Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
Lapuente, Dennis, Fuchs, Jana, Willar, Jonas, Vieira Antão, Ana, Eberlein, Valentina, Uhlig, Nadja, Issmail, Leila, Schmidt, Anna, Oltmanns, Friederike, Peter, Antonia Sophia, Mueller-Schmucker, Sandra, Irrgang, Pascal, Fraedrich, Kirsten, Cara, Andrea, Hoffmann, Markus, Pöhlmann, Stefan, Ensser, Armin, Pertl, Cordula, Willert, Torsten, Thirion, Christian, Grunwald, Thomas, Überla, Klaus, Tenbusch, Matthias
Published in Nature communications (26.11.2021)
Published in Nature communications (26.11.2021)
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Immunization with different recombinant West Nile virus envelope proteins induces varying levels of serological cross-reactivity and protection from infection
Weiß, Rebecca, Issmail, Leila, Rockstroh, Alexandra, Grunwald, Thomas, Fertey, Jasmin, Ulbert, Sebastian
Published in Frontiers in cellular and infection microbiology (15.11.2023)
Published in Frontiers in cellular and infection microbiology (15.11.2023)
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Low-Energy Electron Irradiation of Tick-Borne Encephalitis Virus Provides a Protective Inactivated Vaccine
Finkensieper, Julia, Issmail, Leila, Fertey, Jasmin, Rockstroh, Alexandra, Schopf, Simone, Standfest, Bastian, Thoma, Martin, Grunwald, Thomas, Ulbert, Sebastian
Published in Frontiers in immunology (07.03.2022)
Published in Frontiers in immunology (07.03.2022)
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Publisher Correction: Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities
Fertey, Jasmin, Thoma, Martin, Beckmann, Jana, Bayer, Lea, Finkensieper, Julia, Reißhauer, Susann, Berneck, Beatrice Sarah, Issmail, Leila, Schönfelder, Jessy, Casado, Javier Portillo, Poremba, Andre, Rögner, Frank-Holm, Standfest, Bastian, Makert, Gustavo R., Walcher, Lia, Kistenmacher, Ann-Kathrin, Fricke, Stephan, Grunwald, Thomas, Ulbert, Sebastian
Published in Scientific reports (23.10.2020)
Published in Scientific reports (23.10.2020)
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Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities
Fertey, Jasmin, Thoma, Martin, Beckmann, Jana, Bayer, Lea, Finkensieper, Julia, Reißhauer, Susann, Berneck, Beatrice Sarah, Issmail, Leila, Schönfelder, Jessy, Casado, Javier Portillo, Poremba, Andre, Rögner, Frank-Holm, Standfest, Bastian, Makert, Gustavo R., Walcher, Lia, Kistenmacher, Ann-Kathrin, Fricke, Stephan, Grunwald, Thomas, Ulbert, Sebastian
Published in Scientific reports (30.07.2020)
Published in Scientific reports (30.07.2020)
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Prefusion-specific antibody-derived peptides trivalently presented on DNA-nanoscaffolds as an innovative strategy against RSV entry
Issmail, Leila, Möser, Christin, Jäger, Christian, Altattan, Basma, Ramsbeck, Daniel, Kleinschmidt, Martin, Buchholz, Mirko, Smith, David, Grunwald, Thomas
Published in Frontiers in virology (online) (06.10.2022)
Published in Frontiers in virology (online) (06.10.2022)
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Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication
Stegmann, Kim M., Dickmanns, Antje, Heinen, Natalie, Blaurock, Claudia, Karrasch, Tim, Breithaupt, Angele, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Herrmann, Simon T., Schreieck, Amelie, Peelen, Evelyn, Kohlhof, Hella, Sadeghi, Balal, Riek, Alexander, Speakman, John R., Groß, Uwe, Görlich, Dirk, Vitt, Daniel, Müller, Thorsten, Grunwald, Thomas, Pfaender, Stephanie, Balkema-Buschmann, Anne, Dobbelstein, Matthias
Published in iScience (20.05.2022)
Published in iScience (20.05.2022)
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Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2
Wagner, Jannik T., Müller-Schmucker, Sandra M., Wang, Wenjun, Arnold, Philipp, Uhlig, Nadja, Issmail, Leila, Eberlein, Valentina, Damm, Dominik, Roshanbinfar, Kaveh, Ensser, Armin, Oltmanns, Friederike, Peter, Antonia Sophia, Temchura, Vladimir, Schrödel, Silke, Engel, Felix B., Thirion, Christian, Grunwald, Thomas, Wuhrer, Manfred, Grimm, Dirk, Überla, Klaus
Published in Communications biology (16.07.2024)
Published in Communications biology (16.07.2024)
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Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2
Groß, Rüdiger, Dias Loiola, Lívia Mesquita, Issmail, Leila, Uhlig, Nadja, Eberlein, Valentina, Conzelmann, Carina, Olari, Lia‐Raluca, Rauch, Lena, Lawrenz, Jan, Weil, Tatjana, Müller, Janis A., Cardoso, Mateus Borba, Gilg, Andrea, Larsson, Olivia, Höglund, Urban, Pålsson, Sandra Axberg, Tvilum, Anna Selch, Løvschall, Kaja Borup, Kristensen, Maria M., Spetz, Anna‐Lena, Hontonnou, Fortune, Galloux, Marie, Grunwald, Thomas, Zelikin, Alexander N., Münch, Jan
Published in Advanced science (01.07.2022)
Published in Advanced science (01.07.2022)
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RSV Vaccine Based on Rhabdoviral Vector Protects after Single Immunization
