Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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Experimental and computational study of intermolecular migration of N,N-dimethylcarbamoyl group from N(7) to N(1) on a 7-azaindoline derivative
Uruno, Yoshiharu, Tanaka, Akio, Hashimoto, Kazuki, Usui, Shinya, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Takai, Kentaro, Katoda, Wataru, Fujiwara, Norio, Sumiyoshi, Takaaki
Published in Tetrahedron (18.11.2013)
Published in Tetrahedron (18.11.2013)
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Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M1 and M4 muscarinic acetylcholine receptors agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
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Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury
Inoue, Yasunao, Omodani, Tomoki, Shiratake, Ryotaro, Okazaki, Hiroshi, Kuromiya, Akemi, Kubo, Taeko, Sato, Fuminori
Published in Bioorganic & medicinal chemistry (01.11.2009)
Published in Bioorganic & medicinal chemistry (01.11.2009)
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Journal Article
Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M-1 and M-4 muscarinic acetylcholine receptors selective agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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Stereoselective synthesis of chiral β-amino trifluoromethyl alcohol: development of a manufacturing process for a key intermediate in the production of a novel elastase inhibitor, AE-3763
Inoue, Yasunao, Omodani, Tomoki, Shiratake, Ryotaro, Sato, Fuminori
Published in Tetrahedron: asymmetry (04.08.2010)
Published in Tetrahedron: asymmetry (04.08.2010)
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Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M-1 and M-4 muscarinic acetylcholine receptors agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M sub(1) and M sub(4) muscarinic acetylcholine receptors selective agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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A NEW APPROACH TO THE SYNTHESIS OF OPTICALLY ACTIVE PSEUDO-SUGAR AND PSEUDO-NUCLEOSIDE -SYNTHESES OF PSEUDO-α-D-ARABINOFURANOSE, (+)-CYCLARADINE, AND (+)-1, PSEUDO-β-D-ARABINOFURANOSYLURACIL FROM D-ARABINOSE
YOSHIKAWA, Masayuki, MURAKAMI, Nobutoshi, INOUE, Yasunao, HATAKEYAMA, Shoko, KITAGAWA, Isao
Published in Chemical & pharmaceutical bulletin (1993)
Published in Chemical & pharmaceutical bulletin (1993)
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Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists
Takai, Kentaro, Inoue, Yasunao, Konishi, Yasuko, Suwa, Atsushi, Uruno, Yoshiharu, Matsuda, Harumi, Nakako, Tomokazu, Sakai, Mutsuko, Nishikawa, Hiroyuki, Hashimoto, Gakuji, Enomoto, Takeshi, Kitamura, Atsushi, Uematsu, Yasuaki, Kiyoshi, Akihiko, Sumiyoshi, Takaaki
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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4-ARYLPHENYL DERIVATIVE
KODAMA, TOMOHIRO, FUSANO, AKIRA, IKUMA, YOHEI, HOCHIGAI, HITOSHI, SAWAMURA, KIYOTO, INOUE, YASUNAO, NAKAHIRA, HIROYUKI, FUKUDA, NOBUHISA
Year of Publication 11.06.2009
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Year of Publication 11.06.2009
Patent
MEDICINAL CRYSTALLINE COMPOUND
SATO, FUMINORI, SHIRATAKE, RYOTARO, IMAYOSHI, NORIYUKI, INOUE, YASUNAO
Year of Publication 09.03.2006
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Year of Publication 09.03.2006
Patent
PROCESSES FOR PRODUCING (AMINOMETHYL)TRIFLUOROCARBINOL DERIVATIVES
SATO, FUMINORI, SHIRATAKE, RYOTARO, OMODANI, TOMOKI, INOUE, YASUNAO, DEGUCHI, TAKASHI
Year of Publication 21.06.2001
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Year of Publication 21.06.2001
Patent
Design and Synthesis of Peptide-Based Carboxylic Acid-Containing Transition-State Inhibitors of Human Neutrophil Elastase
Sato, Fuminori, Inoue, Yasunao, Omodani, Tomoki, Imano, Kiyomi, Okazaki, Hiroshi, Takemura, Tadashi, Komiya, Masanobu
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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HETEROCYCLIC COMPOUNDS, INTERMEDIATES THEREOF AND ELASTASE INHIBITORS
HONDA, SEIJI, SATO, FUMINORI, TAKEMURA, TADASHI, SHIRATAKE, RYOTARO, KOMIYA, MASANOBU, OMODANI, TOMOKI, INOUE, YASUNAO
Year of Publication 08.09.2000
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Year of Publication 08.09.2000
Patent