P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position
Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Dorsey, Bruce D., McDonough, Colleen M., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Miller-Stein, Cynthia, Michener, Maria T., Wallace, Audrey A., White, Rebecca B., Wong, Bradley K.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Total Synthesis of Baccatin III and Taxol
Danishefsky, Samuel J, Masters, John J, Young, Wendy B, Link, J. T, Snyder, Lawrence B, Magee, Thomas V, Jung, David K, Isaacs, Richard C. A, Bornmann, William G, Alaimo, Cheryl A, Coburn, Craig A, Di Grandi, Martin J
Published in Journal of the American Chemical Society (27.03.1996)
Published in Journal of the American Chemical Society (27.03.1996)
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Journal Article
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors
Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Payne, Linda S., Stauffer, Kenneth J., Williams, Peter D., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., McMasters, Daniel R., Naylor-Olsen, Adel M., Michener, Maria T., Wallace, Audrey A.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles
Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles
Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Journal Article
Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides
Burgey, Christopher S., Robinson, Kyle A., Lyle, Terry A., Nantermet, Philippe G., Selnick, Harold G., Isaacs, Richard C.A., Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, Lyle, Elizabeth A., Stranieri, Maria T., Cook, Jacquelynn J., McMasters, Daniel R., Pellicore, Janetta M., Pal, Swati, Wallace, Audrey A., Clayton, Franklin C., Bohn, Dennis, Welsh, Denise C., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Journal Article
The Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin
Stork, Gilbert, West, Fred, Lee, Hee Yoon, Isaacs, Richard C. A, Manabe, Shino
Published in Journal of the American Chemical Society (30.10.1996)
Published in Journal of the American Chemical Society (30.10.1996)
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Journal Article
C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption
Isaacs, Richard C.A., Cutrona, Kellie J., Newton, Christina L., Sanderson, Philip E.J., Solinsky, Mark G., Baskin, Elizabeth P., Chen, I-Wu, Cooper, Carolyn M., Cook, Jacquelynn J., Gardell, Stephen J., Lewis, S.Dale, Lucas, Robert J., Lyle, Elizabeth A., Lynch, Joseph J., Naylor-Olsen, Adel M., Stranieri, Maria T., Vastag, Kari, Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
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Journal Article
Synthesis of an enantiomerically pure intermediate containing the CD substructure of taxol
Isaacs, Richard C. A, Di Grandi, Martin J, Danishefsky, Samuel J
Published in Journal of organic chemistry (01.07.1993)
Published in Journal of organic chemistry (01.07.1993)
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Journal Article
Degradative routes to electrophilic CD-substructures of taxol
Di Grandi, Martin J, Coburn, Craig A, Isaacs, Richard C. A, Danishefsky, Samuel J
Published in Journal of organic chemistry (01.12.1993)
Published in Journal of organic chemistry (01.12.1993)
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Journal Article
Potassium channel inhibitors
TROTTER, B. WESLEY, WU, ZHICAI, ISAACS, RICHARD C.A, GREEN, AHREN IVER, HOFFMAN, JACOB M, BILODEAU, MARK T
Year of Publication 13.09.2012
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Year of Publication 13.09.2012
Patent
BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS
VENKATRAMAN, SHANKAR, ISAACS, RICHARD C.A, THOMPSON, WAYNE, SU, DAI-SHI, EMBREY, MARK, W, WAI, JOHN, S, LOUGHRAN, H. MARIE, KIM, BOYOUNG, WILLIAMS, PETER, D, LIM, JOHN
Year of Publication 08.08.2012
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Year of Publication 08.08.2012
Patent
HIV INTEGRASE INHIBITORS
FISHER, THORSTEN, E, PAYNE, LINDA S, ISAACS, RICHARD C.A, WAI, JOHN S
Year of Publication 05.08.2009
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Year of Publication 05.08.2009
Patent
BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS
SU DAI-SHI, LIM JOHN, WAI JOHN S, LOUGHRAN H. MARIE, KIM BOYOUNG, WILLIAMS PETER D, VENKATRAMAN SHANKAR, THOMPSON WAYNE, ISAACS RICHARD C.A, EMBREY MARK W
Year of Publication 26.01.2012
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Year of Publication 26.01.2012
Patent