Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
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Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity
Lin, Amy H, Burrascano, Cindy, Pettersson, Par L, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J
Published in Journal of virology (01.09.2014)
Published in Journal of virology (01.09.2014)
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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
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Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids
Burnett, Ryan, Ibañez, Carlos E, Pettersson, Pär L, Chen, Ching-I, Parab, Shraddha, Huang, Tiffany, Robbins, Joan, Bankiewicz, Krystof, Aghi, Manish, Logg, Christopher, Kasahara, Noriyuki, Pertschuk, Dan, Gruber, Harry E, Jolly, Douglas J
Published in Molecular therapy. Methods & clinical development (01.01.2014)
Published in Molecular therapy. Methods & clinical development (01.01.2014)
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Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
Ostertag, Derek, Amundson, Karin K, Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, Galvão da Silva, Ana Paula, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
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Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types
Twitty, Chris G, Diago, Oscar R, Hogan, Daniel J, Burrascano, Cindy, Ibanez, Carlos E, Jolly, Douglas J, Ostertag, Derek
Published in Human gene therapy. Part B. Methods (01.02.2016)
Published in Human gene therapy. Part B. Methods (01.02.2016)
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Journal Article
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy. Oncolytics (30.03.2018)
Published in Molecular therapy. Oncolytics (30.03.2018)
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Generation of Retroviral Packaging and Producer Cell Lines for Large-Scale Vector Production and Clinical Application: Improved Safety and High Titer
Sheridan, Philip L., Bodner, Mordechai, Lynn, Andrea, Phuong, Trung K., DePolo, Nicholas J., de la Vega, Daniel J., O'Dea, Joanne, Nguyen, Kathy, McCormack, James E., Driver, David A., Townsend, Kay, Ibañez, Carlos E., Sajjadi, Nancy C., Greengard, Judith S., Moore, Margaret D., Respess, James, Chang, Stephen M.W., Dubensky, Thomas W., Jolly, Douglas J., Sauter, Sybille L.
Published in Molecular therapy (01.09.2000)
Published in Molecular therapy (01.09.2000)
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205. Cytotoxic and Immunotherapeutic Effects of Toca 511 and 5-Fluorocytosine in an Intraperitoneal Model of Metastatic Colorectal Cancer
Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Espinoza, Fernando Lopez, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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227. Cancer Cell Susceptibility To Treatment With a Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Is Likely To Be Common
Twitty, Chris G., Diago, Oscar R., Hogan, Daniel, Burrascano, Cindy, Ibanez, Carlos E., Jolly, Douglas J., Ostertag, Derek
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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Additive therapeutic effect of a non-lytic retroviral replicating vector (Toca 511) and 5-fluorocytosine in combination with lomustine in experimental glioma models
Robbins, Joan M., Huang, Tiffany T., Yagiz, Kader, Lopez Espinoza, Fernando, Martin, Bryan, Rodriguez-Aguirre, Maria, Ibanez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Abstract 708: Toca 511 gene therapy in combination with 5-fluorocytosine for intratumoral production of 5-fluorouracil in a colon cancer metastasis model
Rodriguez-Aguirre, Maria E., Espinoza, Fernando Lopez, Martin, Bryan, Yadiz, Kader, Huang, Tiffany T., Ibanez, Carlos E., Ostertag, Derek G., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model
Yin, D, Zhai, Y, Gruber, H E, Ibanez, C E, Robbins, J M, Kells, A P, Kasahara, N, Forsayeth, J, Jolly, D J, Bankiewicz, K S
Published in Cancer gene therapy (01.06.2013)
Published in Cancer gene therapy (01.06.2013)
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Ascending dose trials of the safety and tolerability of Toca 511, a retroviral replicating vector encoding cytosine deaminase, in patients with recurrent high-grade glioma
Pertschuk, Daniel, Cloughesy, Timothy Francis, Chang, Susan Marina, Aghi, Manish K., Vogelbaum, Michael A., Liau, Linda M., Shafa, Bob B., Yong, William H., Chen, Clark, Kesari, Santosh, Ibanez, Carlos E., Perez, Omar D., Robbins, Joan M., Jolly, Douglas J., Gruber, Harry E.
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Human cytomegalovirus productively infects primary differentiated macrophages
IBANEZ, C. E, SCHRIER, R, GHAZAL, P, WILEY, C, NELSON, J. A
Published in Journal of Virology (01.12.1991)
Published in Journal of Virology (01.12.1991)
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Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer
Dubensky, Jr, T W, Driver, D A, Polo, J M, Belli, B A, Latham, E M, Ibanez, C E, Chada, S, Brumm, D, Banks, T A, Mento, S J, Jolly, D J, Chang, S M
Published in Journal of Virology (01.01.1996)
Published in Journal of Virology (01.01.1996)
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