Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014
Pirrone, Gregory F, Iacob, Roxana E, Engen, John R
Published in Analytical chemistry (Washington) (06.01.2015)
Published in Analytical chemistry (Washington) (06.01.2015)
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Journal Article
Force interacts with macromolecular structure in activation of TGF-β
Dong, Xianchi, Zhao, Bo, Iacob, Roxana E, Zhu, Jianghai, Koksal, Adem C, Lu, Chafen, Engen, John R, Springer, Timothy A
Published in Nature (London) (02.02.2017)
Published in Nature (London) (02.02.2017)
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Journal Article
Structural mechanism of a drug-binding process involving a large conformational change of the protein target
Ayaz, Pelin, Lyczek, Agatha, Paung, YiTing, Mingione, Victoria R, Iacob, Roxana E, de Waal, Parker W, Engen, John R, Seeliger, Markus A, Shan, Yibing, Shaw, David E
Published in Nature communications (05.04.2023)
Published in Nature communications (05.04.2023)
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Journal Article
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Masson, Glenn R, Burke, John E, Ahn, Natalie G, Anand, Ganesh S, Borchers, Christoph, Brier, Sébastien, Bou-Assaf, George M, Engen, John R, Englander, S Walter, Faber, Johan, Garlish, Rachel, Griffin, Patrick R, Gross, Michael L, Guttman, Miklos, Hamuro, Yoshitomo, Heck, Albert J R, Houde, Damian, Iacob, Roxana E, Jørgensen, Thomas J D, Kaltashov, Igor A, Klinman, Judith P, Konermann, Lars, Man, Petr, Mayne, Leland, Pascal, Bruce D, Reichmann, Dana, Skehel, Mark, Snijder, Joost, Strutzenberg, Timothy S, Underbakke, Eric S, Wagner, Cornelia, Wales, Thomas E, Walters, Benjamin T, Weis, David D, Wilson, Derek J, Wintrode, Patrick L, Zhang, Zhongqi, Zheng, Jie, Schriemer, David C, Rand, Kasper D
Published in Nature methods (01.07.2019)
Published in Nature methods (01.07.2019)
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Journal Article
Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7
Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J., Iacob, Roxana E., Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L., Engen, John R., Anderson, Kenneth C., Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J.
Published in Cell chemical biology (21.12.2017)
Published in Cell chemical biology (21.12.2017)
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Journal Article
General structural features that regulate integrin affinity revealed by atypical αVβ8
Wang, Jianchuan, Su, Yang, Iacob, Roxana E, Engen, John R, Springer, Timothy A
Published in Nature communications (02.12.2019)
Published in Nature communications (02.12.2019)
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Journal Article
Hydrogen Exchange Mass Spectrometry: Are We Out of the Quicksand?
Iacob, Roxana E., Engen, John R.
Published in Journal of the American Society for Mass Spectrometry (01.06.2012)
Published in Journal of the American Society for Mass Spectrometry (01.06.2012)
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Journal Article
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
Wei, Hui, Mo, Jingjie, Tao, Li, Russell, Reb J., Tymiak, Adrienne A., Chen, Guodong, Iacob, Roxana E., Engen, John R.
Published in Drug discovery today (01.01.2014)
Published in Drug discovery today (01.01.2014)
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Journal Article
Structure and Dynamic Regulation of Abl Kinases
Panjarian, Shoghag, Iacob, Roxana E., Chen, Shugui, Engen, John R., Smithgall, Thomas E.
Published in The Journal of biological chemistry (22.02.2013)
Published in The Journal of biological chemistry (22.02.2013)
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Journal Article
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
Yun, Cai-Hong, Chirieac, Lucian, Iacob, Roxana E, Padera, Robert, Zhou, Wenjun, Eck, Michael J, Engen, John R, Chen, Liang, Gray, Nathanael S, Jänne, Pasi A, Li, Danan, Capelletti, Marzia, Cortot, Alexis B, Ercan, Dalia, Wong, Kwok-Kin
Published in Nature (London) (24.12.2009)
Published in Nature (London) (24.12.2009)
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Journal Article
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
Iacob, Roxana E, Zhang, Jianming, Gray, Nathanael S, Engen, John R
Published in PloS one (10.01.2011)
Published in PloS one (10.01.2011)
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Journal Article
Differential sensitivity of Src-family kinases to activation by SH3 domain displacement
Moroco, Jamie A, Craigo, Jodi K, Iacob, Roxana E, Wales, Thomas E, Engen, John R, Smithgall, Thomas E
Published in PloS one (21.08.2014)
Published in PloS one (21.08.2014)
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Journal Article
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Yu, Wenyu, Chory, Emma J, Wernimont, Amy K, Tempel, Wolfram, Scopton, Alex, Federation, Alexander, Marineau, Jason J, Qi, Jun, Barsyte-Lovejoy, Dalia, Yi, Joanna, Marcellus, Richard, Iacob, Roxana E, Engen, John R, Griffin, Carly, Aman, Ahmed, Wienholds, Erno, Li, Fengling, Pineda, Javier, Estiu, Guillermina, Shatseva, Tatiana, Hajian, Taraneh, Al-Awar, Rima, Dick, John E, Vedadi, Masoud, Brown, Peter J, Arrowsmith, Cheryl H, Bradner, James E, Schapira, Matthieu
Published in Nature communications (01.12.2012)
Published in Nature communications (01.12.2012)
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Journal Article
Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation
Le, Viet Q, Iacob, Roxana E, Tian, Yuan, McConaughy, William, Jackson, Justin, Su, Yang, Zhao, Bo, Engen, John R, Pirruccello‐Straub, Michelle, Springer, Timothy A
Published in The EMBO journal (01.02.2018)
Published in The EMBO journal (01.02.2018)
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Journal Article
Emerging Therapeutic Approaches and Genetic Insights in Stargardt Disease: A Comprehensive Review
Ghenciu, Laura Andreea, Hațegan, Ovidiu Alin, Stoicescu, Emil Robert, Iacob, Roxana, Șișu, Alina Maria
Published in International journal of molecular sciences (14.08.2024)
Published in International journal of molecular sciences (14.08.2024)
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Journal Article
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
Schauer, Nathan J, Liu, Xiaoxi, Magin, Robert S, Doherty, Laura M, Chan, Wai Cheung, Ficarro, Scott B, Hu, Wanyi, Roberts, Rebekka M, Iacob, Roxana E, Stolte, Björn, Giacomelli, Andrew O, Perera, Sumner, McKay, Kyle, Boswell, Sarah A, Weisberg, Ellen L, Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C, Griffin, James D, Li, Jianing, Hahn, William C, Sorger, Peter K, Engen, John R, Stegmaier, Kimberly, Marto, Jarrod A, Buhrlage, Sara J
Published in Scientific reports (24.03.2020)
Published in Scientific reports (24.03.2020)
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Journal Article
Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family
Le, Viet Q., Iacob, Roxana E., Zhao, Bo, Su, Yang, Tian, Yuan, Toohey, Cameron, Engen, John R., Springer, Timothy A.
Published in Journal of molecular biology (15.03.2022)
Published in Journal of molecular biology (15.03.2022)
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Journal Article
Fusion surface structure, function, and dynamics of gamete fusogen HAP2
Feng, Juan, Dong, Xianchi, Pinello, Jennifer, Zhang, Jun, Lu, Chafen, Iacob, Roxana E, Engen, John R, Snell, William J, Springer, Timothy A
Published in eLife (03.10.2018)
Published in eLife (03.10.2018)
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Journal Article