Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment
Toyama, Kaoru, Kiyosawa, Naoki, Watanabe, Kenji, Ishizuka, Hitoshi
Published in International journal of molecular sciences (16.09.2017)
Published in International journal of molecular sciences (16.09.2017)
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Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects
Kato, Manabu, Furuie, Hidetoshi, Shimizu, Takako, Miyazaki, Atsuhiro, Kobayashi, Fumiaki, Ishizuka, Hitoshi
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment
Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi
Published in European journal of clinical pharmacology (01.01.2022)
Published in European journal of clinical pharmacology (01.01.2022)
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Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment
Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi
Published in European journal of clinical pharmacology (2022)
Published in European journal of clinical pharmacology (2022)
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Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects
Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in British journal of clinical pharmacology (01.10.2020)
Published in British journal of clinical pharmacology (01.10.2020)
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Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers
Ishizuka, Hitoshi, Yoshiba, Satoshi, Okabe, Hiromi, Yoshihara, Kazutaka
Published in Journal of clinical pharmacology (01.11.2010)
Published in Journal of clinical pharmacology (01.11.2010)
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Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects
Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi
Published in Clinical and translational science (01.11.2023)
Published in Clinical and translational science (01.11.2023)
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Intrapulmonary Distribution and Pharmacokinetics of Laninamivir, a Neuraminidase Inhibitor, after a Single Inhaled Administration of Its Prodrug, Laninamivir Octanoate, in Healthy Volunteers
ISHIZUKA, Hitoshi, TOYAMA, Kaoru, YOSHIBA, Satoshi, OKABE, Hiromi, FURUIE, Hidetoshi
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
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Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan
Hong, Ying, Ishizuka, Tomoko, Watanabe, Akiko, Tachibana, Masaya, Lee, Mark, Ishizuka, Hitoshi, LaCreta, Frank, Abutarif, Malaz
Published in Clinical and translational science (01.11.2021)
Published in Clinical and translational science (01.11.2021)
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Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
Kurata, Akifumi, Furuie, Hidetoshi, Ishizuka, Tomoko, Nakatsu, Takafumi, Shimizu, Takako, Kato, Manabu, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in Advances in therapy (01.07.2019)
Published in Advances in therapy (01.07.2019)
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A Randomized, Placebo‐Controlled, Double‐Blind Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Doses of Mirogabalin in Healthy Asian Volunteers
Jansen, Mendel, Warrington, Steven, Dishy, Victor, Ohwada, Shoichi, Johnson, Lisa, Brown, Karen, Ishizuka, Hitoshi
Published in Clinical pharmacology in drug development (01.08.2018)
Published in Clinical pharmacology in drug development (01.08.2018)
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Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in BMC pharmacology & toxicology (29.07.2020)
Published in BMC pharmacology & toxicology (29.07.2020)
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Assessment of the effects of renal impairment on the pharmacokinetic profile of laninamivir, a novel neuraminidase inhibitor, after a single inhaled dose of its Prodrug, CS-8958
Ishizuka, Hitoshi, Yoshiba, Satoshi, Yoshihara, Kazutaka, Okabe, Hiromi
Published in Journal of clinical pharmacology (01.02.2011)
Published in Journal of clinical pharmacology (01.02.2011)
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Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection
Yoshihara, Kazutaka, Ishizuka, Hitoshi, Kubo, Yuichi
Published in Drug metabolism and pharmacokinetics (2013)
Published in Drug metabolism and pharmacokinetics (2013)
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Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure
Endo, Seiko, Fukahori, Aiko, Tokuhiro, Shinya, Shinagawa, Akira, Walker, Joseph, Yoshihara, Kazutaka, Ishizuka, Hitoshi, Ieiri, Ichiro, Sugiyama, Yuichi
Published in Journal of human genetics (01.08.2012)
Published in Journal of human genetics (01.08.2012)
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Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection
Kazutaka YOSHIHARA, Hitoshi ISHIZUKA, Yuichi KUBO
Published in DRUG METABOLISM AND PHARMACOKINETICS (25.10.2013)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (25.10.2013)
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Pharmacokinetics/Pharmacodynamics Analysis of the Relationship between the in Vivo Micturition Pressure and Receptor Occupancy of (R)-Oxybutynin and Its Metabolite in Rats
Mizushima, Haruhi, Kinoshita, Kazuya, Abe, Koji, Ishizuka, Hitoshi, Yamada, Yasuhiko
Published in Biological & Pharmaceutical Bulletin (01.05.2007)
Published in Biological & Pharmaceutical Bulletin (01.05.2007)
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