A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells
Ishikawa, Yoshinori, Gamo, Kanae, Yabuki, Masato, Takagi, Shinji, Toyoshima, Kosei, Nakayama, Kazuhide, Nakayama, Akiko, Morimoto, Megumi, Miyashita, Hitoshi, Dairiki, Ryo, Hikichi, Yukiko, Tomita, Naoki, Tomita, Daisuke, Imamura, Shinichi, Iwatani, Misa, Kamada, Yusuke, Matsumoto, Satoru, Hara, Ryujiro, Nomura, Toshiyuki, Tsuchida, Ken, Nakamura, Kazuhide
Published in Molecular cancer therapeutics (01.02.2017)
Published in Molecular cancer therapeutics (01.02.2017)
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Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase
Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Ono, Koji, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Morishita, Daisuke, Kitazawa, Satoshi, Uchiyama, Noriko, Ogawa, Kazumasa, Kimura, Hiromichi, Imamura, Shinichi
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
Sakai, Takayuki, Ogata, Aya, Ikenuma, Hiroshi, Yamada, Takashi, Hattori, Saori, Abe, Junichiro, Imamura, Shinichi, Ichise, Masanori, Tada, Mari, Kakita, Akiyoshi, Koyama, Hiroko, Suzuki, Masaaki, Kato, Takashi, Ito, Kengo, Kimura, Yasuyuki
Published in EJNMMI radiopharmacy and chemistry (04.03.2024)
Published in EJNMMI radiopharmacy and chemistry (04.03.2024)
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Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
Miyamoto, Naoki, Oguro, Yuya, Takagi, Terufumi, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.12.2012)
Published in Bioorganic & medicinal chemistry (15.12.2012)
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Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of vascular endothelial growth factor and platelet‐derived growth factor receptor tyrosine kinase
Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Tsuchiya, Shuntarou, Nakamura, Kazuhide, Kakoi, Yuichi, Kitahara, Osamu, Takeuchi, Toshiyuki, Yamasaki, Seiji, Miyamoto, Naoki, Iwata, Hidehisa, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Published in Cancer science (01.04.2013)
Published in Cancer science (01.04.2013)
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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic
Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis
Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Iwata, Hidehisa, Oguro, Yuya, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Published in Cancer science (01.05.2012)
Published in Cancer science (01.05.2012)
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Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives
Imamura, Shinichi, Ishihara, Yuji, Hattori, Taeko, Kurasawa, Osamu, Matsushita, Yoshihiro, Sugihara, Yoshihiro, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Hashiguchi, Shohei
Published in Chemical & Pharmaceutical Bulletin (2004)
Published in Chemical & Pharmaceutical Bulletin (2004)
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CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N′-diphenylureas
Imamura, Shinichi, Kurasawa, Osamu, Nara, Yoshi, Ichikawa, Takashi, Nishikawa, Youichi, Iida, Takehiro, Hashiguchi, Shohei, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Sugihara, Yoshihiro
Published in Bioorganic & medicinal chemistry (01.05.2004)
Published in Bioorganic & medicinal chemistry (01.05.2004)
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Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo-[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation
OGURO, Yuya, MIYAMOTO, Naoki, OKADA, Kengo, TAKAGI, Terufumi, IWATA, Hidehisa, AWAZU, Yoshiko, MIKI, Hiroshi, HORI, Akira, KAMIYAMA, Keiji, IMAMURA, Shinichi
Published in Bioorganic & medicinal chemistry (15.10.2010)
Published in Bioorganic & medicinal chemistry (15.10.2010)
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Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors
Matsumoto, Shigemitsu, Miyamoto, Naoki, Hirayama, Takaharu, Oki, Hideyuki, Okada, Kengo, Tawada, Michiko, Iwata, Hidehisa, Nakamura, Kazuhide, Yamasaki, Seiji, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents
Kojima, Takuto, Asano, Yasutomi, Kurasawa, Osamu, Hirata, Yasuhiro, Iwamura, Naoki, Wong, Tzu-Tshin, Saito, Bunnai, Tanaka, Yuta, Arai, Ryosuke, Yonemori, Kazuko, Miyamoto, Yasufumi, Sagiya, Yoji, Yaguchi, Masahiro, Shibata, Sachio, Mizutani, Akio, Sano, Osamu, Adachi, Ryutaro, Satomi, Yoshinori, Hirayama, Megumi, Aoyama, Kazunobu, Hiura, Yuto, Kiba, Atsushi, Kitamura, Shuji, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.04.2013)
Published in Bioorganic & medicinal chemistry (15.04.2013)
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A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities
Awazu, Yoshiko, Nakamura, Kazuhide, Mizutani, Akio, Kakoi, Yuichi, Iwata, Hidehisa, Yamasaki, Seiji, Miyamoto, Naoki, Imamura, Shinichi, Miki, Hiroshi, Hori, Akira
Published in Molecular cancer therapeutics (01.06.2013)
Published in Molecular cancer therapeutics (01.06.2013)
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Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics
Oguro, Yuya, Cary, Douglas R., Miyamoto, Naoki, Tawada, Michiko, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.08.2013)
Published in Bioorganic & medicinal chemistry (01.08.2013)
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HETEROCYCLIC COMPOUND
IMAMURA SHINICHI, OSAKO MAMI, KOSEKI KOICHI, KAMETAKA AI, KAWAI AKIYOSHI, TAKAHASHI KOICHI
Year of Publication 07.10.2022
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Year of Publication 07.10.2022
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