Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors
Ni, Yike, Gopalsamy, Ariamala, Cole, Derek, Hu, Yonghan, Denny, Rajiah, Ipek, Manus, Liu, Julie, Lee, Julie, Hall, J. Perry, Luong, Michael, Telliez, Jean-Baptiste, Lin, Lih-Ling
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Get full text
Journal Article
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry (15.12.2005)
Published in Bioorganic & medicinal chemistry (15.12.2005)
Get full text
Journal Article
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes
Wan, Zhao-Kui, Chenail, Eva, Li, Huan-Qiu, Ipek, Manus, Xiang, Jason, Suri, Vipin, Hahm, Seung, Bard, Joel, Svenson, Kristine, Xu, Xin, Tian, Xianbin, Wang, Mengmeng, Li, Xiangping, Johnson, Christian E, Qadri, Ariful, Panza, Darrell, Perreault, Mylene, Mansour, Tarek S, Tobin, James F, Saiah, Eddine
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
Get full text
Journal Article
β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action
Xiang, Jason, Ipek, Manus, Suri, Vipin, Tam, May, Xing, Yuzhe, Huang, Nelson, Zhang, Yanling, Tobin, James, Mansour, Tarek S., McKew, John
Published in Bioorganic & medicinal chemistry (01.07.2007)
Published in Bioorganic & medicinal chemistry (01.07.2007)
Get full text
Journal Article
Indole cytosolic phospholipase A(2) alpha inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
Get full text
Journal Article
Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model
Wan, Zhao-Kui, Chenail, Eva, Xiang, Jason, Li, Huan-Qiu, Ipek, Manus, Bard, Joel, Svenson, Kristine, Mansour, Tarek S, Xu, Xin, Tian, Xianbin, Suri, Vipin, Hahm, Seung, Xing, Yuzhe, Johnson, Christian E, Li, Xiangping, Qadri, Ariful, Panza, Darrell, Perreault, Mylene, Tobin, James F, Saiah, Eddine
Published in Journal of medicinal chemistry (10.09.2009)
Published in Journal of medicinal chemistry (10.09.2009)
Get full text
Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
Get full text
Journal Article
Discovery of indazoles as inhibitors of Tpl2 kinase
Hu, Yonghan, Cole, Derek, Denny, Rajiah Aldrin, Anderson, David R., Ipek, Manus, Ni, Yike, Wang, Xiaolun, Thaisrivongs, Suvit, Chamberlain, Timothy, Hall, J. Perry, Liu, Julie, Luong, Michael, Lin, Lih-Ling, Telliez, Jean-Baptiste, Gopalsamy, Ariamala
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Get full text
Journal Article
Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Xiang, Jason, Ipek, Manus, Suri, Vipin, Massefski, Walt, Pan, Ning, Ge, Ying, Tam, May, Xing, Yuzhe, Tobin, James F., Xu, Xin, Tam, Steve
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Get full text
Journal Article
Piperazine Sulfonamides as Potent, Selective, and Orally Available 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors with Efficacy in the Rat Cortisone-Induced Hyperinsulinemia Model
Xiang, Jason, Wan, Zhao-Kui, Li, Huan-Qiu, Ipek, Manus, Binnun, Eva, Nunez, Jill, Chen, Lihren, McKew, John C, Mansour, Tarek S, Xu, Xin, Suri, Vipin, Tam, May, Xing, Yuzhe, Li, Xiangping, Hahm, Seung, Tobin, James, Saiah, Eddine
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
Get full text
Journal Article
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors
Hopper, Darrin W., Vera, Matthew D., How, David, Sabatini, Joshua, Xiang, Jason S., Ipek, Manus, Thomason, Jennifer, Hu, Yonghan, Feyfant, Eric, Wang, Qin, Georgiadis, Katy E., Reifenberg, Erica, Sheldon, Richard T., Keohan, Cristin C., Majumdar, Manas K., Morris, Elisabeth A., Skotnicki, Jerauld, Sum, Phaik-Eng
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Get full text
Journal Article
Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition
Hu, Yonghan, Xing, Li, Thomason, Jennifer R., Xiang, Jason, Ipek, Manus, Guler, Satenig, Li, Huanqiu, Sabatini, Joshua, Chockalingam, Priya, Reifenberg, Erica, Sheldon, Richard, Morris, Elisabeth A., Georgiadis, Katy E., Tam, Steve
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Get full text
Journal Article
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tp12 kinase inhibitors
NI, Yike, GOPALSAMY, Ariamala, TELLIEZ, Jean-Baptiste, LIN, Lih-Ling, COLE, Derek, YONGHAN HU, DENNY, Rajiah, IPEK, Manus, JULIE LIU, LEE, Julie, PERRY HALL, J, LUONG, Michael
Published in Bioorganic & medicinal chemistry letters (2011)
Get full text
Published in Bioorganic & medicinal chemistry letters (2011)
Journal Article
Discovery of indazoles as inhibitors of Tp12 kinase
YONGHAN HU, COLE, Derek, LIU, Julie, LUONG, Michael, LIN, Lih-Ling, TELLIEZ, Jean-Baptiste, GOPALSAMY, Ariamala, ALDRIN DENNY, Rajiah, ANDERSON, David R, IPEK, Manus, NI, Yike, XIAOLUN WANG, THAISRIVONGS, Suvit, CHAMBERLAIN, Timothy, PERRY HALL, J
Published in Bioorganic & medicinal chemistry letters (2011)
Get full text
Published in Bioorganic & medicinal chemistry letters (2011)
Journal Article
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors
Xiang, Jason S., Hu, Yonghan, Rush, Thomas S., Thomason, Jennifer R., Ipek, Manus, Sum, Phaik-Eng, Abrous, Leila, Sabatini, Joshua J., Georgiadis, Katy, Reifenberg, Erica, Majumdar, Manas, Morris, Elisabeth A., Tam, Steve
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action
Xiang, Jason, Ipek, Manus, Suri, Vipin, Tam, May, Xing, Yuzhe, Huang, Nelson, Zhang, Yanling, Tobin, James, Mansour, Tarek S, McKew, John
Published in Bioorganic & medicinal chemistry (01.07.2007)
Get full text
Published in Bioorganic & medicinal chemistry (01.07.2007)
Journal Article
β-Keto sulfones as inhibitors of 11β-hydroxy steroid dehydrogenase type I and the mechanism of action
XIANG, Jason, IPEK, Manus, SURI, Vipin, TAM, May, YUZHE XING, HUANG, Nelson, YANLING ZHANG, TOBIN, James, MANSOUR, Tarek S, MCKEW, John
Published in Bioorganic & medicinal chemistry (2007)
Get full text
Published in Bioorganic & medicinal chemistry (2007)
Journal Article
Structure-Based Optimization of Protein Tyrosine Phosphatase-1 B Inhibitors: Capturing Interactions with Arginine 24
Wan, Zhao-Kui, Lee, Jinbo, Hotchandani, Rajeev, Moretto, Alessandro, Binnun, Eva, Wilson, Douglas P., Kirincich, Steve J., Follows, Bruce C., Ipek, Manus, Xu, Weixin, Joseph-McCarthy, Diane, Zhang, Yan-Ling, Tam, May, Erbe, David V., Tobin, James F., Li, Wei, Tam, Steve Y., Mansour, Tarek S., Wu, Junjun
Published in ChemMedChem (20.10.2008)
Published in ChemMedChem (20.10.2008)
Get full text
Journal Article
Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1 H -indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (01.06.2008)
Published in Journal of medicinal chemistry (01.06.2008)
Get full text
Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
MCKEW, John C, LEE, Katherine L, CHEN, Lihren, KIRINCICH, Steven J, MICHALAK, Ronald, THOMASON, Jennifer, IPEK, Manus, KUN WU, WOODER, Lane, RAMARAO, Manjunath K, MURPHY, Elizabeth A, GOODWIN, Debra G, SHEN, Marina W. H, ALBERT, Leo, XIN XU, DONAHUE, Frances, SHERRY KU, M, KEITH, James, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, HEGEN, Martin, CLARK, James D, THAKKER, Paresh, FOLEY, Megan A, BEHNKE, Mark L, BAIHUA HU, SUM, Fuk-Wah, TAM, Steve, YONGHAN HU
Published in Journal of medicinal chemistry (2008)
Get full text
Published in Journal of medicinal chemistry (2008)
Journal Article