Importance of cynomolgus monkeys in development of monoclonal antibody drugs
Iwasaki, Kazuhide, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi
Published in Drug metabolism and pharmacokinetics (01.02.2019)
Published in Drug metabolism and pharmacokinetics (01.02.2019)
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Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo
Utoh, Masahiro, Yoshikawa, Takahiro, Hayashi, Yoshiharu, Shimizu, Makiko, Iwasaki, Kazuhide, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in Biochemical pharmacology (15.05.2015)
Published in Biochemical pharmacology (15.05.2015)
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Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose
Ieiri, Ichiro, Doi, Yohei, Maeda, Kazuya, Sasaki, Tomohiro, Kimura, Miyuki, Hirota, Takeshi, Chiyoda, Takeshi, Miyagawa, Mayuko, Irie, Shin, Iwasaki, Kazuhide, Sugiyama, Yuichi
Published in Journal of clinical pharmacology (01.07.2012)
Published in Journal of clinical pharmacology (01.07.2012)
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Journal Article
Polymorphisms of Neonatal Fc Receptor in Cynomolgus and Rhesus Macaques
Uno, Yasuhiro, Utoh, Masahiro, Iwasaki, Kazuhide
Published in DRUG METABOLISM AND PHARMACOKINETICS (2014)
Published in DRUG METABOLISM AND PHARMACOKINETICS (2014)
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Journal Article
Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450
Yajima, Kanako, Uno, Yasuhiro, Murayama, Norie, Uehara, Shotaro, Shimizu, Makiko, Nakamura, Chika, Iwasaki, Kazuhide, Utoh, Masahiro, Yamazaki, Hiroshi
Published in Drug metabolism and disposition (01.05.2014)
Published in Drug metabolism and disposition (01.05.2014)
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Journal Article
Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase
Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Shimizu, Makiko, Uehara, Shotaro, Fujino, Hideki, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in Drug metabolism and disposition (01.01.2015)
Published in Drug metabolism and disposition (01.01.2015)
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Journal Article
Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase
Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Uehara, Shotaro, Shimizu, Makiko, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in Drug metabolism and disposition (01.07.2015)
Published in Drug metabolism and disposition (01.07.2015)
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Journal Article
Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies
Murayama, Norie, Yajima, Kanako, Hikawa, Mikiko, Shimura, Kanami, Ishii, Yu, Takada, Masaki, Uno, Yasuhiro, Utoh, Masahiro, Iwasaki, Kazuhide, Yamazaki, Hiroshi
Published in Biopharmaceutics & drug disposition (01.02.2018)
Published in Biopharmaceutics & drug disposition (01.02.2018)
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Journal Article
Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles
Emoto, Chie, Yoda, Noriaki, Uno, Yasuhiro, Iwasaki, Kazuhide, Umehara, Ken, Kashiyama, Eiji, Yamazaki, Hiroshi
Published in Current drug metabolism (01.02.2013)
Published in Current drug metabolism (01.02.2013)
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Journal Article
Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs
Mogi, Masayuki, Toda, Akiko, Iwasaki, Kazuhide, Kusumoto, Shogo, Takehara, Hiromi, Shimizu, Makiko, Murayama, Norie, Izumi, Hiroyuki, Utoh, Masahiro, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2012)
Published in Journal of toxicological sciences (2012)
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Journal Article
Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes
Uno, Yasuhiro, Fujino, Hideki, Iwasaki, Kazuhide, Utoh, Masahiro
Published in Current drug metabolism (01.02.2010)
Published in Current drug metabolism (01.02.2010)
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Journal Article
Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans
Iwasaki, Kazuhide, Murayama, Norie, Koizumi, Ryo, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2010)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2010)
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Journal Article
In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9
Iwasaki, Kazuhide, Kitsugi, Yusuke, Ikeda, Kanami, Yoshikawa, Takahiro, Hosaka, Shinya, Uehara, Shotaro, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi
Published in Biopharmaceutics & drug disposition (01.09.2016)
Published in Biopharmaceutics & drug disposition (01.09.2016)
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Journal Article
Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys
Nakanishi, Yasuharu, Matsushita, Akinori, Matsuno, Kiyomi, Iwasaki, Kazuhide, Utoh, Masahiro, Nakamura, Chika, Uno, Yasuhiro
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2010)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2010)
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Journal Article
Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey
Uno, Yasuhiro, Uehara, Shotaro, Kohara, Sakae, Iwasaki, Kazuhide, Nagata, Ryoichi, Fukuzaki, Koichiro, Utoh, Masahiro, Murayama, Norie, Yamazaki, Hiroshi
Published in PloS one (08.02.2011)
Published in PloS one (08.02.2011)
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Journal Article
Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances
Hosaka, Shinya, Murayama, Norie, Satsukawa, Masahiro, Uehara, Shotaro, Shimizu, Makiko, Iwasaki, Kazuhide, Iwano, Shunsuke, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in Biopharmaceutics & drug disposition (01.12.2015)
Published in Biopharmaceutics & drug disposition (01.12.2015)
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Journal Article
Effect of CYP2C9 genotype for pharmacokinetics of efavirenz in vivo in cynomolgus monkeys
Iwasaki, Kazuhide, Kitsugi, Yusuke, Ikeda, Kanami, Yoshikawa, Takahiro, Uehara, Shotaro, Uno, Yasuhiro, Utoh, Masahiro, Yamazaki, Hiroshi
Published in Drug metabolism and pharmacokinetics (01.01.2017)
Published in Drug metabolism and pharmacokinetics (01.01.2017)
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Journal Article
EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
KATOH, Miki, MATSUI, Tomohito, NAKAJIMA, Miki, TATENO, Chise, KATAOKA, Miho, SOENO, Yoshinori, HORIE, Toru, IWASAKI, Kazuhide, YOSHIZATO, Katsutoshi, YOKOI, Tsuyoshi
Published in Drug metabolism and disposition (01.12.2004)
Published in Drug metabolism and disposition (01.12.2004)
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Journal Article
Regional Distribution of Drug-metabolizing Enzyme Activities in the Liver and Small Intestine of Cynomolgus Monkeys
Nakanishi, Yasuharu, Matsushita, Akinori, Matsuno, Kiyomi, Iwasaki, Kazuhide, Utoh, Masahiro, Nakamura, Chika, Uno, Yasuhiro
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
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