Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
Lito, Piro, Saborowski, Anna, Yue, Jingyin, Solomon, Martha, Joseph, Eric, Gadal, Sunyana, Saborowski, Michael, Kastenhuber, Edward, Fellmann, Christof, Ohara, Kazuhiro, Morikami, Kenji, Miura, Takaaki, Lukacs, Christine, Ishii, Nobuya, Lowe, Scott, Rosen, Neal
Published in Cancer cell (12.05.2014)
Published in Cancer cell (12.05.2014)
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CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko
Published in Cancer cell (17.05.2011)
Published in Cancer cell (17.05.2011)
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Inhibition of metastasis of rhabdomyosarcoma by a novel neutralizing antibody to CXC chemokine receptor‐4
Kashima, Kenji, Watanabe, Miho, Sato, Yasuko, Hata, Junichi, Ishii, Nobuya, Aoki, Yuko
Published in Cancer science (01.10.2014)
Published in Cancer science (01.10.2014)
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Journal Article
ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor
Nakanishi, Yoshito, Mizuno, Hideaki, Sase, Hitoshi, Fujii, Toshihiko, Sakata, Kiyoaki, Akiyama, Nukinori, Aoki, Yuko, Aoki, Masahiro, Ishii, Nobuya
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells
OKAMOTO, Aikou, NIKAIDO, Takashi, KAWAGUCHI, Rie, ISONISHI, Seiji, TANAKA, Tadao, URASHIMA, Mitsuyoshi, OCHIAI, Kazunori, TAKAKURA, Satoshi, SAITO, Misato, AOKI, Yuko, ISHII, Nobuya, YANAIHARA, Nozomu, YAMADA, Kyosuke, TAKIKAWA, Osamu
Published in Clinical cancer research (15.08.2005)
Published in Clinical cancer research (15.08.2005)
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Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma
Okamoto, Aikou, Sehouli, Jalid, Yanaihara, Nozomu, Hirata, Yukihiro, Braicu, Ioana, Kim, Byoung-Gie, Takakura, Satoshi, Saito, Misato, Yanagida, Satoshi, Takenaka, Masataka, Yamaguchi, Noriko, Morikawa, Asuka, Tanabe, Hiroshi, Yamada, Kyosuke, Yoshihara, Kosuke, Enomoto, Takayuki, Itamochi, Hiroaki, Kigawa, Junzo, Matsumura, Noriomi, Konishi, Ikuo, Aida, Satoshi, Aoki, Yuko, Ishii, Nobuya, Ochiai, Kazunori, Akiyama, Tetsu, Urashima, Mitsuyoshi
Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non‐small‐cell lung cancer
Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko
Published in Cancer science (01.10.2013)
Published in Cancer science (01.10.2013)
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A signature-based method for indexing cell cycle phase distribution from microarray profiles
Mizuno, Hideaki, Nakanishi, Yoshito, Ishii, Nobuya, Sarai, Akinori, Kitada, Kunio
Published in BMC genomics (30.03.2009)
Published in BMC genomics (30.03.2009)
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Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers
Ono, Naomi, Yamazaki, Toshikazu, Nakanishi, Yoshito, Fujii, Toshihiko, Sakata, Kiyoaki, Tachibana, Yukako, Suda, Atsushi, Hada, Kihito, Miura, Takaaki, Sato, Shigeo, Saitoh, Ryoichi, Nakano, Kohnosuke, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko
Published in Cancer science (01.02.2012)
Published in Cancer science (01.02.2012)
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Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors
Asoh, Kohsuke, Kohchi, Masami, Hyoudoh, Ikumi, Ohtsuka, Tatsuo, Masubuchi, Miyako, Kawasaki, Kenichi, Ebiike, Hirosato, Shiratori, Yasuhiko, Fukami, Takaaki A., Kondoh, Osamu, Tsukaguchi, Toshiyuki, Ishii, Nobuya, Aoki, Yuko, Shimma, Nobuo, Sakaitani, Masahiro
