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An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects
Harrell, Andrew W., Wilson, Robert, Man, Yau Lun, Riddell, Kylie, Jarvis, Emily, Young, Graeme, Chambers, Robert, Crossman, Lee, Georgiou, Alex, Pereira, Adrian, Kenworthy, David, Beaumont, Claire, Marotti, Miriam, Wilkes, Denisa, Hessel, Edith M., Fahy, William A.
Published in Drug metabolism and disposition (01.12.2019)
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A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study
Yazici, Y., McAlindon, T.E., Fleischmann, R., Gibofsky, A., Lane, N.E., Kivitz, A.J., Skrepnik, N., Armas, E., Swearingen, C.J., DiFrancesco, A., Tambiah, J.R.S., Hood, J., Hochberg, M.C.
Published in Osteoarthritis and cartilage (01.10.2017)
Published in Osteoarthritis and cartilage (01.10.2017)
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An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia
Sharman, Jeff, Hawkins, Michael, Kolibaba, Kathryn, Boxer, Michael, Klein, Leonard, Wu, Meihua, Hu, Jing, Abella, Steve, Yasenchak, Chris
Published in Blood (09.04.2015)
Published in Blood (09.04.2015)
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Niraparib Population Pharmacokinetics and Exposure-Response Relationships in Patients With Newly Diagnosed Advanced Ovarian Cancer
Monk, Bradley J., Romero, Ignacio, Graybill, Whitney, Churruca, Cristina, O'Malley, David M., Knudsen, Anja Ør, Yap, Oi Wah Stephanie, Baurain, Jean-François, Rose, Peter G., Denys, Hannelore, Ghamande, Sharad, Pisano, Carmela, Fabbro, Michel, Braicu, Elena Ioana, Calvert, Paula M., Amit, Amnon, Prendergast, Emily, Taylor, Adekemi, Kheibarshekan, Leila, Zhang, Zhi-Yi, Zajic, Stefan, Jewell, Roxanne C., Gupta, Divya, González-Martín, Antonio
Published in Clinical therapeutics (01.08.2024)
Published in Clinical therapeutics (01.08.2024)
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Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial
Yazici, Yusuf, McAlindon, Timothy E., Gibofsky, Allan, Lane, Nancy E., Clauw, Daniel, Jones, Morgan, Bergfeld, John, Swearingen, Christopher J., DiFrancesco, Anita, Simsek, Ismail, Tambiah, Jeyanesh, Hochberg, Marc C.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
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Clinical Exploration and Physiologically Based Modelling of the Impact of Hepatic Impairment on Entrectinib Pharmacokinetics
Ozbey, Agustos C, Meneses-Lorente, Georgina, Simmons, Brian, McCallum, Sam, Annaert, Pieter, Parrott, Neil, Umehara, Kenichi
Published in Clinical pharmacokinetics (01.03.2025)
Published in Clinical pharmacokinetics (01.03.2025)
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Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
Holmberg, Ann Aurell, Weidolf, Lars, Necander, Sofia, Bold, Peter, Sidhu, Sharan, Pelay-Gimeno, Marta, de Ligt, Rianne A.F., Verheij, Elwin R., Jauhiainen, Alexandra, Psallidas, Ioannis, Wählby Hamrén, Ulrika, Prothon, Susanne
Published in Drug metabolism and disposition (01.02.2022)
Published in Drug metabolism and disposition (01.02.2022)
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Evaluation of the Safety, Tolerability, and Pharmacokinetics of GSK2269557 (Nemiralisib) Administered Via Dry Powder Inhaler to Healthy Japanese Subjects
Ino, Hiroko, Wilson, Robert, Terao, Takumi, Ogura, Hirofumi, Igarashi, Harue, Cahn, Anthony, Numachi, Yotaro
Published in Clinical pharmacology in drug development (01.01.2019)
Published in Clinical pharmacology in drug development (01.01.2019)
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Pharmacokinetics, Metabolism, and Excretion of [14C]Axitinib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Humans
Smith, Bill J., Pithavala, Yazdi, Bu, Hai-Zhi, Kang, Ping, Hee, Brian, Deese, Alan J., Pool, William F., Klamerus, Karen J., Wu, Ellen Y., Dalvie, Deepak K.
