Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
Suzuki, Takafumi, Muramatsu, Aki, Saito, Ryota, Iso, Tatsuro, Shibata, Takahiro, Kuwata, Keiko, Kawaguchi, Shin-ichi, Iwawaki, Takao, Adachi, Saki, Suda, Hiromi, Morita, Masanobu, Uchida, Koji, Baird, Liam, Yamamoto, Masayuki
Published in Cell reports (Cambridge) (16.07.2019)
Published in Cell reports (Cambridge) (16.07.2019)
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Journal Article
Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress
Sekiguchi, Akiko, Motegi, Sei-Ichiro, Fujiwara, Chisako, Yamazaki, Sahori, Inoue, Yuta, Uchiyama, Akihiko, Akai, Ryoko, Iwawaki, Takao, Ishikawa, Osamu
Published in Journal of dermatological science (01.10.2019)
Published in Journal of dermatological science (01.10.2019)
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Journal Article
Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells
Liu, Lu, Zhao, Meiling, Jin, Xi, Ney, Gina, Yang, Kevin B, Peng, Fanglue, Cao, Jin, Iwawaki, Takao, Del Valle, Juan, Chen, Xi, Li, Qing
Published in Nature cell biology (01.03.2019)
Published in Nature cell biology (01.03.2019)
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Journal Article
Paneth cells as a site of origin for intestinal inflammation
Adolph, Timon E., Tomczak, Michal F., Niederreiter, Lukas, Ko, Hyun-Jeong, Böck, Janne, Martinez-Naves, Eduardo, Glickman, Jonathan N., Tschurtschenthaler, Markus, Hartwig, John, Hosomi, Shuhei, Flak, Magdalena B., Cusick, Jennifer L., Kohno, Kenji, Iwawaki, Takao, Billmann-Born, Susanne, Raine, Tim, Bharti, Richa, Lucius, Ralph, Kweon, Mi-Na, Marciniak, Stefan J., Choi, Augustine, Hagen, Susan J., Schreiber, Stefan, Rosenstiel, Philip, Kaser, Arthur, Blumberg, Richard S.
Published in Nature (London) (14.11.2013)
Published in Nature (London) (14.11.2013)
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Journal Article
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain
Chopra, Sahil, Giovanelli, Paolo, Alvarado-Vazquez, Perla Abigail, Alonso, Sara, Song, Minkyung, Sandoval, Tito A, Chae, Chang-Suk, Tan, Chen, Fonseca, Miriam M, Gutierrez, Silvia, Jimenez, Leandro, Subbaramaiah, Kotha, Iwawaki, Takao, Kingsley, Philip J, Marnett, Lawrence J, Kossenkov, Andrew V, Crespo, Mariano Sanchez, Dannenberg, Andrew J, Glimcher, Laurie H, Romero-Sandoval, E Alfonso, Cubillos-Ruiz, Juan R
Published in Science (American Association for the Advancement of Science) (19.07.2019)
Published in Science (American Association for the Advancement of Science) (19.07.2019)
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Journal Article
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions
Xu, Longyong, Liu, Xia, Peng, Fanglue, Zhang, Weijie, Zheng, Liting, Ding, Yao, Gu, Tianpeng, Lv, Kaosheng, Wang, Jin, Ortinau, Laura, Hu, Tianyuan, Shi, Xiangguo, Shi, Guojun, Shang, Ge, Sun, Shengyi, Iwawaki, Takao, Ji, Yewei, Li, Wei, Rosen, Jeffrey M., Zhang, Xiang H.-F., Park, Dongsu, Adoro, Stanley, Catic, Andre, Tong, Wei, Qi, Ling, Nakada, Daisuke, Chen, Xi
Published in Nature cell biology (01.10.2020)
Published in Nature cell biology (01.10.2020)
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Journal Article
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis
Tschurtschenthaler, Markus, Adolph, Timon E, Ashcroft, Jonathan W, Niederreiter, Lukas, Bharti, Richa, Saveljeva, Svetlana, Bhattacharyya, Joya, Flak, Magdalena B, Shih, David Q, Fuhler, Gwenny M, Parkes, Miles, Kohno, Kenji, Iwawaki, Takao, Janneke van der Woude, C, Harding, Heather P, Smith, Andrew M, Peppelenbosch, Maikel P, Targan, Stephan R, Ron, David, Rosenstiel, Philip, Blumberg, Richard S, Kaser, Arthur
Published in The Journal of experimental medicine (01.02.2017)
Published in The Journal of experimental medicine (01.02.2017)
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Journal Article
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Duwaerts, Caroline C., Siao, Kevin, Soon, Russell K., Her, Chris, Iwawaki, Takao, Kohno, Kenji, Mattis, Aras N., Maher, Jacquelyn J.
