Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling
Hosseini, Iraj, Gadkar, Kapil, Stefanich, Eric, Li, Chi-Chung, Sun, Liping L., Chu, Yu-Waye, Ramanujan, Saroja
Published in NPJ systems biology and applications (28.08.2020)
Published in NPJ systems biology and applications (28.08.2020)
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Journal Article
Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL
Susilo, Monica E., Li, Chi‐Chung, Gadkar, Kapil, Hernandez, Genevive, Huw, Ling‐Yuh, Jin, Jin Y., Yin, Shen, Wei, Michael C., Ramanujan, Saroja, Hosseini, Iraj
Published in Clinical and translational science (01.07.2023)
Published in Clinical and translational science (01.07.2023)
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Journal Article
gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application
Hosseini, Iraj, Feigelman, Justin, Gajjala, Anita, Susilo, Monica, Ramakrishnan, Vidya, Ramanujan, Saroja, Gadkar, Kapil
Published in CPT: pharmacometrics and systems pharmacology (01.03.2020)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2020)
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Journal Article
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule
Hosseini, Iraj, Fleisher, Brett, Getz, Jennifer, Decalf, Jérémie, Kwong, Mandy, Ovacik, Meric, Bainbridge, Travis W, Moussion, Christine, Rao, Gautham K, Gadkar, Kapil, Kamath, Amrita V, Ramanujan, Saroja
Published in Pharmaceutics (01.05.2024)
Published in Pharmaceutics (01.05.2024)
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Journal Article
Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy
Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal
Published in Frontiers in pharmacology (03.06.2024)
Published in Frontiers in pharmacology (03.06.2024)
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Journal Article
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities
Shemesh, Colby S., Hsu, Joy C., Hosseini, Iraj, Shen, Ben-Quan, Rotte, Anand, Twomey, Patrick, Girish, Sandhya, Wu, Benjamin
Published in Molecular therapy (03.02.2021)
Published in Molecular therapy (03.02.2021)
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Journal Article
Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics
Lu, Dan, Yadav, Rajbharan, Holder, Patrick, Chiang, Eugene, Sanjabi, Shomyseh, Poon, Victor, Bernett, Matthew, Varma, Rajat, Liu, Ke, Leung, Irene, Bogaert, Liz, Desjarlais, John, Shivva, Vittal, Hosseini, Iraj, Ramanujan, Saroja
Published in European journal of pharmaceutical sciences (01.07.2023)
Published in European journal of pharmaceutical sciences (01.07.2023)
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Journal Article
Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells
Gampa, Gautham, Spinosa, Phillip, Getz, Jennifer, Zhong, Yu, Halpern, Wendy, Esen, Emel, Davies, John, Chou, Cassie, Kwong, Mandy, Wang, Yingyun, Arenzana, Teresita L., Shivva, Vittal, Huseni, Mahrukh, Hsieh, Robert, Schartner, Jill, Koerber, James T., Rutz, Sascha, Hosseini, Iraj
Published in British journal of pharmacology (01.07.2024)
Published in British journal of pharmacology (01.07.2024)
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Journal Article
Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy
Wu, Kai Connie, Adedeji, Adeyemi O., Zabka, Tanja S., Hosseini, Iraj, Kenkre, Radhika, Getz, Jennifer A., Nguyen, Tien, Decalf, Jérémie, Bainbridge, Travis W., Chilton, Jennifer A., Moussion, Christine C., Rao, Gautham K.
Published in Toxicology and applied pharmacology (01.02.2024)
Published in Toxicology and applied pharmacology (01.02.2024)
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Journal Article
DOSING FOR TREATMENT WITH ANTI-CD20/ANTI-CD3 BISPECIFIC ANTIBODIES
LI CHIUNG, KAPIL GADKAR, IRAJ HOSSEINI, SAROJA RAMANUJAN, CHU YU-WAYE
Year of Publication 30.01.2024
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Year of Publication 30.01.2024
Patent
Study of Relationship between Basic Psychological Needs in Relation to Sense of Connectedness with School in Secondary High School Students: The Mediating Effect of Social Self-Efficacy
seyyed jalal hosseini iraj, hossein mahdian, mahmoud Jajarmi
Published in پژوهش در نظامهای آموزشی (01.09.2020)
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Published in پژوهش در نظامهای آموزشی (01.09.2020)
Journal Article
gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development
Hosseini, Iraj, Gajjala, Anita, Bumbaca Yadav, Daniela, Sukumaran, Siddharth, Ramanujan, Saroja, Paxson, Ricardo, Gadkar, Kapil
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2018)
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2018)
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Journal Article
Current practices for QSP model assessment: an IQ consortium survey
Chan, Jason R, Allen, Richard, Boras, Britton, Cabal, Antonio, Damian, Valeriu, Gibbons, Francis D, Gulati, Abhishek, Hosseini, Iraj, Kearns, Jeffrey D, Saito, Ryuta, Cucurull-Sanchez, Lourdes, Selimkhanov, Jangir, Stein, Andrew M, Umehara, Kenichi, Wang, Guanyu, Wang, Weirong, Neves-Zaph, Susana
Published in Journal of pharmacokinetics and pharmacodynamics (11.08.2022)
Published in Journal of pharmacokinetics and pharmacodynamics (11.08.2022)
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Journal Article