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker
LEE, Lucy, HUIFENG NIU, GOELZER, Petra, DE SCHEPPER, Stefanie, YOSHIMURA, Yashushi, BARRETT, Joanne, ISHIKAWA, Yuji, WEISSGERBER, Georges, PECK, Richard, RUEGER, Ruediger, IGAWA, Yuriko, DEUTSCH, Jonathan, ISHII, Nobuya, SONG MU, SAKAMOTO, Yuuichiro, BUSSE-REID, Rachel, GIMMI, Claude
Published in Clinical cancer research (01.12.2009)
Published in Clinical cancer research (01.12.2009)
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Journal Article
The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Sase, Hitoshi, Isobe, Takehito, Morikami, Kenji, Shindoh, Hidetoshi, Mio, Toshiyuki, Ebiike, Hirosato, Taka, Naoki, Aoki, Yuko, Ishii, Nobuya
Published in Molecular cancer therapeutics (01.11.2014)
Published in Molecular cancer therapeutics (01.11.2014)
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A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations
Voss, Martin H, Hierro, Cinta, Heist, Rebecca S, Cleary, James M, Meric-Bernstam, Funda, Tabernero, Josep, Janku, Filip, Gandhi, Leena, Iafrate, A John, Borger, Darrell R, Ishii, Nobuya, Hu, Youyou, Kirpicheva, Yulia, Nicolas-Metral, Valerie, Pokorska-Bocci, Anna, Vaslin Chessex, Anne, Zanna, Claudio, Flaherty, Keith T, Baselga, Jose
Published in Clinical cancer research (01.05.2019)
Published in Clinical cancer research (01.05.2019)
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Journal Article
YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification
Hamanaka, Natsuki, Nakanishi, Yoshito, Mizuno, Takakazu, Horiguchi-Takei, Kana, Akiyama, Nukinori, Tanimura, Hiromi, Hasegawa, Masami, Satoh, Yasuko, Tachibana, Yukako, Fujii, Toshihiko, Sakata, Kiyoaki, Ogasawara, Kiyomoto, Ebiike, Hirosato, Koyano, Hiroshi, Sato, Haruhiko, Ishii, Nobuya, Mio, Toshiyuki
Published in Cancer research (Chicago, Ill.) (15.11.2019)
Published in Cancer research (Chicago, Ill.) (15.11.2019)
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Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine
Nagarajah, James, Le, Mina, Knauf, Jeffrey A, Ferrandino, Giuseppe, Montero-Conde, Cristina, Pillarsetty, Nagavarakishore, Bolaender, Alexander, Irwin, Christopher, Krishnamoorthy, Gnana Prakasam, Saqcena, Mahesh, Larson, Steven M, Ho, Alan L, Seshan, Venkatraman, Ishii, Nobuya, Carrasco, Nancy, Rosen, Neal, Weber, Wolfgang A, Fagin, James A
Published in The Journal of clinical investigation (01.11.2016)
Published in The Journal of clinical investigation (01.11.2016)
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Journal Article
Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
ISHII, Nobuya, HARADA, Naoki, AOKI, Toshihiro, SHIMMA, Nobuo, ARISAWA, Mikio, SOWA, Yoshihiro, POULIKAKOS, Poulikos I, ROSEN, Neal, AOKI, Yuko, SAKAI, Toshiyuki, JOSEPH, Eric W, OHARA, Kazuhiro, MIURA, Takaaki, SAKAMOTO, Hiroshi, MATSUDA, Yutaka, TOMII, Yasushi, TACHIBANA-KONDO, Yukako, LIKURA, Hitoshi
Published in Cancer research (Chicago, Ill.) (01.07.2013)
Published in Cancer research (Chicago, Ill.) (01.07.2013)
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Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2 -Amplified Gastric Cancer
Sase, Hitoshi, Nakanishi, Yoshito, Aida, Satoshi, Horiguchi-Takei, Kana, Akiyama, Nukinori, Fujii, Toshihiko, Sakata, Kiyoaki, Mio, Toshiyuki, Aoki, Masahiro, Ishii, Nobuya
Published in Molecular cancer therapeutics (01.10.2018)
Published in Molecular cancer therapeutics (01.10.2018)
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