The Molecular Analysis for Therapy Choice (NCI-MATCH) Trial: Lessons for Genomic Trial Design
Flaherty, Keith T, Gray, Robert, Chen, Alice, Li, Shuli, Patton, David, Hamilton, Stanley R, Williams, Paul M, Mitchell, Edith P, Iafrate, A John, Sklar, Jeffrey, Harris, Lyndsay N, McShane, Lisa M, Rubinstein, Larry V, Sims, David J, Routbort, Mark, Coffey, Brent, Fu, Tony, Zwiebel, James A, Little, Richard F, Marinucci, Donna, Catalano, Robert, Magnan, Rick, Kibbe, Warren, Weil, Carol, Tricoli, James V, Alexander, Brian, Kumar, Shaji, Schwartz, Gary K, Meric-Bernstam, Funda, Lih, Chih-Jian, McCaskill-Stevens, Worta, Caimi, Paolo, Takebe, Naoko, Datta, Vivekananda, Arteaga, Carlos L, Abrams, Jeffrey S, Comis, Robert, O’Dwyer, Peter J, Conley, Barbara A
Published in JNCI : Journal of the National Cancer Institute (01.10.2020)
Published in JNCI : Journal of the National Cancer Institute (01.10.2020)
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Molecular Landscape and Actionable Alterations in a Genomically Guided Cancer Clinical Trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH)
Flaherty, Keith T, Gray, Robert J, Chen, Alice P, Li, Shuli, McShane, Lisa M, Patton, David, Hamilton, Stanley R, Williams, P Mickey, Iafrate, A John, Sklar, Jeffrey, Mitchell, Edith P, Harris, Lyndsay N, Takebe, Naoko, Sims, David J, Coffey, Brent, Fu, Tony, Routbort, Mark, Zwiebel, James A, Rubinstein, Larry V, Little, Richard F, Arteaga, Carlos L, Comis, Robert, Abrams, Jeffrey S, O'Dwyer, Peter J, Conley, Barbara A
Published in Journal of clinical oncology (20.11.2020)
Published in Journal of clinical oncology (20.11.2020)
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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.
Published in Cell (03.02.2022)
Published in Cell (03.02.2022)
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Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma
Gopal, Raj K., Kübler, Kirsten, Calvo, Sarah E., Polak, Paz, Livitz, Dimitri, Rosebrock, Daniel, Sadow, Peter M., Campbell, Braidie, Donovan, Samuel E., Amin, Salma, Gigliotti, Benjamin J., Grabarek, Zenon, Hess, Julian M., Stewart, Chip, Braunstein, Lior Z., Arndt, Peter F., Mordecai, Scott, Shih, Angela R., Chaves, Frances, Zhan, Tiannan, Lubitz, Carrie C., Kim, Jiwoong, Iafrate, A. John, Wirth, Lori, Parangi, Sareh, Leshchiner, Ignaty, Daniels, Gilbert H., Mootha, Vamsi K., Dias-Santagata, Dora, Getz, Gad, McFadden, David G.
Published in Cancer cell (13.08.2018)
Published in Cancer cell (13.08.2018)
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Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer
Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S, Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G, Mussolin, Benedetta, Kwak, Eunice L, Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A, Robinson, Hayley E, Hong, Theodore S, Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A John, Bardelli, Alberto, Corcoran, Ryan B
Published in Cancer discovery (01.02.2016)
Published in Cancer discovery (01.02.2016)
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Tsai, Shengdar Q, Zheng, Zongli, Nguyen, Nhu T, Liebers, Matthew, Topkar, Ved V, Thapar, Vishal, Wyvekens, Nicolas, Khayter, Cyd, Iafrate, A John, Le, Long P, Aryee, Martin J, Joung, J Keith
Published in Nature biotechnology (01.02.2015)
Published in Nature biotechnology (01.02.2015)
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MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib
LENNERZ, Jochen K, KWAK, Eunice L, SALGIA, Ravi, BANG, Yung-Jue, CLARK, Jeffrey W, SOLOMON, Benjamin J, JOHN IAFRATE, A, ACKERMAN, Allison, MICHAEL, Michael, FOX, Stephen B, BERGETHON, Kristin, LAUWERS, Gregory Y, CHRISTENSEN, James G, WILNER, Keith D, HABER, Daniel A
Published in Journal of clinical oncology (20.12.2011)
Published in Journal of clinical oncology (20.12.2011)
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Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
Snuderl, Matija, Fazlollahi, Ladan, Le, Long P., Nitta, Mai, Zhelyazkova, Boryana H., Davidson, Christian J., Akhavanfard, Sara, Cahill, Daniel P., Aldape, Kenneth D., Betensky, Rebecca A., Louis, David N., Iafrate, A. John
Published in Cancer cell (13.12.2011)
Published in Cancer cell (13.12.2011)
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Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping
Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias‐Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John
Published in The oncologist (Dayton, Ohio) (01.01.2012)
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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Venteicher, Andrew S., Tirosh, Itay, Hebert, Christine, Yizhak, Keren, Neftel, Cyril, Filbin, Mariella G., Hovestadt, Volker, Escalante, Leah E., Shaw, McKenzie L., Rodman, Christopher, Gillespie, Shawn M., Dionne, Danielle, Luo, Christina C., Ravichandran, Hiranmayi, Mylvaganam, Ravindra, Mount, Christopher, Onozato, Maristela L., Nahed, Brian V., Wakimoto, Hiroaki, Curry, William T., Iafrate, A. John, Rivera, Miguel N., Frosch, Matthew P., Golub, Todd R., Brastianos, Priscilla K., Getz, Gad, Patel, Anoop P., Monje, Michelle, Cahill, Daniel P., Rozenblatt-Rosen, Orit, Louis, David N., Bernstein, Bradley E., Regev, Aviv, Suvà, Mario L.
