Broad spectrum and potent antitumor activities of YM155, a novel small‐molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
Nakahara, Takahito, Kita, Aya, Yamanaka, Kentaro, Mori, Masamichi, Amino, Nobuaki, Takeuchi, Masahiro, Tominaga, Fumiko, Kinoyama, Isao, Matsuhisa, Akira, Kudou, Masafumi, Sasamata, Masao
Published in Cancer science (01.03.2011)
Published in Cancer science (01.03.2011)
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Journal Article
YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts
NAKAHARA, Takahito, TAKEUCHI, Masahiro, SASAMATA, Masao, KINOYAMA, Isao, MINEMATSU, Tsuyoshi, SHIRASUNA, Kenna, MATSUHISA, Akira, KITA, Aya, TOMINAGA, Fumiko, YAMANAKA, Kentaro, KUDOH, Masafumi
Published in Cancer research (Chicago, Ill.) (01.09.2007)
Published in Cancer research (Chicago, Ill.) (01.09.2007)
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Journal Article
Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin
Nakamura, Naoto, Yamauchi, Tomohiro, Hiramoto, Masashi, Yuri, Masatoshi, Naito, Masanori, Takeuchi, Masahiro, Yamanaka, Kentaro, Kita, Aya, Nakahara, Takahito, Kinoyama, Isao, Matsuhisa, Akira, Kaneko, Naoki, Koutoku, Hiroshi, Sasamata, Masao, Yokota, Hiroyuki, Kawabata, Shigeki, Furuichi, Kiyoshi
Published in Molecular & cellular proteomics (01.07.2012)
Published in Molecular & cellular proteomics (01.07.2012)
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Journal Article
Sepantronium Bromide (YM155) induces disruption of the ILF3/p54nrb complex, which is required for survivin expression
Yamauchi, Tomohiro, Nakamura, Naoto, Hiramoto, Masashi, Yuri, Masatoshi, Yokota, Hiroyuki, Naitou, Masanori, Takeuchi, Masahiro, Yamanaka, Kentaro, Kita, Aya, Nakahara, Takahito, Kinoyama, Isao, Matsuhisa, Akira, Kaneko, Naoki, Koutoku, Hiroshi, Sasamata, Masao, Kobori, Masato, Katou, Masao, Tawara, Shuichi, Kawabata, Shigeki, Furuichi, Kiyoshi
Published in Biochemical and biophysical research communications (01.09.2012)
Published in Biochemical and biophysical research communications (01.09.2012)
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Journal Article
N-Arylpiperazine-1-carboxamide Derivatives: a Novel Series of Orally Active Nonsteroidal Androgen Receptor Antagonists
Kinoyama, Isao, Taniguchi, Nobuaki, Kawaminami, Eiji, Nozawa, Eisuke, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru
Published in Chemical & Pharmaceutical Bulletin (2005)
Published in Chemical & Pharmaceutical Bulletin (2005)
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Journal Article
Synthesis and Pharmacological Evaluation of Novel Arylpiperazine Derivatives as Nonsteroidal Androgen Receptor Antagonists
Kinoyama, Isao, Taniguchi, Nobuaki, Yoden, Toru, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru
Published in Chemical & Pharmaceutical Bulletin (01.11.2004)
Published in Chemical & Pharmaceutical Bulletin (01.11.2004)
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Journal Article
S2G-18-2 YM155： a small molecule survivin suppressant with potent antitumor effect in human cancer xenograft models
Aya Kita, Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama, Akira Matsuhisa, Kentaro Yamanaka, Mari Nakata, Naoki Kaneko, Hiroshi Koutoku, Masao Sasamata
Published in Journal of Pharmacological Sciences (2010)
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Published in Journal of Pharmacological Sciences (2010)
Journal Article
Sepantronium bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin expression
Yamauchi, Tomohiro, Nakamura, Naoto, Hiramoto, Masashi, Yuri, Masatoshi, Yokota, Hiroyuki, Naitou, Masanori, Takeuchi, Masahiro, Yamanaka, Kentaro, Kita, Aya, Nakahara, Takahito, Kinoyama, Isao, Matsuhisa, Akira, Kaneko, Naoki, Koutoku, Hiroshi, Sasamata, Masao, Kobori, Masato, Katou, Masao, Tawara, Shuichi, Kawabata, Shigeki, Furuichi, Kiyoshi
Published in Biochemical and biophysical research communications (07.09.2012)
Published in Biochemical and biophysical research communications (07.09.2012)
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Journal Article
Synthesis and Biological Evaluation of 1, 2, 3, 4-Tetrahydroisoquinoline Derivatives as Potent and Selective M2 Muscarinic Receptor Antagonists
WATANABE, Toshihiro, KINOYAMA, Isao, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBANUMA, Tadao
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Journal Article
YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model
Nakahara, Takahito, Yamanaka, Kentaro, Hatakeyama, Shinji, Kita, Aya, Takeuchi, Masahiro, Kinoyama, Isao, Matsuhisa, Akira, Nakano, Kenji, Shishido, Takao, Koutoku, Hiroshi, Sasamata, Masao
Published in Anti-cancer drugs (01.06.2011)
Published in Anti-cancer drugs (01.06.2011)
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Journal Article
Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization
Zakhari, Joseph S., Kinoyama, Isao, Hixon, Mark S., Di Mola, Antonia, Globisch, Daniel, Janda, Kim D.
