Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties
WOOD, Martyn D, SCOTT, Claire, FORBES, Ian T, GRIBBLE, Andrew, CLARKE, Kirsten, WESTAWAY, Julie, DAVIES, Ceri H, REAVILL, Charlie, HILL, Mark, ROURKE, Claire, NEWSON, Michael, JONES, Declan N. C
Published in European journal of pharmacology (28.09.2006)
Published in European journal of pharmacology (28.09.2006)
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CCR2: Characterization of the Antagonist Binding Site from a Combined Receptor Modeling/Mutagenesis Approach
Berkhout, Theo A, Blaney, Frank E, Bridges, Angela M, Cooper, David G, Forbes, Ian T, Gribble, Andrew D, Groot, Pieter H. E, Hardy, Adam, Ife, Robert J, Kaur, Rejbinder, Moores, Kitty E, Shillito, Helen, Willetts, Jennifer, Witherington, Jason
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Reverse Cope Elimination of Hydroxylamines and Alkenes or Alkynes: Theoretical Investigation of Tether Length and Substituent Effects
Krenske, Elizabeth H, Davison, Edwin C, Forbes, Ian T, Warner, Jacqueline A, Smith, Adrian L, Holmes, Andrew B, Houk, K. N
Published in Journal of the American Chemical Society (01.02.2012)
Published in Journal of the American Chemical Society (01.02.2012)
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Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist
Christopher J. Langmead, Victoria A. H. Fry, Ian T. Forbes, Clive L. Branch, Arthur Christopoulos, Martyn D. Wood, Hugh J. Herdon
Published in Molecular pharmacology (01.01.2006)
Published in Molecular pharmacology (01.01.2006)
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Identification of a novel series of selective 5-HT7 receptor antagonists
FORBES, Ian T, COOPER, David G, RILEY, Graham J, THOMAS, David R, DODDS, Emma K, DOUGLAS, Sara E, GRIBBLE, Andrew D, IFE, Robert J, LIGHTFOOT, Andrew P, MEESON, Malcolm, CAMPBELL, Lorraine P, COLEMAN, Tanya
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists
Budzik, Brian, Garzya, Vincenzo, Shi, Dongchuan, Walker, Graham, Woolley-Roberts, Marie, Pardoe, Joanne, Lucas, Adam, Tehan, Ben, Rivero, Ralph A, Langmead, Christopher J, Watson, Jeannette, Wu, Zining, Forbes, Ian T, Jin, Jian
Published in ACS medicinal chemistry letters (09.09.2010)
Published in ACS medicinal chemistry letters (09.09.2010)
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A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Lovell, Peter J, Bromidge, Steven M, Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T, Jennings, Andrew J, King, Frank D, Middlemiss, Derek N, Rahman, Shirley K, Saunders, Damian V, Collin, Lissa L, Hagan, Jim J, Riley, Graham J, Thomas, David R
Published in Journal of medicinal chemistry (10.02.2000)
Published in Journal of medicinal chemistry (10.02.2000)
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SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats
Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T
Published in British journal of pharmacology (01.06.2003)
Published in British journal of pharmacology (01.06.2003)
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2′ Biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling
Budzik, Brian, Garzya, Vincenzo, Shi, Dongchuan, Walker, Graham, Lauchart, Yann, Lucas, Adam J., Rivero, Ralph A., Langmead, Christopher J., Watson, Jeannette, Wu, Zining, Forbes, Ian T., Jin, Jian
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists
JOHNSON, Dale J, FORBES, Ian T, MURKITT, Graham S, LUCAS, Adam J, MOOKHERJEE, Claudette R, WATSON, Jeannette M, GARTLON, Jane E, BRADFORD, Andrea M, BROWN, Fiona, WATSON, Steve P, GARZYA, Vincenzo, STEVENSON, Graeme I, WALKER, Graham R, MUDHAR, Harminder S, FLYNN, Sean T, WYMAN, Paul A, SMITH, Paul W
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
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2′ Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR
Budzik, Brian, Garzya, Vincenzo, Shi, Dongchuan, Foley, James J., Rivero, Ralph A., Langmead, Christopher J., Watson, Jeannette, Wu, Zining, Forbes, Ian T., Jin, Jian
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Studies towards the identification of a new generation of atypical antipsychotic agents
Garzya, Vincenzo, Forbes, Ian T., Gribble, Andrew D., Hadley, Mike S., Lightfoot, Andrew P., Payne, Andrew H., Smith, Alexander B., Douglas, Sara E., Cooper, David G., Stansfield, Ian G., Meeson, Malcom, Dodds, Emma E., Jones, Declan N.C., Wood, Martyn, Reavill, Charlie, Scorer, Carol A., Worby, Angela, Riley, Graham, Eddershaw, Peter, Ioannou, Chris, Donati, Daniele, Hagan, Jim J., Ratti, Emiliangelo A.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist
Bromidge, Steven M, Duckworth, Malcolm, Forbes, Ian T, Ham, Peter, King, Frank D, Thewlis, Kevin M, Blaney, Frank E, Naylor, Christopher B, Blackburn, Thomas P, Kennett, Guy A, Wood, Martyn D, Clarke, Stephen E
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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SB-656104-A: A novel 5-HT7 receptor antagonist with improved in vivo properties
FORBES, Ian T, DOUGLAS, Sara, THOMAS, David R, GRIBBLE, Andrew D, IFE, Robert J, LIGHTFOOT, Andrew P, GARNER, Ashley E, RILEY, Graham J, JEFFREY, Phillip, STEVENS, Alexander J, STEAN, Tania O
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Functional characterisation of the human cloned 5‐HT7 receptor (long form); antagonist profile of SB‐258719
Thomas, David R., Gittins, Susan A., Collin, Lissa L., Middlemiss, Derek N., Riley, Graham, Hagan, Jim, Gloger, Israel, Ellis, Catherine E., Forbes, Ian T., Brown, Anthony M.
Published in British journal of pharmacology (01.07.1998)
Published in British journal of pharmacology (01.07.1998)
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Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
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