Published in Cell death and differentiation (01.05.2021)
Published in Cell death and differentiation (01.05.2021)
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Journal Article
IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival
Batista, Alyssa, Rodvold, Jeffrey J, Xian, Su, Searles, Stephen C, Lew, Alyssa, Iwawaki, Takao, Almanza, Gonzalo, Waller, T Cameron, Lin, Jonathan, Jepsen, Kristen, Carter, Hannah, Zanetti, Maurizio
Published in PLoS biology (01.06.2020)
Published in PLoS biology (01.06.2020)
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Journal Article
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity
Uzi, Dotan, Barda, Liran, Scaiewicz, Viviana, Mills, Maya, Mueller, Tobias, Gonzalez-Rodriguez, Agueda, Valverde, Angela M, Iwawaki, Takao, Nahmias, Yaacov, Xavier, Ramnik, Chung, Ray T, Tirosh, Boaz, Shibolet, Oren
Published in Journal of hepatology (01.09.2013)
Published in Journal of hepatology (01.09.2013)
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Journal Article
Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β
Oikawa, Daisuke, Kitamura, Akira, Kinjo, Masataka, Iwawaki, Takao
Published in PloS one (07.12.2012)
Published in PloS one (07.12.2012)
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Journal Article
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
Roy, Anirban, Tomaz da Silva, Meiricris, Bhat, Raksha, Bohnert, Kyle R, Iwawaki, Takao, Kumar, Ashok
Published in eLife (23.11.2021)
Published in eLife (23.11.2021)
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Journal Article
ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
Chapple, Richard H, Hu, Tianyuan, Tseng, Yu-Jung, Liu, Lu, Kitano, Ayumi, Luu, Victor, Hoegenauer, Kevin A, Iwawaki, Takao, Li, Qing, Nakada, Daisuke
Published in eLife (16.02.2018)
Published in eLife (16.02.2018)
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Journal Article
Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model
Yamazaki, Sahori, Sekiguchi, Akiko, Uchiyama, Akihiko, Fujiwara, Chisako, Inoue, Yuta, Yokoyama, Yoko, Ogino, Sachiko, Torii, Ryoko, Hosoi, Mari, Akai, Ryoko, Iwawaki, Takao, Ishikawa, Osamu, Motegi, Sei-ichiro
Published in Scientific reports (28.01.2020)
Published in Scientific reports (28.01.2020)
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Journal Article
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Jiang, Dadi, Guo, Youming, Wang, Tianyu, Wang, Liang, Yan, Yuelong, Xia, Ling, Bam, Rakesh, Yang, Zhifen, Lee, Hyemin, Iwawaki, Takao, Gan, Boyi, Koong, Albert C.
Published in Nature communications (15.05.2024)
Published in Nature communications (15.05.2024)
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Journal Article
Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response
Clément, Marc, Basatemur, Gemma, Masters, Leanne, Baker, Lauren, Bruneval, Patrick, Iwawaki, Takao, Kneilling, Manfred, Yamasaki, Sho, Goodall, Jane, Mallat, Ziad
Published in Circulation (New York, N.Y.) (04.10.2016)
Published in Circulation (New York, N.Y.) (04.10.2016)
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Journal Article
Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells
Robblee, Megan M., Kim, Charles C., Abate, Jess Porter, Valdearcos, Martin, Sandlund, Karin L.M., Shenoy, Meera K., Volmer, Romain, Iwawaki, Takao, Koliwad, Suneil K.
Published in Cell reports (Cambridge) (22.03.2016)
Published in Cell reports (Cambridge) (22.03.2016)
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Journal Article
Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress
Nakato, Ryosuke, Ohkubo, Yu, Konishi, Akari, Shibata, Mari, Kaneko, Yuki, Iwawaki, Takao, Nakamura, Tomohiro, Lipton, Stuart A., Uehara, Takashi
Published in Scientific reports (08.10.2015)
Published in Scientific reports (08.10.2015)
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