The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition
Furet, Pascal, Bordas, Vincent, Le Douget, Mickaël, Salem, Bahaa, Mesrouze, Yannick, Imbach‐Weese, Patricia, Sellner, Holger, Voegtle, Markus, Soldermann, Nicolas, Chapeau, Emilie, Wartmann, Markus, Scheufler, Clemens, Fernandez, Cesar, Kallen, Joerg, Guagnano, Vito, Chène, Patrick, Schmelzle, Tobias
Published in ChemMedChem (06.10.2022)
Published in ChemMedChem (06.10.2022)
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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R.
Published in Nature communications (04.01.2024)
Published in Nature communications (04.01.2024)
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Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R.
Published in Nature communications (19.08.2024)
Published in Nature communications (19.08.2024)
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Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Doriano, Caravatti, Giorgio
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
Martiny-Baron, Georg, Holzer, Philipp, Billy, Eric, Schnell, Christian, Brueggen, Joseph, Ferretti, Mireille, Schmiedeberg, Niko, Wood, Jeanette M., Furet, Pascal, Imbach, Patricia
Published in Angiogenesis (London) (01.09.2010)
Published in Angiogenesis (London) (01.09.2010)
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Journal Article
Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities
Bierer, Donald E, Fort, Diana M, Mendez, Christopher D, Luo, Jian, Imbach, Patricia A, Dubenko, Larisa G, Jolad, Shivanand D, Gerber, R. Eric, Litvak, Joane, Lu, Qing, Zhang, Pingsheng, Reed, Michael J, Waldeck, Nancy, Bruening, Reimar C, Noamesi, Ben K, Hector, Richard F, Carlson, Thomas J, King, Steven R
Published in Journal of medicinal chemistry (12.03.1998)
Published in Journal of medicinal chemistry (12.03.1998)
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Antihyperglycemic Activities of Cryptolepine Analogues: An Ethnobotanical Lead Structure Isolated from Cryptolepis sanguinolenta
Bierer, Donald E, Dubenko, Larisa G, Zhang, Pingsheng, Lu, Qing, Imbach, Patricia A, Garofalo, Albert W, Phuan, Puay-Wah, Fort, Diana M, Litvak, Joane, Gerber, R. Eric, Sloan, Barbara, Luo, Jian, Cooper, Raymond, Reaven, Gerald M
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Non-Covalent Inhibitors of the 20S Proteasome
Carlos García-Echeverría, Patricia Imbach, Johannes Roesel, Peter Fuerst, Marc Lang, Vito Guagnano, Maria Noorani, Johann Zimmermann, Pascal Furet
Published in Chimia (01.04.2003)
Published in Chimia (01.04.2003)
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Journal Article
Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity
Caravatti, Giorgio, Guagnano, Vito, Fairhurst, Robin, Imbach, Patricia, Bruce, Ian, Knapp, Mark, Furet, Pascal, Fritsch, Christine, Pover, Alain De, Blasco, Francesca, Blanz, Joachim, Seiler, Frank H., Fabbro, Doriano, Lang, Marc
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison
Weisberg, Ellen, Roesel, Johannes, Furet, Pascal, Bold, Guido, Imbach, Patricia, Flörsheimer, Andreas, Caravatti, Georgio, Jiang, Jingrui, Manley, Paul, Ray, Arghya, Griffin, James D
Published in Genes & cancer (01.10.2010)
Published in Genes & cancer (01.10.2010)
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Journal Article
Entry into a New Class of Potent Proteasome Inhibitors Having High Antiproliferative Activity by Structure-Based Design
Furet, Pascal, Imbach, Patricia, Noorani, Maria, Koeppler, Juergen, Laumen, Kurt, Lang, Marc, Guagnano, Vito, Fuerst, Peter, Roesel, Johannes, Zimmermann, Johann, García-Echeverría, Carlos
Published in Journal of medicinal chemistry (23.09.2004)
Published in Journal of medicinal chemistry (23.09.2004)
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Novel β-lactam derivatives: Potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome
Imbach, Patricia, Lang, Marc, García-Echeverría, Carlos, Guagnano, Vito, Noorani, Maria, Roesel, Johannes, Bitsch, Francis, Rihs, Grety, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Journal Article
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor
Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field
Vulpetti, Anna, Holzer, Philipp, Schmiedeberg, Niko, Imbach-Weese, Patricia, Pissot-Soldermann, Carole, Hollingworth, Gregory J., Radimerski, Thomas, Thoma, Claudio R., Stachyra, Therese-Marie, Wojtynek, Matthias, Maschlej, Magdalena, Chau, Suzanne, Schuffenhauer, Ansgar, Fernández, César, Schröder, Martin, Renatus, Martin
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)
Furet, Pascal, Bordas, Vincent, Le Douget, Mickaël, Salem, Bahaa, Mesrouze, Yannick, Imbach‐Weese, Patricia, Sellner, Holger, Voegtle, Markus, Soldermann, Nicolas, Chapeau, Emilie, Wartmann, Markus, Scheufler, Clemens, Fernandez, Cesar, Kallen, Joerg, Guagnano, Vito, Chène, Patrick, Schmelzle, Tobias
Published in ChemMedChem (06.10.2022)
Published in ChemMedChem (06.10.2022)
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ORGANIC COMPOUNDS
CARAVATTI GIORGIO, FURET PASCAL, FAIRHURST ROBIN ALEC, GUAGNANO VITO, IMBACH PATRICIA
Year of Publication 14.04.2011
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Year of Publication 14.04.2011
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