Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
Kuttruff, Christian A., Fleck, Martin, Carotta, Sebastian, Arnhof, Heribert, Bretschneider, Tom, Dahmann, Georg, Gremel, Gabriela, Grube, Achim, Handschuh, Sandra, Heimann, Annekatrin, Hofmann, Marco H., Impagnatiello, Maria A., Nar, Herbert, Rast, Georg, Schaaf, Otmar, Schmidt, Esther, Oost, Thorsten
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance
Hofmann, Marco H, Mani, Rajeswaran, Engelhardt, Harald, Impagnatiello, Maria A, Carotta, Sebastian, Kerenyi, Marc, Lorenzo-Herrero, Seila, Böttcher, Jark, Scharn, Dirk, Arnhof, Heribert, Zoephel, Andreas, Schnitzer, Renate, Gerstberger, Thomas, Sanderson, Michael P, Rajgolikar, Girish, Goswami, Swagata, Vasu, Sumithira, Ettmayer, Peter, Gonzalez, Segundo, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert, Muthusamy, Natarajan, Moll, Jürgen
Published in Molecular cancer therapeutics (01.04.2020)
Published in Molecular cancer therapeutics (01.04.2020)
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Journal Article
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral
Mei, Miao, Impagnatiello, Maria Antonietta, Jiao, Jun, Reiser, Ulrich, Tontsch-Grunt, Ulrike, Zhang, Ju, Nicklin, Paul, Yu, Bingke, Wang, Yu, He, Yuan, Tan, Xu
Published in Protein & cell (03.01.2024)
Published in Protein & cell (03.01.2024)
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Journal Article
Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells
Impagnatiello, Maria-Antonietta, Weitzer, Stefan, Gannon, Grainne, Compagni, Amelia, Cotten, Matt, Christofori, Gerhard
Published in The Journal of cell biology (05.03.2001)
Published in The Journal of cell biology (05.03.2001)
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Journal Article
Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia
Rudolph, Dorothea, Impagnatiello, Maria Antonietta, Blaukopf, Claudia, Sommer, Christoph, Gerlich, Daniel W, Roth, Mareike, Tontsch-Grunt, Ulrike, Wernitznig, Andreas, Savarese, Fabio, Hofmann, Marco H, Albrecht, Christoph, Geiselmann, Lena, Reschke, Markus, Garin-Chesa, Pilar, Zuber, Johannes, Moll, Jürgen, Adolf, Günther R, Kraut, Norbert
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
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Journal Article
Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics
Pinto, Catarina, Slavic-Obradovic, Ksenija, Fürweger, Daniela, Thaler, Barbara, Souabni, Abdallah, Carotta, Sebastian, Aichinger, Martin, Reiser, Ulrich, Impagnatiello, Maria Antonietta, Tirapu, Iñigo
Published in iScience (21.04.2023)
Published in iScience (21.04.2023)
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Journal Article
Temporal effects of Sprouty on lung morphogenesis
Perl, Anne-Karina T, Hokuto, Isamu, Impagnatiello, Maria-Antonietta, Christofori, Gerhard, Whitsett, Jeffrey A
Published in Developmental biology (01.06.2003)
Published in Developmental biology (01.06.2003)
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Journal Article
Abstract 4450: Therapeutic potential of cargo-armed next generation variants of VSV-GP and synergy with immune modulators
Mueller, Philipp, Nolden, Tobias, Erb, Klaus, Petersson, Monika, Stierstorfer, Brigit, Heinemann, Fabian, Herrmann, Valerie Laura, Impagnatiello, Maria Antonietta, Borges, Eric, Elbers, Knut, Park, John, Wollmann, Guido, Erlmann, Patrik
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
García-Martínez, Juan Manuel, Wang, Shirley, Weishaeupl, Cordula, Wernitznig, Andreas, Chetta, Paolo, Pinto, Catarina, Ho, Jason, Dutcher, Darrin, Gorman, Philip N, Kroe-Barrett, Rachel, Rinnenthal, Joerg, Giragossian, Craig, Impagnatiello, Maria Antonietta, Tirapu, Iñigo, Hilberg, Frank, Kraut, Norbert, Pearson, Mark, Kuenkele, Klaus Peter
Published in Molecular cancer therapeutics (01.01.2021)
Published in Molecular cancer therapeutics (01.01.2021)
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Journal Article
