Search Results - "IMAMURA, SHINICHI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

by Ishikawa, Yoshinori, Gamo, Kanae, Yabuki, Masato, Takagi, Shinji, Toyoshima, Kosei, Nakayama, Kazuhide, Nakayama, Akiko, Morimoto, Megumi, Miyashita, Hitoshi, Dairiki, Ryo, Hikichi, Yukiko, Tomita, Naoki, Tomita, Daisuke, Imamura, Shinichi, Iwatani, Misa, Kamada, Yusuke, Matsumoto, Satoru, Hara, Ryujiro, Nomura, Toshiyuki, Tsuchida, Ken, Nakamura, Kazuhide
Published in Molecular cancer therapeutics (01.02.2017)

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Journal Article

Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase

Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase

by Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Ono, Koji, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Morishita, Daisuke, Kitazawa, Satoshi, Uchiyama, Noriko, Ogawa, Kazumasa, Kimura, Hiromichi, Imamura, Shinichi
Published in Journal of medicinal chemistry (26.03.2020)

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A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain

A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain

by Sakai, Takayuki, Ogata, Aya, Ikenuma, Hiroshi, Yamada, Takashi, Hattori, Saori, Abe, Junichiro, Imamura, Shinichi, Ichise, Masanori, Tada, Mari, Kakita, Akiyoshi, Koyama, Hiroko, Suzuki, Masaaki, Kato, Takashi, Ito, Kengo, Kimura, Yasuyuki
Published in EJNMMI radiopharmacy and chemistry (04.03.2024)

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Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors

Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors

by Miyamoto, Naoki, Oguro, Yuya, Takagi, Terufumi, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.12.2012)

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Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of vascular endothelial growth factor and platelet‐derived growth factor receptor tyrosine kinase

Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of vascular endothelial growth factor and platelet‐derived growth factor receptor tyrosine kinase

by Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Tsuchiya, Shuntarou, Nakamura, Kazuhide, Kakoi, Yuichi, Kitahara, Osamu, Takeuchi, Toshiyuki, Yamasaki, Seiji, Miyamoto, Naoki, Iwata, Hidehisa, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Published in Cancer science (01.04.2013)

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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic

Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic

by Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (14.02.2013)

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A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis

A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis

by Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Iwata, Hidehisa, Oguro, Yuya, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Published in Cancer science (01.05.2012)

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Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

by Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.04.2013)

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Journal Article

ROOM CONSTRUCTION PANEL

ROOM CONSTRUCTION PANEL

by SUZUKI EIJI, IMAMURA SHINICHI
Year of Publication 07.03.2024

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Patent

CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives

CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives

by Imamura, Shinichi, Ishihara, Yuji, Hattori, Taeko, Kurasawa, Osamu, Matsushita, Yoshihiro, Sugihara, Yoshihiro, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Hashiguchi, Shohei
Published in Chemical & Pharmaceutical Bulletin (2004)

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Journal Article

CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N′-diphenylureas

CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N′-diphenylureas

by Imamura, Shinichi, Kurasawa, Osamu, Nara, Yoshi, Ichikawa, Takashi, Nishikawa, Youichi, Iida, Takehiro, Hashiguchi, Shohei, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Sugihara, Yoshihiro
Published in Bioorganic & medicinal chemistry (01.05.2004)

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Journal Article

INCOMING CALL MANAGEMENT SYSTEM

INCOMING CALL MANAGEMENT SYSTEM

by IMAMURA SHINICHI
Year of Publication 09.05.2016

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Patent

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo-[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo-[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

by OGURO, Yuya, MIYAMOTO, Naoki, OKADA, Kengo, TAKAGI, Terufumi, IWATA, Hidehisa, AWAZU, Yoshiko, MIKI, Hiroshi, HORI, Akira, KAMIYAMA, Keiji, IMAMURA, Shinichi
Published in Bioorganic & medicinal chemistry (15.10.2010)

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Journal Article

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

by Matsumoto, Shigemitsu, Miyamoto, Naoki, Hirayama, Takaharu, Oki, Hideyuki, Okada, Kengo, Tawada, Michiko, Iwata, Hidehisa, Nakamura, Kazuhide, Yamasaki, Seiji, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.12.2013)

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Journal Article

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

by Kojima, Takuto, Asano, Yasutomi, Kurasawa, Osamu, Hirata, Yasuhiro, Iwamura, Naoki, Wong, Tzu-Tshin, Saito, Bunnai, Tanaka, Yuta, Arai, Ryosuke, Yonemori, Kazuko, Miyamoto, Yasufumi, Sagiya, Yoji, Yaguchi, Masahiro, Shibata, Sachio, Mizutani, Akio, Sano, Osamu, Adachi, Ryutaro, Satomi, Yoshinori, Hirayama, Megumi, Aoyama, Kazunobu, Hiura, Yuto, Kiba, Atsushi, Kitamura, Shuji, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.05.2018)

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Journal Article

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

by Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.04.2013)

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Journal Article

Biochemical Characterization of TAK-593, a Novel VEGFR/PDGFR Inhibitor with a Two-Step Slow Binding Mechanism

Biochemical Characterization of TAK-593, a Novel VEGFR/PDGFR Inhibitor with a Two-Step Slow Binding Mechanism

by Iwata, Hidehisa, Imamura, Shinichi, Hori, Akira, Hixon, Mark S, Kimura, Hiroyuki, Miki, Hiroshi
Published in Biochemistry (Easton) (08.02.2011)

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Journal Article

A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities

A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities

by Awazu, Yoshiko, Nakamura, Kazuhide, Mizutani, Akio, Kakoi, Yuichi, Iwata, Hidehisa, Yamasaki, Seiji, Miyamoto, Naoki, Imamura, Shinichi, Miki, Hiroshi, Hori, Akira
Published in Molecular cancer therapeutics (01.06.2013)

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Journal Article

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics

by Oguro, Yuya, Cary, Douglas R., Miyamoto, Naoki, Tawada, Michiko, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.08.2013)

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Journal Article

HETEROCYCLIC COMPOUND

HETEROCYCLIC COMPOUND

by IMAMURA SHINICHI, OSAKO MAMI, KOSEKI KOICHI, KAMETAKA AI, KAWAI AKIYOSHI, TAKAHASHI KOICHI
Year of Publication 07.10.2022

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Patent

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