Bossu, Alexandre, Wanner, Daniel, Bortolamiol, Céline, Rey, Markus, Hess, Patrick, Clozel, Martine
Published in Life sciences (1973) (24.11.2014)
Published in Life sciences (1973) (24.11.2014)
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Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice
Houde, Martin, Desbiens, Louisane, Schwertani, Adel, Pejler, Gunnar, Iglarz, Marc, D'Orléans-Juste, Pedro
Published in Life sciences (1973) (15.08.2016)
Published in Life sciences (1973) (15.08.2016)
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Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
AMIRI, Farhad, VIRDIS, Agostino, FRITSCH NEVES, Mario, IGLARZ, Marc, SEIDAH, Nabil G, TOUYZ, Rhian M, REUDELHUBER, Timothy L, SCHIFFRIN, Ernesto L
Published in Circulation (New York, N.Y.) (12.10.2004)
Published in Circulation (New York, N.Y.) (12.10.2004)
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Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats
Mamazhakypov, Argen, Weiß, Astrid, Zukunft, Sven, Sydykov, Akylbek, Kojonazarov, Baktybek, Wilhelm, Jochen, Vroom, Christina, Petrovic, Aleksandar, Kosanovic, Djuro, Weissmann, Norbert, Seeger, Werner, Fleming, Ingrid, Iglarz, Marc, Grimminger, Friedrich, Ghofrani, Hossein A., Pullamsetti, Soni S., Schermuly, Ralph T.
Published in Pulmonary circulation (01.10.2020)
Published in Pulmonary circulation (01.10.2020)
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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension
Iglarz, Marc, Landskroner, Kyle, Bauer, Yasmina, Vercauteren, Magali, Rey, Markus, Renault, Berengère, Studer, Rolf, Vezzali, Enrico, Freti, Diego, Hadana, Hakim, Schläpfer, Manuela, Cattaneo, Christophe, Bortolamiol, Céline, Weber, Edgar, Whitby, Brian R, Delahaye, Stéphane, Wanner, Daniel, Steiner, Pauline, Nayler, Oliver, Hess, Patrick, Clozel, Martine
Published in Journal of cardiovascular pharmacology (01.11.2015)
Published in Journal of cardiovascular pharmacology (01.11.2015)
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The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation
Iglarz, Marc, Schulz, Eberhard, Münzel, Thomas, Daiber, Andreas, Jansen, Thomas, Helmstädter, Johanna, Kröller-Schön, Swenja, Kashani, Fatemeh, Roohani, Siyer, Hausding, Michael, Oelze, Matthias, Steven, Sebastian, Baum, Christine
Published in Oxidative medicine and cellular longevity (01.01.2018)
Published in Oxidative medicine and cellular longevity (01.01.2018)
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Dual ETA/ETB blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension
Nadeau, Valerie, Potus, Francois, Boucherat, Olivier, Paradis, Renee, Tremblay, Eve, Iglarz, Marc, Paulin, Roxane, Bonnet, Sebastien, Provencher, Steeve
Published in Pulmonary circulation (01.01.2018)
Published in Pulmonary circulation (01.01.2018)
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Journal Article
Identification of a Novel Role for Endothelins within the Oviduct
Jeoung, Myoungkun, Lee, Sungeun, Hawng, Hee-kyung, Cheon, Yong-Pil, Jeong, Youn Kyung, Gye, Myung Chan, Iglarz, Marc, Ko, CheMyong, Bridges, Phillip J
Published in Endocrinology (Philadelphia) (01.06.2010)
Published in Endocrinology (Philadelphia) (01.06.2010)
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Endothelin-2 induces oviductal contraction via endothelin receptor subtype A in rats
Al-Alem, Linah, Bridges, Phillip J, Su, Wen, Gong, Ming C, Iglarz, Marc, Ko, CheMyong
Published in Journal of endocrinology (01.06.2007)
Published in Journal of endocrinology (01.06.2007)
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Preproendothelin-1 Gene Polymorphism Is Related to a Change in Vascular Reactivity in the Human Mammary Artery In Vitro
Iglarz, Marc, Benessiano, Joëlle, Philip, Ivan, Vuillaumier-Barrot, Sandrine, Lasocki, Sigismond, Hvass, Ulrich, Durand, Geneviève, Desmonts, Jean-Marie, Lévy, Bernard I, Henrion, Daniel
Published in Hypertension (Dallas, Tex. 1979) (01.02.2002)
Published in Hypertension (Dallas, Tex. 1979) (01.02.2002)
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Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention
Vercauteren, Magali, Trensz, Frederic, Pasquali, Anne, Cattaneo, Christophe, Strasser, Daniel S, Hess, Patrick, Iglarz, Marc, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.05.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2017)
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Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery
Morrison, Keith, Haag, Franck, Ernst, Roland, Iglarz, Marc, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction
Valero-Munoz, Maria, Li, Shanpeng, Wilson, Richard M, Boldbaatar, Batbold, Iglarz, Marc, Sam, Flora
Published in Circulation. Heart failure (01.11.2016)
Published in Circulation. Heart failure (01.11.2016)
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Journal Article
The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist
Cipriani, Paola, Di Benedetto, Paola, Ruscitti, Piero, Capece, Daria, Zazzeroni, Francesca, Liakouli, Vasiliki, Pantano, Ilenia, Berardicurti, Onorina, Carubbi, Francesco, Pecetti, Gianluca, Turricchia, Stefano, Alesse, Edoardo, Iglarz, Marc, Giacomelli, Roberto
Published in Journal of rheumatology (01.10.2015)
Published in Journal of rheumatology (01.10.2015)
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