Published in Bioorganic & medicinal chemistry (01.11.2011)
Published in Bioorganic & medicinal chemistry (01.11.2011)
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Journal Article
Synthesis of Novel Succinamide Derivatives Having the 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. I
WATANABE, Toshihiro, KINOYAMA, Isao, KAKEFUDA, Akio, OKAZAKI, Toshio, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBATA, Hiroshi, YANAGISAWA, Isao
Published in Chemical & pharmaceutical bulletin (1997)
Published in Chemical & pharmaceutical bulletin (1997)
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Journal Article
Synthesis of Novel Succinamide Derivatives Having a 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. II
WATANABE, Toshihiro, KAKEFUDA, Akio, KINOYAMA, Isao, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBATA, Hiroshi, YANAGISAWA, Isao
Published in Chemical & pharmaceutical bulletin (1997)
Published in Chemical & pharmaceutical bulletin (1997)
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Journal Article
Synthesis and Molecular Modeling Provide Insight into a Pseudomonas aeruginosa Quorum Sensing Conundrum
Zakhari, Joseph S, Kinoyama, Isao, Struss, Anjali K, Pullanikat, Prasanna, Lowery, Colin A, Lardy, Matthew, Janda, Kim D
Published in Journal of the American Chemical Society (23.03.2011)
Published in Journal of the American Chemical Society (23.03.2011)
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Journal Article
Abstract 4756: YM155 suppresses survivin expression by disrupting the ILF3/p54nrb transcription factor complex
Nakamura, Naoto, Yamauchi, Tomohiro, Hiramoto, Masashi, Yuri, Masatoshi, Naito, Masanori, Takeuchi, Masahiro, Yamanaka, Kentaro, Nakahara, Takahito, Kita, Aya, Kinoyama, Isao, Matsuhisa, Akira, Sasamata, Masao, Yokota, Hiroyuki, Kawabata, Shigeki, Furuichi, Kiyoshi
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist
Kinoyama, Isao, Taniguchi, Nobuaki, Toyoshima, Akira, Nozawa, Eisuke, Kamikubo, Takashi, Imamura, Masakazu, Matsuhisa, Akira, Samizu, Kiyohiro, Kawanimani, Eiji, Niimi, Tatsuya, Hamada, Noritaka, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Journal Article
Survivin supressant: a promising target for cancer therapy and pharmacological profiles of YM155
Kita, Aya, Nakahara, Takahito, Takeuchi, Masahiro, Kinoyama, Isao, Yamanaka, Kentaro, Minematsu, Tsuyoshi, Mitsuoka, Keisuke, Fushiki, Hiroshi, Miyoshi, Sousuke, Sasamata, Masao, Miyata, Keiji
Published in Nihon yakurigaku zasshi (2010)
Published in Nihon yakurigaku zasshi (2010)
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Journal Article
N-Arylpiperazine-1-carboxamide Derivatives
Kinoyama, Isao, Taniguchi, Nobuaki, Kawaminami, Eiji, Nozawa, Eisuke, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru
Published in Chemical & pharmaceutical bulletin (01.04.2005)
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Published in Chemical & pharmaceutical bulletin (01.04.2005)
Journal Article
aneis nitrogenados derivados de acilguanidina
Takuya Washio, Isao Kinoyama, Yohei Koganemaru, Wataru Hamaguchi, Takehiro Miyazaki
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent
derivado de tetrahidroisoquinolina
ISAO KINOYAMA, RYUICHI SEKIOKA, OSAMU KANEKO, TAKEHIRO MIYAZAKI, TAKUYA WASHIO, YOHEI KOGANEMARU, WATARU HAMAGUCHI
Year of Publication 21.03.2017
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Year of Publication 21.03.2017
Patent