Search Results - "IRENE DRIZIN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

by Jarvis, Michael F, Honore, Prisca, Shieh, Char-Chang, Chapman, Mark, Joshi, Shailen, Zhang, Xu-Feng, Kort, Michael, Carroll, William, Marron, Brian, Atkinson, Robert, Thomas, James, Liu, Dong, Krambis, Michael, Liu, Yi, McGaraughty, Steve, Chu, Katharine, Roeloffs, Rosemarie, Zhong, Chengmin, Mikusa, Joseph P, Hernandez, Gricelda, Gauvin, Donna, Wade, Carrie, Zhu, Chang, Pai, Madhavi, Scanio, Marc, Shi, Lei, Drizin, Irene, Gregg, Robert, Matulenko, Mark, Hakeem, Ahmed, Gross, Michael, Johnson, Matthew, Marsh, Kennan, Wagoner, P. Kay, Sullivan, James P, Faltynek, Connie R, Krafte, Douglas S
Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)

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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

by Drizin, Irene, Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Carroll, William A., Marron, Brian E., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhu, Chang Z., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Roeloffs, Rosemarie, Werness, Stephen, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (15.06.2008)

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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H-4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H-4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

by Cowart, Marlon D., Altenbach, Robert J., Liu, Huaqing, Hsieh, Gin C., Drizin, Irene, Milicic, Ivan, Miller, Thomas R., Witte, David G., Wishart, Neil, Fix-Stenzel, Shannon R., McPherson, Michael J., Adair, Ronald M., Wetter, Jill M., Bettencourt, Brian M., Marsh, Kerman C., Sullivan, James P., Honore, Prisca, Esbenshade, Timothy A., Brioni, Jorge D.
Published in Journal of medicinal chemistry (23.10.2008)

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Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)

Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)

by Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Condon, Stephen, Elmore, Steven W, Kerwin, James F, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Hancock, Arthur A, Brune, Michael E, Buckner, Steven A, Drizin, Irene
Published in Journal of medicinal chemistry (20.04.2000)

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Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Na(v)1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain

Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Na(v)1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain

by Kort, Michael E., Drizin, Irene, Gregg, Robert J., Scanio, Marc J. C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Johnson, Matthew S., Pacofsky, Gregory J., Thomas, James B., Carroll, William A., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C., Murray, Bernard P., Liu, Jinrong, Werness, Stephen, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Chapman, Mark L., Marron, Brian E.
Published in Journal of medicinal chemistry (14.02.2008)

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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

by Cowart, Marlon D, Altenbach, Robert J, Liu, Huaqing, Hsieh, Gin C, Drizin, Irene, Milicic, Ivan, Miller, Thomas R, Witte, David G, Wishart, Neil, Fix-Stenzel, Shannon R, McPherson, Michael J, Adair, Ronald M, Wetter, Jill M, Bettencourt, Brian M, Marsh, Kennan C, Sullivan, James P, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D
Published in Journal of medicinal chemistry (23.10.2008)

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Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

by Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (10.02.2005)

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Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

by Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E
Published in Journal of medicinal chemistry (14.02.2008)

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

by Scanio, Marc J C, Shi, Lei, Drizin, Irene, Gregg, Robert J, Atkinson, Robert N, Thomas, James B, Johnson, Matthew S, Chapman, Mark L, Liu, Dong, Krambis, Michael J, Liu, Yi, Shieh, Char-Chang, Zhang, Xufeng, Simler, Gricelda H, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C, Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S, Jarvis, Michael F, Faltynek, Connie R, Marron, Brian E, Kort, Michael E
Published in Bioorganic & medicinal chemistry (15.11.2010)

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

by SCANIO, Marc J. C, LEI SHI, YI LIU, SHIEH, Char-Chang, XUFENG ZHANG, SIMLER, Gricelda H, JOSHI, Shailen, HONORE, Prisca, MARSH, Kennan C, KNOX, Alison, WERNESS, Stephen, ANTONIO, Brett, DRIZIN, Irene, KRAFTE, Douglas S, JARVIS, Michael F, FALTYNEK, Connie R, MARRON, Brian E, KORT, Michael E, GREGG, Robert J, ATKINSON, Robert N, THOMAS, James B, JOHNSON, Matthew S, CHAPMAN, Mark L, DONG LIU, KRAMBIS, Michael J
Published in Bioorganic & medicinal chemistry (15.11.2010)

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Rigidified 2-aminopyrimidines as histamine H 4 receptor antagonists: Effects of substitution about the rigidifying ring

