Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction
Yahata, Kenzo, Ye, Ning, Ai, Yanran, Iso, Kentaro, Kishi, Yoshito
Published in Angewandte Chemie International Edition (28.08.2017)
Published in Angewandte Chemie International Edition (28.08.2017)
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Delivery of a BET protein degrader via a CEACAM6-targeted antibody–drug conjugate inhibits tumour growth in pancreatic cancer models
Nakazawa, Youya, Miyano, Masayuki, Tsukamoto, Shuntaro, Kogai, Hiroyuki, Yamamoto, Akihiko, Iso, Kentaro, Inoue, Satoshi, Yamane, Yoshinobu, Yabe, Yuki, Umihara, Hirotatsu, Taguchi, Junichi, Akagi, Tsuyoshi, Yamaguchi, Atsumi, Koga, Minaho, Toshimitsu, Kohta, Hirayama, Toshifumi, Mukai, Yohei, Machinaga, Akihito
Published in Nature communications (11.03.2024)
Published in Nature communications (11.03.2024)
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A landmark in drug discovery based on complex natural product synthesis
Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Scientific reports (17.06.2019)
Published in Scientific reports (17.06.2019)
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Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A
Yamashita, Shuji, Kitajima, Kazuki, Iso, Kentaro, Hirama, Masahiro
Published in Tetrahedron letters (01.07.2009)
Published in Tetrahedron letters (01.07.2009)
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Synthesis of the bicyclo[7.3.0]dodecadiyne core of the maduropeptin chromophore
Iso, Kentaro, Inoue, Masayuki, Kato, Nobuki, Hirama, Masahiro
Published in Chemistry, an Asian journal (01.02.2008)
Published in Chemistry, an Asian journal (01.02.2008)
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Journal Article
Total Synthesis of Cortistatins A and J
Yamashita, Shuji, Iso, Kentaro, Kitajima, Kazuki, Himuro, Masafumi, Hirama, Masahiro
Published in Journal of organic chemistry (15.04.2011)
Published in Journal of organic chemistry (15.04.2011)
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Targeted protein degradation via intramolecular bivalent glues
Hsia, Oliver, Hinterndorfer, Matthias, Cowan, Angus D., Iso, Kentaro, Ishida, Tasuku, Sundaramoorthy, Ramasubramanian, Nakasone, Mark A., Imrichova, Hana, Schätz, Caroline, Rukavina, Andrea, Husnjak, Koraljka, Wegner, Martin, Correa-Sáez, Alejandro, Craigon, Conner, Casement, Ryan, Maniaci, Chiara, Testa, Andrea, Kaulich, Manuel, Dikic, Ivan, Winter, Georg E., Ciulli, Alessio
Published in Nature (London) (07.03.2024)
Published in Nature (London) (07.03.2024)
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Journal Article
Stereocontrolled Synthesis of Left Halves of Halichondrins
Yahata, Kenzo, Ye, Ning, Iso, Kentaro, Ai, Yanran, Lee, Jihoon, Kishi, Yoshito
Published in Journal of organic chemistry (01.09.2017)
Published in Journal of organic chemistry (01.09.2017)
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Journal Article
E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Yamada, Kazuhiko, Hori, Yusaku, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Kamiyama, Hiroshi, Yamaguchi, Atsumi, Kimura, Takayuki, Uesugi, Mai, Ito, Junichi, Matsuki, Masahiro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Kushida, Ikuo, Wakayama, Naomi, Kubara, Kenji, Kato, Yu, Semba, Taro, Yokoi, Akira, Matsukura, Masayuki, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi, Funahashi, Yasuhiro, Ozawa, Yoichi
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Journal Article
Unified Synthesis of Right Halves of Halichondrins A–C
Yahata, Kenzo, Ye, Ning, Iso, Kentaro, Naini, Santhosh Reddy, Yamashita, Shuji, Ai, Yanran, Kishi, Yoshito
Published in Journal of organic chemistry (01.09.2017)
Published in Journal of organic chemistry (01.09.2017)
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Journal Article
Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials
Kaburagi, Yosuke, Kira, Kazunobu, Yahata, Kenzo, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Matsuda, Masaaki, Matsukura, Masayuki, Murai, Norio, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Watanabe, Yuzo, Kamada, Atsushi, Kayano, Akio, Tagami, Katsuya, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Organic letters (12.04.2024)
Published in Organic letters (12.04.2024)
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Journal Article
What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study
Sasaki, Takeo, Yahata, Kenzo, Isomura, Minetaka, Ohashi, Isao, Fukuyama, Takashi, Miyashita, Yusuke, Watanabe, Yuzo, Murai, Norio, Matsuda, Masaaki, Kamada, Atsushi, Kaburagi, Yosuke, Kira, Kazunobu, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Matsumoto, Yasunobu, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Matsukura, Masayuki, Asano, Osamu, Kayano, Akio, Tagami, Katsuya, Owa, Takashi, Kishi, Yoshito
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
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Journal Article
Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator
Kawano, Satoshi, Abe, Takanori, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator
Abe, Takanori, Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
SYNTHESIS OF HALICHONDRINS
KISHI YOSHITO, ISO KENTARO, LEE JIHOON, FUKUYAMA TAKASHI, AI YANRAN, SANTHOSH REDDY NAINI, HACHIMAN KENZO, YE NING, YAMASHITA SHUJI, WANG QIAOYI, OHASHI ISAO
Year of Publication 21.11.2023
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Year of Publication 21.11.2023
Patent
ANTIBODY-DRUG COMPLEX
MUKAI Yohei, KATO Masaki, UMIHARA Hirotatsu, HIRAYAMA Toshifumi, MOCHIZUKI Toshiki, INOUE Satoshi, YAMAGUCHI Atsumi, MIYANO Masayuki, YAMAMOTO Yuji, ISO Kentaro, TAGUCHI Junichi, KOGAI Hiroyuki, AKAGI Tsuyoshi, YABE Yuki, SAKURADA Takato, NAKAZAWA Yuya, YAMAMOTO Akihiko, TSUKAMOTO Shuntaro
Year of Publication 29.02.2024
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Year of Publication 29.02.2024
Patent