Abstract 2051: BI 905711, a novel CDH17-targeting TRAILR2 agonist, effectively triggers tumor cell apoptosis and tumor regressions selectively in CDH17-positive colorectal cancer models
Garcia-Martinez, Juan Manuel, Wernitznig, Andreas, Rinnenthal, Joerg, Impagnatiello, Maria Antonietta, Hilberg, Frank, Giragossian, Craig, Kraut, Norbert, Pearson, Mark, Kuenkele, Klaus-Peter
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 1951: SMAC mimetic and BET inhibitor - a promising combination for solid cancer treatment
Traexler, Paula-Elena, Arnold, Dominik, Ebner, Florian, Slavic-Obradovic, Ksenija, Jacob, Robin, Thanh, Ha Pham Thi, Aichinger, Martin, Baum, Anke, Wernitznig, Andreas, Gerlach, Daniel, Impagnatiello, Maria-Antonietta, Santoro, Valeria, Olt, Sabine, Scharn, Dirk, Ruzicka, Regina, House, Reniqua P., Murphy, Mary Y., Reiser, Ulrich, Engelhardt, Harald, Zinzalla, Vittoria, Laux, Thorsten, Solca, Flavio, Tontsch-Grunt, Ulrike
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 2267: Therapeutic synergy of the chimeric, oncolytic virus VSV-GP with immune modulators
Mueller, Philipp, Erlmann, Patrik, Petersson, Monika, Nolden, Tobias, Urbiola, Carles, Schreiber, Liesa-Marie, Spiesschaert, Bart, Erb, Klaus, Stierstorfer, Birgit, Impagnatiello, Maria Antonietta, Borges, Eric, Elbers, Knut, Wollmann, Guido, Park, John
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 6221: Targeting IAP in cancer: BI 891065 a potent small molecule SMAC mimetic that synergizes with immune checkpoint inhibition
Aichinger, Martin, Santoro, Valeria, Slavic-Obradovic, Ksenija, Ruhland, Stefanie, Wernitznig, Andreas, Neudolt, Andrea, Schaefer, Markus, Kallenda, Sabine, Zach, Daniel, Olt, Sabine, Salomon, Carina, Rieser, Sarah, Weissenboeck, Martina, Ebner, Florian, Schlattl, Andreas, De Almeida, Melanie Talata, Langlois, Rebecca, Sykora, Martina, Reschke, Markus, Zichner, Thomas, Gerlach, Daniel, Jude, Julian, Fellner, Michaela, Scharn, Dirk, Kraut, Norbert, Moll, Juergen, Zuber, Johannes, Carotta, Sebastian, Impagnatiello, Maria Antonietta, Tontsch-Grunt, Ulrike
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 510: Selective and potent CDK8 inhibitors enhance NK cell activity and promote tumor surveillance
Hofmann, Marco H., Mani, Rajeswaran, Engelhardt, Harald, Impagnatiello, Maria A., Carotta, Sebastian, Kerenyi, Marc A., Lorenzo-Herrero, Seila, Boettcher, Jark, Scharn, Dirk, Arnhof, Heribert, Zoephel, Andreas, Schnitzer, Renate, Gerstberger, Thomas, Rajgolikar, Girish, Goswami, Swagata, Vasu, Sumithira, Ettmayer, Peter, Gonzalez, Segundo R., Pearson, Mark, McConnell, Darryl B., Kraut, Norbert, Muthusamy, Natarajan, Moll, Juergen
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 2330: BI5: a novel SMAC mimetic that triggers tumor cell death and potentiates PD-1 mediated cancer therapy
Reschke, Markus, Impagnatiello, Maria Antonietta, Reiser, Ulrich, Scharn, Dirk, Spevak, Walter, Savchenko, Alexander, Wernitznig, Andreas, Sykora, Martina, Langlois, Rebecca, Zier, Elisabeth, Zach, Daniel, Kallenda, Sabine, Garin-Chesa, Pilar, Quant, Jens, Pearson, Mark, McConnell, Darryl, Kraut, Norbert, Moll, Juergen
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 4630: Development of selective and potent CDK8 inhibitors that increase NK cell activity, which translates in tumor surveillance
Hofmann, Marco H., Engelhardt, Harald, Carotta, Sebastian, Arnhof, Heribert, Scharn, Dirk, Kerenyi, Marc, Mayer, Moritz, Gmaschitz, Gerhard, Egger, Georg, Engelhardt, Christian, Sanderson, Michael, Impagnatiello, Maria A., Schnitzer, Renate, Pearson, Mark, McConnell, Darryl, Kraut, Norbert, Moll, Jürgen
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Efficacy of the Plk Inhibitor Volasertib in Preclinical Models of AML
Rudolph, Dorothea, Albrecht, Christoph, Geiselmann, Lena, Impagnatiello, Maria Antonietta, Garin-Chesa, Pilar, Wernitznig, Andreas, Moll, Jürgen, Kraut, Norbert
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article