Synergistic inhibition by BQ‐123 and BQ‐788 of endothelin‐1‐induced contractions of the rabbit pulmonary artery
Fukuroda, Takahiro, Ozaki, Satoshi, Ihara, Masaki, Ishikawa, Kiyofumi, Yano, Mitsuo, Nishikibe, Masaru
Published in British journal of pharmacology (01.10.1994)
Published in British journal of pharmacology (01.10.1994)
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Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala 1,3,11,15]ET-1
Nakamichi, Kyoko, Ihara, Masaki, Kobayashi, Masahiko, Saeki, Toshihiko, Ishikawa, Kiyofumi, Yano, Mitsuo
Published in Biochemical and biophysical research communications (15.01.1992)
Published in Biochemical and biophysical research communications (15.01.1992)
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Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin‐1‐induced contraction in human bronchi
Fukuroda, Takahiro, Ozaki, Satoshi, Ihara, Masaki, Ishikawa, Kiyofumi, Yano, Mitsuo, Miyauchi, Takashi, Ishikawa, Shigemi, Onizuka, Masataka, Goto, Katsutoshi, Nishikibe, Masaru
Published in British journal of pharmacology (01.03.1996)
Published in British journal of pharmacology (01.03.1996)
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Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model
Nishikibe, Masaru, Tsuchida, Sonoko, Okada, Megumu, Fukuroda, Takahiro, Shimamoto, Koji, Yano, Mitsuo, Ishikawa, Kiyofumi, Ikemoto, Fumihiko
Published in Life sciences (1973) (1993)
Published in Life sciences (1973) (1993)
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Synthesis and Structure−Activity Relationships of 2-Substituted d-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of the d-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity
Fukami, Takehiro, Yamakawa, Takeru, Niiyama, Kenji, Kojima, Hisaki, Amano, Yuuka, Kanda, Fuyuko, Ozaki, Satoshi, Fukuroda, Takahiro, Ihara, Masaki, Yano, Mitsuo, Ishikawa, Kiyofumi
Published in Journal of medicinal chemistry (07.06.1996)
Published in Journal of medicinal chemistry (07.06.1996)
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Rate and Equilibrium Constants for the Epimerization of the Endothelin Receptor Antagonist J-104, 132 in Aqueous Solution
BRAY, Michelle L., GORBACHEVA, Daniela, JAHANSOUZ, Hossain, KAUFMAN, Michael J., ISHIKAWA, Kiyofumi, HARADA, Nobuo, SUZUKI, Kimimasa
Published in Chemical & pharmaceutical bulletin (2001)
Published in Chemical & pharmaceutical bulletin (2001)
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[3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype
IHARA, M, YAMANAKA, R, OHWAKI, K, OZAKI, S, FUKAMI, T, ISHIKAWA, K, TOWERS, P, YANO, M
Published in European journal of pharmacology (14.02.1995)
Published in European journal of pharmacology (14.02.1995)
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Coexpression Studies with Endothelin Receptor Subtypes Indicate the Existence of Intracellular Cross-Talk between ETA and ETB Receptors
Ozaki, Satoshi, Ohwaki, Kenji, Ihara, Masaki, Ishikawa, Kiyofumi, Yano, Mitsuo
Published in Journal of biochemistry (Tokyo) (01.03.1997)
Published in Journal of biochemistry (Tokyo) (01.03.1997)
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Cyclic Pentapeptide Endothelin A Receptor Antagonists with Attenuated in Vivo Clearance
FUKAMI, Takehiro, NIIYAMA, Kenji, AMANO, Yuuka, HISAKA, Akihiro, FUJINO, Naoko, SAWASAKI, Yoshio, IHARA, Masaki, ISHIKAWA, Kiyofumi
Published in Chemical & pharmaceutical bulletin (01.03.1996)
Published in Chemical & pharmaceutical bulletin (01.03.1996)
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Application of the tetrabutylammonium salt of an amino acid for liquid phase peptide synthesis: An easy way to prepare endothelin antagonistic linear peptides via an azide method
Nagase, Toshio, Fukami, Takehiro, Urakawa, Yuko, Kumagai, Uno, Ishikawa, Kiyofumi
Published in Tetrahedron letters (09.04.1993)
Published in Tetrahedron letters (09.04.1993)
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Suppressive effects of the endothelin receptor (ETA) antagonist BQ-123 on ET-1-induced reduction of lipoprotein lipase activity in 3T3-L1 adipocytes
Ishida, F, Saeki, K, Saeki, T, Ishikawa, K, Ihara, M, Kamei, T, Yano, M
Published in Biochemical pharmacology (06.10.1992)
Published in Biochemical pharmacology (06.10.1992)
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Clearance of circulating endothelin-1 by ETB receptors in rats
FUKURODA, T, FUJIKAWA, T, OZAKI, S, ISHIKAWA, K, YANO, M, NISHIKIBE, M
Published in Biochemical and biophysical research communications (30.03.1994)
Published in Biochemical and biophysical research communications (30.03.1994)
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Biochemical and Pharmacological Profile of a Potent and Selective Endothelin B-Receptor Antagonist, BQ-788
Ishikawa, Kiyofumi, Ihara, Masaki, Noguchi, Kazuhito, Mase, Toshiaki, Mino, Nobuyuki, Saeki, Toshihiko, Fukuroda, Takahiro, Fukami, Takehiro, Ozaki, Satoshi, Nagase, Toshio, Nishikibe, Masaru, Yano, Mitsuo
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.1994)
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In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor
Ihara, M, Ishikawa, K, Fukuroda, T, Saeki, T, Funabashi, K, Fukami, T, Suda, H, Yano, M
Published in Journal of cardiovascular pharmacology (01.04.1992)
Published in Journal of cardiovascular pharmacology (01.04.1992)
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6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridine derivatives: A novel class of endothelin receptor antagonists
NIIYAMA, Kenji, MASE, Toshiaki, IHARA, Masaki, YANO, Mitsuo, FUKURODA, Takahiro, NOGUCHI, Kazuhito, NISHIKIBE, Masaru, ISHIKAWA, Kiyofumi, TAKAHASHI, Hirobumi, NAYA, Akira, KATSUKI, Kasumi, NAGASE, Toshio, ITO, Satoshi, HAYAMA, Takashi, HISAKA, Akihiro, OZAKI, Satoshi
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications
Ishikawa, Kiyofumi, Fukami, Takehiro, Nagase, Toshio, Fujita, Kagari, Hayama, Takashi, Niiyama, Kenji, Mase, Toshiaki, Ihara, Masaki, Yano, Mitsuo
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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