Published in Drug metabolism and disposition (01.05.2014)
Published in Drug metabolism and disposition (01.05.2014)
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INDAZOLES
JONES, PETER, COE, JOTHAM, WADSWORTH, WAKENHUT, FLORIAN, MICHEL, WHITLOCK, GAVIN, ALISTAIR, KORTUM, STEVEN WADE, SABNIS, YOGESH, ANIL, DEHNHARDT, CHRISTOPH, MARTIN
Year of Publication 07.10.2015
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Year of Publication 07.10.2015
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INDAZOLES
JONES, PETER, DEHNHARDT CHRISTOPH MARTIN, COE, JOTHAM, WADSWORTH, WAKENHUT, FLORIAN MICHEL, WHITLOCK, GAVIN, ALISTAIR, KORTUM, STEVEN WADE, SABNIS, YOGESH, ANIL
Year of Publication 19.02.2015
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Year of Publication 19.02.2015
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Clinical Pharmacology of Axitinib
Chen, Ying, Tortorici, Michael A., Garrett, May, Hee, Brian, Klamerus, Karen J., Pithavala, Yazdi K.
Published in Clinical pharmacokinetics (01.09.2013)
Published in Clinical pharmacokinetics (01.09.2013)
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Indazoles
DEHNHARDT CHRISTOPH MARTIN, JONES PETER, WAKENHUT FLORIAN MICHEL, COE JOTHAM WADSWORTH, KORTURN STEVEN WADE, SABNIS YOGESH ANIL, WHITLOCK GAVIN ALISTAIR
Year of Publication 25.11.2014
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Year of Publication 25.11.2014
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An open‐label phase 2 trial of entospletinib in indolent non‐Hodgkin lymphoma and mantle cell lymphoma
Andorsky, David J., Kolibaba, Kathryn S., Assouline, Sarit, Forero‐Torres, Andres, Jones, Vicky, Klein, Leonard M., Patel‐Donnelly, Dipti, Smith, Mitchell, Ye, Wei, Shi, Wen, Yasenchak, Christopher A., Sharman, Jeff P.
Published in British journal of haematology (01.01.2019)
Published in British journal of haematology (01.01.2019)
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INDAZOLES
JONES, PETER, SABNIS, YOGESH ANIL, WAKENHUT, FLORIAN MICHEL, COE, JOTHAM WADSWORTH, KORTUM, STEVEN WADE, DEHNHARDT, CHRISTOPH MARTIN, WHITLOCK, GAVIN ALISTAIR
Year of Publication 30.08.2014
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Year of Publication 30.08.2014
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INDAZOLES
JONES, PETER, COE, JOTHAM, WADSWORTH, WAKENHUT, FLORIAN, MICHEL, WHITLOCK, GAVIN, ALISTAIR, KORTUM, STEVEN WADE, SABNIS, YOGESH, ANIL, DEHNHARDT, CHRISTOPH, MARTIN
Year of Publication 04.06.2014
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Year of Publication 04.06.2014
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INDAZOLES
JONES, PETER, COE, JOTHAM, WADSWORTH, WAKENHUT, FLORIAN, MICHEL, WHITLOCK, GAVIN, ALISTAIR, KORTUM, STEVEN WADE, SABNIS, YOGESH, ANIL, DEHNHARDT, CHRISTOPH, MARTIN
Year of Publication 19.03.2014
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Year of Publication 19.03.2014
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Indazoles
JONES PETER, DEHNHARDT CHRISTOPH, KORTUM STEVEN WADE, SABNIS YOGESH ANIL, WHITLOCK GAVIN ALISTAIR, COE JOTHAM W, WAKENHUT FLORIAN
Year of Publication 10.02.2014
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Year of Publication 10.02.2014
Patent