STING enhances cell death through regulation of reactive oxygen species and DNA damage
Hayman, Thomas J., Baro, Marta, MacNeil, Tyler, Phoomak, Chatchai, Aung, Thazin Nwe, Cui, Wei, Leach, Kevin, Iyer, Radhakrishnan, Challa, Sreerupa, Sandoval-Schaefer, Teresa, Burtness, Barbara A., Rimm, David L., Contessa, Joseph N.
Published in Nature communications (19.04.2021)
Published in Nature communications (19.04.2021)
Get full text
Journal Article
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
Neufeldt, Christopher J., Cerikan, Berati, Cortese, Mirko, Frankish, Jamie, Lee, Ji-Young, Plociennikowska, Agnieszka, Heigwer, Florian, Prasad, Vibhu, Joecks, Sebastian, Burkart, Sandy S., Zander, David Y., Subramanian, Baskaran, Gimi, Rayomand, Padmanabhan, Seetharamaiyer, Iyer, Radhakrishnan, Gendarme, Mathieu, El Debs, Bachir, Halama, Niels, Merle, Uta, Boutros, Michael, Binder, Marco, Bartenschlager, Ralf
Published in Communications biology (12.01.2022)
Published in Communications biology (12.01.2022)
Get full text
Journal Article
Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks
Suresh, Manasa, Korolowicz, Kyle E, Balarezo, Maria, Iyer, Radhakrishnan P, Padmanabhan, Seetharamaiyer, Cleary, Dillon, Gimi, Rayomand, Sheri, Anjaneyulu, Yon, Changsuek, Kallakury, Bhaskar V, Tucker, Robin D, Afdhal, Nezam, Menne, Stephan
Published in PloS one (05.01.2017)
Published in PloS one (05.01.2017)
Get full text
Journal Article
Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B
Korolowicz, Kyle E, Iyer, Radhakrishnan P, Czerwinski, Stefanie, Suresh, Manasa, Yang, Junming, Padmanabhan, Seetharamaiyer, Sheri, Anjaneyulu, Pandey, Rajendra K, Skell, Jeffrey, Marquis, Judith K, Kallakury, Bhaskar V, Tucker, Robin D, Menne, Stephan
Published in PloS one (23.08.2016)
Published in PloS one (23.08.2016)
Get full text
Journal Article
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice
Khan, Arshad, Singh, Vipul K, Mishra, Abhishek, Soudani, Emily, Bakhru, Pearl, Singh, Christopher R, Zhang, Dekai, Canaday, David H, Sheri, Anjaneyulu, Padmanabhan, Seetharamaiyer, Challa, Sreerupa, Iyer, Radhakrishnan P, Jagannath, Chinnaswamy
Published in Frontiers in immunology (07.12.2020)
Published in Frontiers in immunology (07.12.2020)
Get full text
Journal Article
SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants
Jones, Meleri, Cunningham, Morven E., Wing, Peter, DeSilva, Sampath, Challa, Rupa, Sheri, Anjaneyulu, Padmanabhan, Seetharamaiyer, Iyer, Radhakrishnan P., Korba, Brent E., Afdhal, Nezam, Foster, Graham R.
Published in Journal of medical virology (01.09.2017)
Published in Journal of medical virology (01.09.2017)
Get full text
Journal Article
Bilateral pseudohypopyon causing white eyes in a patient with lymphoma
Iyer, Siva S Radhakrishnan, Jin, Zhongbo, Seifert, Robert P, Dang, Nam H
Published in The Lancet (British edition) (25.04.2020)
Published in The Lancet (British edition) (25.04.2020)
Get full text
Journal Article
A phase 2, open‐label, randomized, multiple‐dose study evaluating Inarigivir in treatment‐naïve patients with chronic hepatitis B
Yuen, Man‐Fung, Chen, Chi‐Yi, Liu, Chun‐Jen, Jeng, Wen‐Juei, Elkhashab, Magdy, Coffin, Carla S., Kim, Won, Greenbloom, Susan, Ramji, Alnoor, Lim, Young S., Kim, Yoon J., Fung, Scott K., Kim, Dong J., Jang, Jeong‐Won, Lee, Kwan Sik, Iyer, Radhakrishnan P., Macfarlane, Chelsea, Jackson, Kathy, Locarnini, Stephen A., Chan, Henry L. Y., Afdhal, Nezam H.
Published in Liver international (01.01.2023)
Published in Liver international (01.01.2023)
Get full text
Journal Article
Nucleobase Protection of Deoxyribo- and Ribonucleosides
Meher, Geeta, Meher, Nabin K, Iyer, Radhakrishnan P
Published in Current protocols in nucleic acid chemistry (01.06.2017)
Published in Current protocols in nucleic acid chemistry (01.06.2017)
Get more information
Journal Article
Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate
Coughlin, John E, Pandey, Rajendra K, Padmanabhan, Seetharamaiyer, O'Loughlin, Kathleen G, Marquis, Judith, Green, Carol E, Mirsalis, Jon C, Iyer, Radhakrishnan P
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
Get full text
Journal Article
In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a 'parallel progression approach to drug design' applied to β-blockers
Advani, Poonam, Joseph, Blessy, Ambre, Premlata, Pissurlenkar, Raghuvir, Khedkar, Vijay, Iyer, Krishna, Gabhe, Satish, Iyer, Radhakrishnan P., Coutinho, Evans
Published in Journal of biomolecular structure & dynamics (01.01.2016)
Published in Journal of biomolecular structure & dynamics (01.01.2016)
Get full text
Journal Article
Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives
Pedgaonkar, Yogesh Y, Degani, Mariam S, Iyer, Radhakrishnan P
Published in Molecular diversity (01.02.2011)
Published in Molecular diversity (01.02.2011)
Get full text
Journal Article
Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs
Coughlin, John E., Padmanabhan, Seetharamaiyer, Zhang, Guangrong, Kirk, Cassandra J., Govardhan, Chandrika P., Korba, Brent E., O’Loughlin, Kathleen, Green, Carol E., Mirsalis, Jon, Morrey, John D., Iyer, Radhakrishnan P.
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Get full text
Journal Article
Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model
IYER, Radhakrishnan P, ROLAND, Arlene, YI JIN, MOUNIR, Samir, KORBA, Brent, JULANDER, Justin G, MORREY, John D
Published in Antimicrobial Agents and Chemotherapy (01.06.2004)
Published in Antimicrobial Agents and Chemotherapy (01.06.2004)
Get full text
Journal Article
Nucleotide analogs as novel anti-hepatitis B virus agents
Iyer, Radhakrishnan P, Padmanabhan, Seetharamaiyer, Zhang, Guangrong, Morrey, John D, Korba, Brent E
Published in Current opinion in pharmacology (01.10.2005)
Published in Current opinion in pharmacology (01.10.2005)
Get full text
Journal Article