Rigidified 2-aminopyrimidines as histamine H 4 receptor antagonists: Effects of substitution about the rigidifying ring

by Koenig, John R., Liu, Huaqing, Drizin, Irene, Witte, David G., Carr, Tracy L., Manelli, Arlene M., Milicic, Ivan, Strakhova, Marina I., Miller, Thomas R., Esbenshade, Timothy A., Brioni, Jorge D., Cowart, Marlon
Published in Bioorganic & medicinal chemistry letters (15.03.2010)

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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

by Kort, Michael E, Atkinson, Robert N, Thomas, James B, Drizin, Irene, Johnson, Matthew S, Secrest, Matthew A, Gregg, Robert J, Scanio, Marc J C, Shi, Lei, Hakeem, Ahmed H, Matulenko, Mark A, Chapman, Mark L, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Marron, Brian E
Published in Bioorganic & medicinal chemistry letters (15.11.2010)

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Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring

Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring

by KOENIG, John R, HUAQING LIU, BRIONI, Jorge D, COWART, Marlon, DRIZIN, Irene, WITTE, David G, CARR, Tracy L, MANELLI, Arlene M, MILICIC, Ivan, STRAKHOVA, Marina I, MILLER, Thomas R, ESBENSHADE, Timothy A
Published in Bioorganic & medicinal chemistry letters (15.03.2010)

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α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

by Gomtsyan, Arthur, Bayburt, Erol K., Keddy, Ryan, Turner, Sean C., Jinkerson, Tammie K., Didomenico, Stanley, Perner, Richard J., Koenig, John R., Drizin, Irene, McDonald, Heath A., Surowy, Carol S., Honore, Prisca, Mikusa, Joe, Marsh, Kennan C., Wetter, Jill M., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (15.07.2007)

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Rigidified 2-aminopyrimidines as histamine H sub(4) receptor antagonists: Effects of substitution about the rigidifying ring

Rigidified 2-aminopyrimidines as histamine H sub(4) receptor antagonists: Effects of substitution about the rigidifying ring

by Koenig, John R, Liu, Huaqing, Drizin, Irene, Witte, David G, Carr, Tracy L, Manelli, Arlene M, Milicic, Ivan, Strakhova, Marina I, Miller, Thomas R, Esbenshade, Timothy A, Brioni, Jorge D, Cowart, Marlon
Published in Bioorganic & medicinal chemistry letters (15.03.2010)

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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

by Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Drizin, Irene, Zheng, Guo Zhu, Turner, Sean C, Jinkerson, Tammie, Brown, Brian S, Keddy, Ryan G, Lukin, Kurill, McDonald, Heath A, Honore, Prisca, Mikusa, Joe, Marsh, Kennan C, Wetter, Jill M, St. George, Karen, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (26.07.2007)

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Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as K ATP channel openers (KCOs)

Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as K ATP channel openers (KCOs)

by Drizin, Irene, Holladay, Mark W., Yi, Lin, Zhang, Henry Q., Gopalakrishnan, Sujatha, Gopalakrishnan, Murali, Whiteaker, Kristi L., Buckner, Steven A., Sullivan, James P., Carroll, William A.
Published in Bioorganic & medicinal chemistry letters (03.06.2002)

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Structure-activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)

Structure-activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)

by DRIZIN, Irene, HOLLADAY, Mark W, LIN YI, ZHANG, Henry Q, GOPALAKRISHNAN, Sujatha, GOPALAKRISHNAN, Murali, WHITEAKER, Kristi L, BUCKNER, Steven A, SULLIVAN, James P, CARROLL, William A
Published in Bioorganic & medicinal chemistry letters (03.06.2002)

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na v1.8 sodium channel with efficacy in a model of neuropathic pain

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na v1.8 sodium channel with efficacy in a model of neuropathic pain

by Scanio, Marc J.C., Shi, Lei, Drizin, Irene, Gregg, Robert J., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Liu, Yi, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda H., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Marron, Brian E., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (2010)

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Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K-ATP channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K-ATP opener that selectively inhibits spontaneous bladder contractions

Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K-ATP channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K-ATP opener that selectively inhibits spontaneous bladder contractions

by Carroll, WA, Altenbach, RJ, Bai, H, Brioni, JD, Brune, ME, Buckner, SA, Cassidy, C, Chen, YY, Coghlan, MJ, Daza, AV, Drizin, Fey, TA, Fitzgerald, M, Gopalakrishnan, M, Gregg, RJ, Henry, RF, Holladay, MW, King, LL, Kort, ME, Kym, PR, Milicic, Tang, R, Turner, SC, Whiteaker, KL, Yi, L, Zhang, H, Sullivan, JP
Published in Journal of medicinal chemistry (03.06.2004)

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