Published in Science (American Association for the Advancement of Science) (31.03.2017)
Published in Science (American Association for the Advancement of Science) (31.03.2017)
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Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers
Li, Chenguang, Fang, Rong, Sun, Yihua, Han, Xiangkun, Li, Fei, Gao, Bin, Iafrate, A John, Liu, Xin-Yuan, Pao, William, Chen, Haiquan, Ji, Hongbin
Published in PloS one (30.11.2011)
Published in PloS one (30.11.2011)
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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Shaw, Alice T, Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F, Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J, Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L, Schultz, Kate R, Logan, Jennifer, James, Leonard P, Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W, Engelman, Jeffrey A
Published in The New England journal of medicine (07.01.2016)
Published in The New England journal of medicine (07.01.2016)
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Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish
Yan, Chuan, Brunson, Dalton C., Tang, Qin, Do, Daniel, Iftimia, Nicolae A., Moore, John C., Hayes, Madeline N., Welker, Alessandra M., Garcia, Elaine G., Dubash, Taronish D., Hong, Xin, Drapkin, Benjamin J., Myers, David T., Phat, Sarah, Volorio, Angela, Marvin, Dieuwke L., Ligorio, Matteo, Dershowitz, Lyle, McCarthy, Karin M., Karabacak, Murat N., Fletcher, Jonathan A., Sgroi, Dennis C., Iafrate, John A., Maheswaran, Shyamala, Dyson, Nick J., Haber, Daniel A., Rawls, John F., Langenau, David M.
Published in Cell (13.06.2019)
Published in Cell (13.06.2019)
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Anchored multiplex PCR for targeted next-generation sequencing
Zheng, Zongli, Liebers, Matthew, Zhelyazkova, Boryana, Cao, Yi, Panditi, Divya, Lynch, Kerry D, Chen, Juxiang, Robinson, Hayley E, Shim, Hyo Sup, Chmielecki, Juliann, Pao, William, Engelman, Jeffrey A, Iafrate, A John, Le, Long Phi
Published in Nature medicine (01.12.2014)
Published in Nature medicine (01.12.2014)
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Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer
Shaw, Alice T, Ou, Sai-Hong I, Bang, Yung-Jue, Camidge, D. Ross, Solomon, Benjamin J, Salgia, Ravi, Riely, Gregory J, Varella-Garcia, Marileila, Shapiro, Geoffrey I, Costa, Daniel B, Doebele, Robert C, Le, Long Phi, Zheng, Zongli, Tan, Weiwei, Stephenson, Patricia, Shreeve, S. Martin, Tye, Lesley M, Christensen, James G, Wilner, Keith D, Clark, Jeffrey W, Iafrate, A. John
Published in The New England journal of medicine (20.11.2014)
Published in The New England journal of medicine (20.11.2014)
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The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1 -Mutant Cancers and Potentiates NAD + Depletion-Mediated Cytotoxicity
Tateishi, Kensuke, Higuchi, Fumi, Miller, Julie J, Koerner, Mara V A, Lelic, Nina, Shankar, Ganesh M, Tanaka, Shota, Fisher, David E, Batchelor, Tracy T, Iafrate, A John, Wakimoto, Hiroaki, Chi, Andrew S, Cahill, Daniel P
Published in Cancer research (Chicago, Ill.) (01.08.2017)
Published in Cancer research (Chicago, Ill.) (01.08.2017)
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Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer
Dagogo-Jack, Ibiayi, Martinez, Pablo, Yeap, Beow Y, Ambrogio, Chiara, Ferris, Lorin A, Lydon, Christine, Nguyen, Tom, Jessop, Nicholas A, Iafrate, A John, Johnson, Bruce E, Lennerz, Jochen K, Shaw, Alice T, Awad, Mark M
Published in Clinical cancer research (01.01.2019)
Published in Clinical cancer research (01.01.2019)
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A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations
Voss, Martin H, Hierro, Cinta, Heist, Rebecca S, Cleary, James M, Meric-Bernstam, Funda, Tabernero, Josep, Janku, Filip, Gandhi, Leena, Iafrate, A John, Borger, Darrell R, Ishii, Nobuya, Hu, Youyou, Kirpicheva, Yulia, Nicolas-Metral, Valerie, Pokorska-Bocci, Anna, Vaslin Chessex, Anne, Zanna, Claudio, Flaherty, Keith T, Baselga, Jose
Published in Clinical cancer research (01.05.2019)
Published in Clinical cancer research (01.05.2019)
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Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays
Merker, Jason D, Devereaux, Kelly, Iafrate, A John, Kamel-Reid, Suzanne, Kim, Annette S, Moncur, Joel T, Montgomery, Stephen B, Nagarajan, Rakesh, Portier, Bryce P, Routbort, Mark J, Smail, Craig, Surrey, Lea F, Vasalos, Patricia, Lazar, Alexander J, Lindeman, Neal I
Published in Archives of pathology & laboratory medicine (1976) (01.04.2019)
Published in Archives of pathology & laboratory medicine (1976) (01.04.2019)
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Brain tumor cells in circulation are enriched for mesenchymal gene expression
Sullivan, James P, Nahed, Brian V, Madden, Marissa W, Oliveira, Samantha M, Springer, Simeon, Bhere, Deepak, Chi, Andrew S, Wakimoto, Hiroaki, Rothenberg, S Michael, Sequist, Lecia V, Kapur, Ravi, Shah, Khalid, Iafrate, A John, Curry, William T, Loeffler, Jay S, Batchelor, Tracy T, Louis, David N, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A
Published in Cancer discovery (01.11.2014)
Published in Cancer discovery (01.11.2014)
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