Wilmschen, Sarah, Schneider, Sabrina, Peters, Felix, Bayer, Lea, Issmail, Leila, Bánki, Zoltán, Grunwald, Thomas, von Laer, Dorothee, Kimpel, Janine
Published in Vaccines (Basel) (03.07.2019)
Published in Vaccines (Basel) (03.07.2019)
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Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus
Issmail, Leila, Ramsbeck, Daniel, Jäger, Christian, Henning, Tanja, Kleinschmidt, Martin, Buchholz, Mirko, Grunwald, Thomas
Published in Antiviral research (01.03.2023)
Published in Antiviral research (01.03.2023)
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Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 Activity
Gege, Christian, Hahn, Friedrich, Wangen, Christina, Häge, Sigrun, Herrmann, Alexandra, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Klopfleisch, Robert, Grunwald, Thomas, Marschall, Manfred, Kohlhof, Hella, Vitt, Daniel
Published in ChemMedChem (01.10.2024)
Published in ChemMedChem (01.10.2024)
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A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model
Peter, Antonia Sophia, Roth, Edith, Schulz, Sebastian R., Fraedrich, Kirsten, Steinmetz, Tobit, Damm, Dominik, Hauke, Manuela, Richel, Elie, Mueller‐Schmucker, Sandra, Habenicht, Katharina, Eberlein, Valentina, Issmail, Leila, Uhlig, Nadja, Dolles, Simon, Grüner, Eva, Peterhoff, David, Ciesek, Sandra, Hoffmann, Markus, Pöhlmann, Stefan, McKay, Paul F., Shattock, Robin J., Wölfel, Roman, Socher, Eileen, Wagner, Ralf, Eichler, Jutta, Sticht, Heinrich, Schuh, Wolfgang, Neipel, Frank, Ensser, Armin, Mielenz, Dirk, Tenbusch, Matthias, Winkler, Thomas H., Grunwald, Thomas, Überla, Klaus, Jäck, Hans‐Martin
Published in European journal of immunology (01.05.2022)
Published in European journal of immunology (01.05.2022)
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Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system
Reus, Philipp, Guthmann, Hadar, Uhlig, Nadja, Agbaria, Majd, Issmail, Leila, Eberlein, Valentina, Nordling-David, Mirjam M, Jbara-Agbaria, Doaa, Ciesek, Sandra, Bojkova, Denisa, Cinatl, Jindrich, Burger-Kentischer, Anke, Rupp, Steffen, Zaliani, Andrea, Grunwald, Thomas, Gribbon, Philip, Kannt, Aimo, Golomb, Gershon
Published in Journal of controlled release (01.12.2023)
Published in Journal of controlled release (01.12.2023)
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Adenoviral vector vaccines are effective mucosal booster modalities to elevate systemic and establish mucosal immunity against SARS-CoV-2
Lapuente, Dennis, Viherlehto, Vera, Fuchs, Jana, Willar, Jonas, Antao, Ana V, Eberlein, Valentina, Uhlig, Nadja, Issmail, Leila, Schmidt, Anna, Oltmanns, Friederike, Peter, Antonia Sophia, Mueller-Schmucker, Sandra, Irrgang, Pascal, Fraedrich, Kirsten, Cara, Andrea, Hoffmann, Markus, Pöhlmann, Stefan, Ensser, Armin, Pertl, Cordula, Willert, Torsten, Thirion, Christian, Grunwald, Thomas, Überla, Klaus, Tenbusch, Matthias
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity
Herrmann, Alexandra, Gege, Christian, Wangen, Christina, Wagner, Sabrina, Kögler, Melanie, Cordsmeier, Arne, Irrgang, Pascal, Ip, Wing-Hang, Weil, Tatjana, Hunszinger, Victoria, Groß, Rüdiger, Heinen, Natalie, Pfaender, Stephanie, Reuter, Sebastian, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Grunwald, Thomas, Hietel, Benjamin, Cynis, Holger, Münch, Jan, Sparrer, Konstantin M.J., Ensser, Armin, Tenbusch, Matthias, Dobner, Thomas, Vitt, Daniel, Kohlhof, Hella, Hahn, Friedrich
Published in Antiviral research (01.11.2024)
Published in Antiviral research (01.11.2024)
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Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV‑2 and Other Respiratory Viruses
Weil, Tatjana, Kirupakaran, Abbna, Le, My-Hue, Rebmann, Philipp, Mieres-Perez, Joel, Issmail, Leila, Conzelmann, Carina, Müller, Janis A., Rauch, Lena, Gilg, Andrea, Wettstein, Lukas, Groß, Rüdiger, Read, Clarissa, Bergner, Tim, Pålsson, Sandra Axberg, Uhlig, Nadja, Eberlein, Valentina, Wöll, Heike, Klärner, Frank-Gerrit, Stenger, Steffen, Kümmerer, Beate M., Streeck, Hendrik, Fois, Giorgio, Frick, Manfred, Braubach, Peter, Spetz, Anna-Lena, Grunwald, Thomas, Shorter, James, Sanchez-Garcia, Elsa, Schrader, Thomas, Münch, Jan
Published in JACS Au (26.09.2022)
Published in JACS Au (26.09.2022)
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BROAD-SPECTRUM ANTIVIRAL DRUGS
GRUNWALD, Thomas, KLEINSCHMIDT, Martin, JÄGER, Christian, ISSMAIL, Leila, RAMSBECK, Daniel, SMITH, David, MÖSER, Christin, BUCHHOLZ, Mirko
Year of Publication 15.05.2024
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Year of Publication 15.05.2024
Patent
BROAD-SPECTRUM ANTIVIRAL DRUGS
GRUNWALD, Thomas, KLEINSCHMIDT, Martin, JÄGER, Christian, ISSMAIL, Leila, RAMSBECK, Daniel, SMITH, David, MÖSER, Christin, BUCHHOLZ, Mirko
Year of Publication 12.01.2023
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Year of Publication 12.01.2023
Patent