Search Results - "ISOBE Yoshiaki" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structural analysis reveals TLR7 dynamics underlying antagonism

Structural analysis reveals TLR7 dynamics underlying antagonism

by Tojo, Shingo, Zhang, Zhikuan, Matsui, Hiroyuki, Tahara, Masahiro, Ikeguchi, Mitsunori, Kochi, Mami, Kamada, Mami, Shigematsu, Hideki, Tsutsumi, Akihisa, Adachi, Naruhiko, Shibata, Takuma, Yamamoto, Masaki, Kikkawa, Masahide, Senda, Toshiya, Isobe, Yoshiaki, Ohto, Umeharu, Shimizu, Toshiyuki
Published in Nature communications (15.10.2020)

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Journal Article

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

by Tojo, Shingo, Kohno, Tetsuya, Tanaka, Tomoyuki, Kamioka, Seiji, Ota, Yosuke, Ishii, Takayuki, Kamimoto, Keiko, Asano, Shigehiro, Isobe, Yoshiaki
Published in ACS medicinal chemistry letters (09.10.2014)

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Journal Article

Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase

Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase

by Isobe, Yoshiaki, Hida, Hideki, Nishino, Hitoo
Published in Journal of neuroscience research (01.06.2011)

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Journal Article

Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases

Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases

by Tobe, Masanori, Tsuboi, Katsunori, Hasegawa, Futoshi, Fujiwara, Norio, Inoue, Yoshifumi, Isobe, Masakazu, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (15.02.2016)

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Journal Article

Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept

Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept

by Kurimoto, Ayumu, Hashimoto, Kazuki, Nakamura, Tomoaki, Norimura, Kei, Ogita, Haruhisa, Takaku, Haruo, Bonnert, Roger, McInally, Tom, Wada, Hiroki, Isobe, Yoshiaki
Published in Journal of medicinal chemistry (08.04.2010)

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Journal Article

Synthesis of Novel Benzo-Fused Heteroaryl Derivatives as Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitors

Synthesis of Novel Benzo-Fused Heteroaryl Derivatives as Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitors

by Komiya, Masafumi, Asano, Shigehiro, Koike, Nobuyuki, Koga, Erina, Igarashi, Junetsu, Nakatani, Shogo, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (2013)

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Journal Article

Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

by ISOBE, Yoshiaki, TOBE, Masanori, INOUE, Yoshifumi, ISOBE, Masakazu, TSUCHIYA, Masami, HAYASHI, Hideya
Published in Bioorganic & medicinal chemistry (17.11.2003)

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Journal Article

CONTROL DEVICE OF ELECTRIC WINCH

CONTROL DEVICE OF ELECTRIC WINCH

by ISOBE YOSHIAKI
Year of Publication 21.11.2019

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Patent

VEHICULAR OPENING/CLOSING BODY CONTROL DEVICE

VEHICULAR OPENING/CLOSING BODY CONTROL DEVICE

by ISOBE Yoshiaki
Year of Publication 14.11.2019

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Patent

DATA CONTROL SYSTEM AND DATA CONTROL METHOD

DATA CONTROL SYSTEM AND DATA CONTROL METHOD

by TAMURA HISASHI, ISOBE YOSHIAKI
Year of Publication 04.07.2022

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Patent

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e] [1,4]diazepines with clozapine-like receptor occupancy at dopamine D-1/D-2 receptor

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e] [1,4]diazepines with clozapine-like receptor occupancy at dopamine D-1/D-2 receptor

by Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Horiguchi, Masakuni, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.11.2020)

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Journal Article

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor

Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor

by Watanabe, Hitoshi, Ishida, Kyoji, Yamamoto, Masanori, Horiguchi, Masakuni, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.11.2020)

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Journal Article

Synthesis of Pyrimidine Derivatives Possessing an Antioxidative Property and Their Inhibitory Effects on Picryl Chloride-Induced Contact Hypersensitivity Reaction

Synthesis of Pyrimidine Derivatives Possessing an Antioxidative Property and Their Inhibitory Effects on Picryl Chloride-Induced Contact Hypersensitivity Reaction

by Isobe, Yoshiaki, Hirota, Kosaku
Published in Chemical & pharmaceutical bulletin (01.12.2003)

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Journal Article

BUSINESS RISK ANALYSIS SYSTEM AND BUSINESS RISK ANALYSIS METHOD

BUSINESS RISK ANALYSIS SYSTEM AND BUSINESS RISK ANALYSIS METHOD

by NAKAKOJI HIROSHI, KUMAGAI YOKO, ISOBE YOSHIAKI
Year of Publication 02.04.2024

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Patent

Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release

Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release

by Isobe, Yoshiaki, Fujioi, Junko, Nishino, Hitoo
Published in Brain research (09.11.2001)

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Journal Article

Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor

Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor

by Tsuboi, Katsunori, Kimura, Hidenori, Nakatsuji, Yoshie, Kassai, Momoe, Deai, Yoko, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (15.07.2021)

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Journal Article

N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors

N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors

by Kimura, Hidenori, Suda, Hitoshi, Kassai, Momoe, Endo, Mika, Deai, Yoko, Yahata, Masahiro, Miyajima, Mari, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.02.2021)

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Journal Article

Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: Potent Interferon Inducing Agents in Monkeys

Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: Potent Interferon Inducing Agents in Monkeys

by Kurimoto, Ayumu, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Takaku, Haruo, Ichii, Shinji, Kawakami, Hajime, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.04.2004)

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Journal Article

PHARMACEUTICAL COMPOSITION CONTAINING OXADIAZOLE DERIVATIVE

PHARMACEUTICAL COMPOSITION CONTAINING OXADIAZOLE DERIVATIVE

by MIYAJI HIROTAKA, TANAKA TOMOYUKI, ISOBE YOSHIAKI
Year of Publication 03.04.2023

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Patent

DAMAGE PREDICTION METHOD, DAMAGE PREDICTION SYSTEM, AND PROGRAM

DAMAGE PREDICTION METHOD, DAMAGE PREDICTION SYSTEM, AND PROGRAM

by NAKAHATA MASAYA, ISOBE YOSHIAKI
Year of Publication 12.12.2019

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Patent

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